Screening properties and phase transitions in unconventional plasmas for Ising-type quantum Hall states

Utilizing large-scale Monte-Carlo simulations, we investigate an unconventional two-component classical plasma in two dimensions which controls the behavior of the norms and overlaps of the quantum-mechanical wavefunctions of Ising-type quantum Hall states. The plasma differs fundamentally from that which is associated with the two-dimensional XY model and Abelian fractional quantum Hall states. We find that this unconventional plasma undergoes a Berezinskii-Kosterlitz-Thouless phase transition from an insulator to a metal. The parameter values corresponding to Ising-type quantum Hall states lie on the metallic side of this transition. This result verifies the required properties of the unconventional plasma used to demonstrate that Ising-type quantum Hall states possess quasiparticles with non-Abelian braiding statistics.Comment: 16 pages, 14 figures. Submitted to Physical Review

The phases of deuterium at extreme densities

We consider deuterium compressed to higher than atomic, but lower than nuclear densities. At such densities deuterium is a superconducting quantum liquid. Generically, two superconducting phases compete, a "ferromagnetic" and a "nematic" one. We provide a power counting argument suggesting that the dominant interactions in the deuteron liquid are perturbative (but screened) Coulomb interactions. At very high densities the ground state is determined by very small nuclear interaction effects that probably favor the ferromagnetic phase. At lower densities the symmetry of the theory is effectively enhanced to SU(3), and the quantum liquid enters a novel phase, neither ferromagnetic nor nematic. Our results can serve as a starting point for investigations of the phase dynamics of deuteron liquids, as well as exploration of the stability and dynamics of the rich variety of topological objects that may occur in phases of the deuteron quantum liquid, which range from Alice strings to spin skyrmions to Z_2 vortices.Comment: 9 pages, 6 figures; v2: fixed typo

The health economic impact of disease management programs for COPD: A systematic literature review and meta-analysis

__Abstract__ Background: There is insufficient evidence of the cost-effectiveness of Chronic Obstructive Pulmonary Disease (COPD) Disease Management (COPD-DM) programs. The aim of this review is to evaluate the economic impact of COPD-DM programs and investigate the relation between the impact on healthcare costs and health outcomes. We also investigated the impact of patient-, intervention, and study-characteristics.Methods: We conducted a systematic literature review to identify cost-effectiveness studies of COPD-DM. Where feasible, results were pooled using random-effects meta-analysis and explorative subgroup analyses were performed.Results: Sixteen papers describing 11 studies were included (7 randomized control trials (RCT), 2 pre-post, 2 case-control). Meta-analysis showed that COPD-DM led to hospitalization savings of €1060 (95% CI: €2040 to €80) per patient per year and savings in total healthcare uti

Type-1.5 superconductivity in multicomponent systems

In general a superconducting state breaks multiple symmetries and, therefore, is characterized by several different coherence lengths $\xi_i$, $i=1,...,N$. Moreover in multiband material even superconducting states that break only a single symmetry are nonetheless described, under certain conditions by multi-component theories with multiple coherence lengths. As a result of that there can appear a state where some coherence lengths are larger and some are smaller than the magnetic field penetration length $\lambda$: $\xi_1\leq \xi_2... < \sqrt{2}\lambda<\xi_M\leq...\xi_N$. That state was recently termed "type-1.5" superconductivity. This breakdown of type-1/type-2 dichotomy is rather generic near a phase transition between superconducting states with different symmetries. The examples include the transitions between $U(1)$ and $U(1)\times U(1)$ states or between $U(1)$ and $U(1)\times Z_2$ states. The later example is realized in systems that feature transition between s-wave and $s+is$ states. The extra fundamental length scales have many physical consequences. In particular in these regimes vortices can attract one another at long range but repel at shorter ranges. Such a system can form vortex clusters in low magnetic fields. The vortex clustering in the type-1.5 regime gives rise to many physical effects, ranging from macroscopic phase separation in domains of different broken symmetries, to unusual transport properties

Reassessing the Evidence Hierarchy in Asthma: Evaluating Comparative Effectiveness

Classical randomized controlled trials are the gold standard in medical evidence because of their high internal validity. However, their necessarily strict design can limit their external validity and the ability to extrapolate these data to real world patients. Therefore, alternatively designed studies may play a complementary role in evaluating the comparative effectiveness of therapies in nonidealized patients in more naturalistic, real world settings. Observational studies have high external validity and can evaluate real world outcomes. Their strength lies in hypothesis generation and testing and in identifying areas in which further clinical trials may be required. Pragmatic trials are designed to maximize applicability of trial results to usual care settings by relying on clinically important outcomes and enrolling a wide range of participants. A combination of these approaches is preferable and necessary