Viroplasm and large virus-like particles in the dinoflagellate Gymnodinium uberrimum

Virus-like particles (VLPs) measuring 385±5 nm in diameter are described in the freshwater dinoflagellate Gymnodinium uberrimum . The VLPs are found in association with, and “budding” from a vesicular viroplasmic area. A similar viroplasm was also found in a chrysophycean alga, Mallomonas sp. collected from the same general area in Saginaw Bay of Lake Huron. The nature of these VLPs and their virogenic stroma, in these algae from the Laurentian Great Lakes are discussed in the present report.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/41733/1/709_2005_Article_BF01275735.pd

The contribution of X-linked coding variation to severe developmental disorders

Abstract: Over 130 X-linked genes have been robustly associated with developmental disorders, and X-linked causes have been hypothesised to underlie the higher developmental disorder rates in males. Here, we evaluate the burden of X-linked coding variation in 11,044 developmental disorder patients, and find a similar rate of X-linked causes in males and females (6.0% and 6.9%, respectively), indicating that such variants do not account for the 1.4-fold male bias. We develop an improved strategy to detect X-linked developmental disorders and identify 23 significant genes, all of which were previously known, consistent with our inference that the vast majority of the X-linked burden is in known developmental disorder-associated genes. Importantly, we estimate that, in male probands, only 13% of inherited rare missense variants in known developmental disorder-associated genes are likely to be pathogenic. Our results demonstrate that statistical analysis of large datasets can refine our understanding of modes of inheritance for individual X-linked disorders

Is the Interleukin 8 Promoter Polymorphism rs4073/-251T >A Associated With Clostridium difficile Infection?

The interleukin 8 gene single-nucleotide polymorphism rs4073/–251T >A predisposes to Clostridium difficile infection (CDI), but this association has not been independently validated. In this study, we were unable to replicate this association in either a white cohort or by meta-analysis, suggesting that rs4073/–251T >A is unlikely to constitute a major risk factor for CDI