Cosmic ray particle detectors designed for interplanetary studies utilizing the Pioneers 8, 9, and 10 spacecrafts Final report

Design and performance of cosmic ray detector packages for Pioneer space probe

Low-energy particle events associated with sector boundaries

Onsets of some 40 to 45 low-energy proton events during the years 1957–1969 coincided in time with transits of well-defined sector boundaries across the Earth. These events can be interpreted as long-lived proton streams filling up some of the magnetic sectors, indicating an acceleration of protons which is not associated with typical proton-producing flares. The sharp onsets of these particle streams, as well as a deficiency of flare-associated particle events shortly before the boundary transit, indicate that in some cases magnetic sector boundaries can inhibit transverse propagation of low-energy particles in the solar corona or in interplanetary space.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/43744/1/11207_2004_Article_BF00155310.pd

The Structure of Ethnic Networks and Exports: Evidence from Germany

This paper provides evidence of the effect of immigration-based networks on German trade. Germany presents a particular interesting case study to examine the effect of ethnic networks on exports due to its high export dependence and its reserved migration policy. According to our results, we find no trade creating effect from migrant networks on exports but on imports, highlighting the importance of the demand effect for Germany. Allowing for heterogeneous network effects shows that at least some migrant networks positively affect exports. However, the most efficient migrant networks do not originate from EU countries but from African or middle-eastern countries that do not have a large migrant network in Germany

Histoplasma capsulatum Heat-Shock 60 Orchestrates the Adaptation of the Fungus to Temperature Stress

Heat shock proteins (Hsps) are among the most widely distributed and evolutionary conserved proteins. Hsps are essential regulators of diverse constitutive metabolic processes and are markedly upregulated during stress. A 62 kDa Hsp (Hsp60) of Histoplasma capsulatum (Hc) is an immunodominant antigen and the major surface ligand to CR3 receptors on macrophages. However little is known about the function of this protein within the fungus. We characterized Hc Hsp60-protein interactions under different temperature to gain insights of its additional functions oncell wall dynamism, heat stress and pathogenesis. We conducted co-immunoprecipitations with antibodies to Hc Hsp60 using cytoplasmic and cell wall extracts. Interacting proteins were identified by shotgun proteomics. For the cell wall, 84 common interactions were identified among the 3 growth conditions, including proteins involved in heat-shock response, sugar and amino acid/protein metabolism and cell signaling. Unique interactions were found at each temperature [30°C (81 proteins), 37°C (14) and 37/40°C (47)]. There were fewer unique interactions in cytoplasm [30°C (6), 37°C (25) and 37/40°C (39)] and four common interactions, including additional Hsps and other known virulence factors. These results show the complexity of Hsp60 function and provide insights into Hc biology, which may lead to new avenues for the management of histoplasmosis