33,697 research outputs found
CMB Constraint on Radion Evolution in the Brane World Scenario
In many versions of brane model, the modulus field of extra dimensions, the
radion, could have cosmological evolution, which induces variation of the Higgs
vacuum expectation value, , resulting in cosmological variation of the
electron mass $m_e$. The formation of Cosmic Microwave Background (CMB)
anisotropies is thus affected, causing changes both in the peaks positions and
amplitudes in the CMB power spectra. Using the three-year Wilkinson Microwave
Anisotropies Probe (WMAP) CMB data, with the Hubble parameter $H_0$ fixed to be
the Hubble Space Telescope (HST) result 72 km s$^{-1}$ Mpc$^{-1}$, we obtain a
constraint on $\rho$, the ratio of the value of at CMB recombination to
its present value, to be [0.97, 1.02].Comment: 7 pages, 6 figures, minor changes of format to conform with PRD
forma
Cosmic ray feedback in the FIRE simulations: constraining cosmic ray propagation with GeV gamma ray emission
We present the implementation and the first results of cosmic ray (CR)
feedback in the Feedback In Realistic Environments (FIRE) simulations. We
investigate CR feedback in non-cosmological simulations of dwarf, sub-
starburst, and galaxies with different propagation models, including
advection, isotropic and anisotropic diffusion, and streaming along field lines
with different transport coefficients. We simulate CR diffusion and streaming
simultaneously in galaxies with high resolution, using a two moment method. We
forward-model and compare to observations of -ray emission from nearby
and starburst galaxies. We reproduce the -ray observations of dwarf and
galaxies with constant isotropic diffusion coefficient . Advection-only and streaming-only
models produce order-of-magnitude too large -ray luminosities in dwarf
and galaxies. We show that in models that match the -ray
observations, most CRs escape low-gas-density galaxies (e.g.\ dwarfs) before
significant collisional losses, while starburst galaxies are CR proton
calorimeters. While adiabatic losses can be significant, they occur only after
CRs escape galaxies, so they are only of secondary importance for -ray
emissivities. Models where CRs are ``trapped'' in the star-forming disk have
lower star formation efficiency, but these models are ruled out by -ray
observations. For models with constant that match the -ray
observations, CRs form extended halos with scale heights of several kpc to
several tens of kpc.Comment: 31 pages, 26 figures, accepted for publication in MNRA
Halo Sampling, Local Bias and Loop Corrections
We develop a new test of local bias, by constructing a locally biased halo
density field from sampling the dark matter-halo distribution. Our test differs
from conventional tests in that it preserves the full scatter in the bias
relation and it does not rely on perturbation theory. We put forward that bias
parameters obtained using a smoothing scale R can only be applied to computing
the halo power spectrum at scales k ~ 1/R. Our calculations can automatically
include the running of bias parameters and give vanishingly small loop
corrections at low-k. Our proposal results in much better agreement of the
sampling and perturbation theory results with simulations. In particular,
unlike the standard interpretation of local bias in the literature, our
treatment of local bias does not generate a constant power in the low-k limit.
We search for extra noise in the Poisson corrected halo power spectrum at
wavenumbers below its turn-over and find no evidence of significant positive
noise (as predicted by the standard interpretation) while we find evidence of
negative noise coming from halo exclusion for very massive halos. Using
perturbation theory and our non-perturbative sampling technique we also
demonstrate that nonlocal bias effects discovered recently in simulations
impact the power spectrum only at the few percent level in the weakly nonlinear
regime.Comment: 25 pages, 14 figures; V2: significant revision including more details
about halo exclusion and low-k noise. Conclusions unchange
A staged approach with vincristine, adriamycin, and dexamethasone followed by bortezomib, thalidomide, and dexamethasone before autologous hematopoietic stem cell transplantation in the treatment of newly diagnosed multiple myeloma
Bortezomib-based regimens have significant activities in multiple myeloma (MM). In this study, we tested the efficacy of a total therapy with a staged approach where newly diagnosed MM patients received vincristine/adriamycin/dexamethsone (VAD). VAD-sensitive patients (≥75% paraprotein reduction) received autologous hematopoietic stem cell transplantation (auto-HSCT), whereas less VAD-sensitive patients (<75% paraprotein reduction) received bortezomib/thalidomide/dexamethasone (VTD) for further cytoreduction prior to auto-HSCT. On an intention-to-treat analysis, a progressive increase of complete remission (CR) rates was observed, with cumulative CR rates of 48% after HSCT. Seven patients progressed leading to three fatalities, of which two had central nervous system disease. The 3-year overall survival and event-free survival were 75.1% and 48.3%, respectively. Six patients developed oligoclonal reconstitution with new paraproteins. In the absence of anticoagulant prophylaxis, no patients developed deep vein thrombosis. The staged application of VAD+/–VTD/auto-HSCT resulted in an appreciable response rate and promising survivals. Our approach reduced the use of bortezomib without compromising the ultimate CR rate and is of financial significance for less affluent communities
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