Engagement Differences for 2-year-olds Identified as Late Talker

The investigators compared engagement in language-rich activities for 2-year-olds identified as late talkers and their typically developing peers. Participants included twelve 2-year-old children ranging in age from 24- to 33-months of age (M = 27 months; SD= 2.906), three were identified as being typically developing, five were identified as having expressive-only language delay, and four were identified as having expressive and receptive language delay. From videotaped interactions, child behaviors were coded as unengaged (e.g., uninvolved with any specific people, objects, or symbols), onlooking (e.g., watching researcher or parent activity, but not taking part), person engaged (e.g., involved solely with researcher/parent as social partners), or object engaged (e.g., playing with objects such as toys and/or picture symbols alone) for 15-second increments of all videotaped interactions (M = 378.13 minutes per participant; SD = 11.89). Consistent with previous findings for typically developing and expressive-only late talkers, no significant engagement differences were noted across participant groupings; however, a nonsignificant trend was notable for object-engagement with expressive-receptive late talkers

Non-statistically populated autoionizing levels of Li-like carbon: Hidden-crossings

The intensities of the Auger-electron lines from autoionizing (AI) states of Li-like (1s2s2l) configurations excited in ion-atom collisions vary as functions of the collision parameters such as, for example, the collision velocity. A statistical population of the three-electron levels is at best incomplete and underscores the intricate dynamical development of the electronic states. The authors compare several experimental studies to calculations using ``hidden-crossing`` techniques to explore some of the details of these Auger-electron intensity variation phenomena. The investigations show promising results suggesting that Auger-electron intensity variations can be used to probe collision dynamics

Search for exchange-antisymmetric two-photon states

Atomic two-photon J=0 $\leftrightarrow$J'=1 transitions are forbidden for photons of the same energy. This selection rule is related to the fact that photons obey Bose-Einstein statistics. We have searched for small violations of this selection rule by studying transitions in atomic Ba. We set a limit on the probability $v$ that photons are in exchange-antisymmetric states: $v<1.2\cdot10^{-7}$.Comment: 5 pages, 4 figures, ReVTeX and .eps. Submitted to Phys. Rev. Lett. Revised version 9/25/9

Newly established tumourigenic primary human colon cancer cell lines are sensitive to TRAIL-induced apoptosis in vitro and in vivo

Most data on the therapeutic potential of tumour necrosis factor-related apoptosis-inducing ligand (TRAIL) as well as resistance to FAS ligand (FASL) in colorectal cancer have come from in vitro studies using cell lines. To gain a clearer understanding about the susceptibility of patient tumours to TRAIL and FASL, we derived primary human cancer epithelial cells from colon cancer patients. Characterisation of primary cultures PAP60 and MIH55 determined their highly proliferating advantage, transforming capability and tumorigenicity in vitro and in vivo. Although FASL treatment appeared to cause little apoptosis only in the PAP60 primary culture, increased apoptosis independent of p53 was observed in both primary PAP60 and MIH55 and control cell lines Caco-2, HT29 and DLD-1 after treatment with SuperKiller TRAIL. Expression analysis of death receptors (DR) in the original parental tumours, the primary cultures before and after engraftment as well as the mouse xenografts, revealed a significant upregulation of both DR4 and DR5, which correlated to differences in sensitivity of the cells to TRAIL-induced apoptosis. Treating patient tumour xenograft/SCID mouse models with Killer TRAIL in vivo suppressed tumour growth. This is the first demonstration of TRAIL-induced apoptosis in characterised tumorigenic primary human cultures (in vitro) and antitumour activity in xenograft models (in vivo)

Worth the ‘EEfRT’? The Effort Expenditure for Rewards Task as an Objective Measure of Motivation and Anhedonia

Background: Of the putative psychopathological endophenotypes in major depressive disorder (MDD), the anhedonic subtype is particularly well supported. Anhedonia is generally assumed to reflect aberrant motivation and reward responsivity. However, research has been limited by a lack of objective measures of reward motivation. We present the Effort-Expenditure for Rewards Task (EEfRT or ‘‘effort’’), a novel behavioral paradigm as a means of exploring effort-based decision-making in humans. Using the EEfRT, we test the hypothesis that effort-based decision-making is related to trait anhedonia. Methods/Results: 61 undergraduate students participated in the experiment. Subjects completed self-report measures of mood and trait anhedonia, and completed the EEfRT. Across multiple analyses, we found a significant inverse relationship between anhedonia and willingness to expend effort for rewards. Conclusions: These findings suggest that anhedonia is specifically associated with decreased motivation for rewards, and provide initial validation for the EEfRT as a laboratory-based behavioral measure of reward motivation and effort-base