PECULIARITIES OF THE KRASNODAR REGION’S TEENAGERS’ NEUROLOGICAL STATUS

The aim of this scientific work is detecting of neurological pathology among first grade students. We examined 2507 students (1414 male and 1093 female) in the age from 16 to 18 in the process of deep medical examination. We collected neurological complains, neurostatus, analyses of medical documentation. This data was statistically handled. Therefore 80% of students had neurological pathology. The most frequent cases were vegetative-vascular dystonia, vertebrogenic pathology and essential headache. The gained data means the very high level of neurological disease among students, which shows not only importance of rehabilitation activities, but modernization of preventive activities among adolescences

PREDICTIVE CAPABILITY OF NEUROTRACTOGRAPHY IN PREMATURE NEWBORNS WITH LOW AND EXTREMELY LOW BODY WEIGHT WITH MANIFESTING BRONCHOPULMONARY DYSPLASIA

Aim. The purpose of the work is the study of the impact of bronchopulmonary dysplasia on the prognosis of perinatal brain injury in premature newborns with low and extremely low body weight considering the results of neurotractography.Materials and methods. 61 children born with low and extremely low body weight took part in our study. The first group included 22 newborns with manifesting bronchopulmonary dysplasia; the second group included 39 newborns without bronchopulmonary dysplasia. Perinatal brain injury of hypoxic-ischemic genesis of moderate severity was diagnosed in all cases.Results. Significant differences in groups during the antenatal and intrapartum periods were not detected. Period of respiratory support was significantly different in groups. Damage оf corticospinal tract was not detected by MRI.Conclusion. Rehabilitation of newborns without bronchopulmonary dysplasia was faster in the first months

PHYSICAL DEVELOPMENT DISORDERS OF CHILDREN WITH DIFFERENT OUTCOMES OF PERINATAL BRAIN LESIONS

The article presents data on the physical development disorders of children with different outcomes of perinatal brain lesions. The children, gone through neonatal reanimation, have different outcomes during postnatal development, they are: neurological deficit – 43,7 %, minimum cerebral dysfunctions (functional disorders) – 56,3 %. Physical development disorders were found in 58,2 % of children with neurological deficit and in 39,4 % of children with minimum cerebral dysfunctions (р<0, 05). The prevalence of underweight children was determined in children with neurological deficit (р<0, 001), and the prevalence of excess weight gain was noted in children with minimum cerebral dysfunctions (р<0, 05). Analysis of physical development was carried with using of the sigma deviations method. Analysis of psychomotor development was carried with using the Clinical Adaptive Test/Clinical Linguistic and Auditory Milestone Scale

THE VALUE OF MAGNETIC RESONANCE IMAGING FOR EARLY DIAGNOSTICS OF PERINATAL HYPOXIC-ISCHEMIC BRAIN LESIONS

The article presents advantages of usе the diffusion-weighted magnetic resonance imaging (DW MRI) for revealing of hypoxic-ischemic brain lesions in neonates. The trial included 105 neonates with perinatal brain lesions who had been undergoing treatment at a resuscitation department or neonatel pathology department in the first month of life. The article shows high information value of diffusion-weighted imagings (DWI) for diagnostics of hypoxic-ischemic lesions. In the event of no structural brain lesions of neonates, pronounced increase in signal characteristics revealed by DWI indicated considerable pathophysiological alterations. Subsequently, children developed structural alterations in the form of cystic encephalomalacia with the expansion of cerebrospinal fluid spaces manifested with pronounced neurological deficit

CLINICOPATHOLOGIC CRITERIA OF PERINATAL BRAIN INJURY IN CHILDREN BORN WITH LOW AND EXTREMELY LOW BODY WEIGHT

Aim. The objective of this study was to establish structural changes in the brain of preterm neonates born with low and extremely low body weight, with perinatal brain damage of moderate severity by neurotractography. Materials and methods. 48 children born with very low and extremely low body weight were examined. Structural changes according to neurosonography were revealed in all. Neurotractography was performed before discharge from the nursing department.Results. A significant difference in the neurological status before discharge was not detected in children. The area of interest was the crus posterius capsulae internae during neurotractography. Reduction of FA and increase of ADC was detected in three cases. These children had a motormental retardation at the adjusted age of 12 months.Conclusions. Neuropathography results can increase the accuracy of later neurologic prognosis. If significant changes in the neurotractography are not recorded, then a favorable neurological prognosis is predicte

THE PREVALENCE OF VEGETATIVE DYSFUNCTION AMONG TEENAGERS IN THE KRASNODAR REGION

Aim. The objective of this study was detecting of neurological pathology among first grade students.Materials and methods. We examined 2507 students (1414 male and 1093 female) in the age from 16 to18 in the process of deep medical examination. We collected neurological complains, neurostatus, analyses of medical documentation. This data was statistically handled.Results. Therefore 80% of students had neurological pathology. The most frequent cases were vegetative-vascular dystonia, vertebrogenic pathology and essential headache.Conclusions. The gained data means the very high level of neurological disease among students, which shows not only importance of rehabilitation activities, but modernization of preventive activities among adolescences

PREVALENCE OF PHYSICAL DEVELOPMENT OF PUPILS OF THE KRASNODAR TERRITORY

Students surveyed in 1927 Krasnodar territory aged 7–17 years. It is shown that a body mass index of the Krasnodar territory students mostly average – 43,6%. Percentile ranks are designed to assess the physical development of children 7–17 years for growth, weight and BMI adjusted for age and sex. A comparison of the studied parameters with physical development, WHO 2007. In general, children with high rates prevail over children with low height and weight. Body weight above 95 centile was noted in 11,2%, less than 5 centile – 2,8% of the school, which is 4 times less. Tall (over 95 centile) – 7,1% versus 2,7% growth – less than 5 centile

CHARACTERISTICS OF CYSTIC FIBROSIS IN THE KRASNODAR REGION ACCORDING TO A EUROPEAN REGISTER FOR 2011

Creation of the Russian register of patients with cystic fibrosis and participation in the program European register is essential for patients in the region and in the country. Result of creating and analyzing annual data register should be the understanding of the following fundamental epidemiological indicators: number of patients, including deaths, number, patient age, their sex distribution. Analysis of the register of patients showed that the proportion of children and adolescents dominates adults (58 children and 14 adults), the average age of the patients below the other regions of the country and the world. Clinical-laboratory features of cystic fibrosis in the Krasnodar region showed an increase in complications of the disease and Pseudomonas aeruginosa infection with age. Total number of mutations have been identified 7, which was 75%. Results register landmark adoption of adequate institutional, medical and social measures when working with patients suffering from cystic fibrosis

EFFICIENCY OF COMPLEX THERAPY OF PREMATURE WITH SURGICAL PATHOLOGY

Aim. Estimate the efficiency of improved complex therapy of premature with surgical pathology.Materials and methods. 374 medical histories of premature infants were studied. The number of medical histories for 2011 was 169, and the number of medical histories for 2016 was 205.Results. There is an increase in the number of premature with surgical pathology. The number of premature infants increased with a gestation period of less than 28 weeks and decreased among children with a gestation period of 32-34 weeks. The percentage of deceased children with a gestation period of 32-37 weeks has significantly decreased. Decrease in lethality of premature with surgical pathology in 2 times.Conclusion. Results of this study confirmed effectiveness of the improvement of complex therapy of premature with surgical pathology

IMMUNOTHERAPY OF GASTRIC ULCER DISEASE, ASSOCIATED WITH HELIСOBACTER PYLORI USING RECOMBINANT IL-2

Aim. To determine the clinical, morphological and microbiological efficacy of treatment of gastric ulcer associated with Helicobacter pylori, using recombinant interleukin-2 "Roncoleukin" without antibiotics.Materials and methods. 108 patients suffering from HP-associated gastric ulcer disease were randomly divided into two groups. The I group of patients was cured with standard three or four component methods of therapy included proton pomp inhibitors and two antibiotics (usually Klaritromycin and Amoxicillin). Patients of the second group were treated with the same therapy, but instead of antibiotics they received 0,1 mg rIL-2 – Roncoleukin into four – six points submucously using gastroscope techniques and 0,4 mg was dissolved in 400 ml 0,9% NaCl and infused intravenously. This procedure was performed three times with the interval of 72 hours.Results. One month after the end of treatment it was found that in the group treated with rIL-2 the HP eradication achieved in 95,4% in comparison to 81,5% in control patients. In Roncoleukin treated group ulcer epithelization period was 10,79±0,46 days and in traditionally treated group – 35,23±1,58 days. In third month of monitoring in gastric mucosae bioptates of basic group patients in 93,5% there were no morphological inflammatory signs and in 81,4% of patients intestinal metaplasia disappiered. Conclusion. The proposed method of complex treatment of gastric ulcer associated with Helicobacter pylori is clinically and pathogenetically justified