2 research outputs found
Atomic Force Microscopy of height fluctuations of fibroblast cells
We investigated the nanometer scale height fluctuations of 3T3 fibroblast
cells with the atomic force microscope (AFM) under physiological conditions.
Correlation between these fluctuations and lateral cellular motility can be
observed. Fluctuations measured on leading edges appear to be predominantly
related to actin polymerization-depolymerization processes. We found fast (5
Hz) pulsatory behavior with 1--2 nm amplitude on a cell with low motility
showing emphasized structure of stress fibres. Myosin driven contractions of
stress fibres are thought to induce this pulsation.Comment: 6 pages, 5 figures, 1 tabl