What’s Driving Food Prices in 2011?

Agricultural Finance, Demand and Price Analysis, Food Consumption/Nutrition/Food Safety,

Extended Molecular Gas in the Nearby Starburst Galaxy Maffei 2

We present a 9'x9' fully-sampled map of the CO J=1-0 emission in the nearby starburst galaxy Maffei 2 obtained at the Five College Radio Astronomy Observatory. The map reveals previously known strong CO emission in the central starburst region as well as an extended asymmetric distribution with bright CO lines at the ends of the bar and in a feature at the north-east edge of the molecular disk. This northern feature, proposed previously to be an interacting companion galaxy, could be a dwarf irregular galaxy, although the CO data are also consistent with the feature being simply an extension of one of the spiral arms. We estimate the total molecular gas mass of Maffei 2 to be (1.4-1.7)x10^9 Mo or ~3-4% of its dynamical mass. Adopting the recently determined lower value for the CO-to-H2 conversion factor in the central region, our data lead to the surprising result that the largest concentrations of molecular gas in Maffei 2 lie at the bar ends and in the putative dwarf companion rather than in the central starburst. A gravitational stability analysis reveals that the extended disk of Maffei 2 lies above the critical density for star formation; however, whether the central region is also gravitationally unstable depends both on the details of the rotation curve and the precise value of the CO-to-H2 conversion factor in this region.Comment: accepted to ApJ (Sept 10 2004 issue

Research in the general area of non-linear dynamical systems Final report, 8 Jun. 1965 - 8 Jun. 1967

Nonlinear dynamical systems research on systems stability, invariance principles, Liapunov functions, and Volterra and functional integral equation

Enzymatic hydrolysate from velvet antler suppresses adipogenesis in 3T3-L1 cells and attenuates obesity in high-fat diet-fed mice

The purpose of the current study was to investigate the potential anti-obesity activity of an enzymatic hydrolysate of velvet antler in inhibiting adipogenesis in 3T3-L1 cells and in high-fat diet (HFD)-fed obese mice. The enzy- matic hydrolysate was prepared using the commercial food grade protease, Protamex. The velvet antler Protamex hydrolysate (VAPH) indicated profound inhibitory effects on adipogenesis dose-dependently by decreasing the accumulation of triglycerides and down-regulating expression levels of adipogenesis-related proteins C/EBPα, SREBP-1, and PPARγ. In a mouse model of HFD-induced obesity, oral administration of VAPH (100 and 300 mg/kg for 13 weeks) significantly reduced the body weight gain that had resulted from the HFD. VAPH treat- ment also lowered the serum glucose and triglyceride levels, while increasing the HDL-C level. Furthermore, the treatment greatly reduced hepatic lipid droplet accumulation as well as the size of adipocytes. Current findings H has profound anti-obesity effects and could be an effective candidate for preventing obesity and obesity-related chronic diseases

Biogenesis of mitochondrial porin

We review here the present knowledge about the pathway of import and assembly of porin into mitochondria and compare it to those of other mitochondrial proteins. Porin, like all outer mitochondrial membrane proteins studied so far is made as a precursor without a cleavble lsquosignalrsquo sequence; thus targeting information must reside in the mature sequence. At least part of this information appears to be located at the amino-terminal end of the molecule. Transport into mitochondria can occur post-translationally. In a first step, the porin precursor is specifically recognized on the mitochondrial surface by a protease sensitive receptor. In a second step, porin precursor inserts partially into the outer membrane. This step is mediated by a component of the import machinery common to the import pathways of precursor proteins destined for other mitochondrial subcompartments. Finally, porin is assembled to produce the functional oligomeric form of an integral membrane protein wich is characterized by its extreme protease resistance

Long-term results and recurrence patterns from SCALOP: a phase II randomised trial of gemcitabine- or capecitabine-based chemoradiation for locally advanced pancreatic cancer

background: SCALOP, a randomised, phase II trial, tested the activity and safety of gemcitabine (GEM)-based and capecitabine (CAP)-based chemoradiation (CRT) for locally advanced pancreatic cancer (LAPC). Here we present the long-term outcomes. methods: Eligibility: histologically proven LAPC less than or equal to7 cm. Following 12 weeks of induction GEMCAP chemotherapy (three cycles: GEM 1000 mg m−2 days 1, 8, 15; CAP 830 mg m−2 days 1–21 q28 days) patients with stable/responding disease, tumour less than or equal to6 cm, and WHO Performance Status 0–1 were randomised to receive one cycle GEMCAP followed by CAP (830 mg m−2 b.d. on weekdays only) or GEM (300 mg m−2 weekly) with radiation (50.4 Gy per 28 fractions). results: One-hundred fourteen patients (28 UK centres) were registered between 24 December 2009 and 25 October 2011, and 74 were randomised (CAP-RT=36; GEM-RT=38). At the time of this analysis, 105 of the 114 patients had died and the surviving 9 patients had been followed up for a median of 10.9 months (IQR: 2.9–18.7). Updated median OS was 17.6 months (95% CI: 14.6–22.7) in the CAP-CRT arm and 14.6 months (95% CI: 11.1–16.0) in the GEM-CRT arm (intention-to-treat adjusted hazard ratio (HR): 0.68 (95% CI: 0.38–1.21, P=0.185)); median progression-free survival (PFS) was 12.0 months (95% CI: 10.0–15.2) in the CAP-CRT arm and 10.4 months (95% CI: 8.8–12.7) in the GEM-CRT arm (intention-to-treat adjusted HR: 0.60 (95% CI: 0.32–1.14, P=0.120)). In baseline multivariable model, age greater than or equal to65 years, better performance status, CA19.9<613 IU l−1, and shorter tumour diameter predicted improved OS. CAP-CRT, age greater than or equal to65 years, better performance status, CA19.9 <46 IU ml−1 predicted improved OS and PFS in the pre-radiotherapy model. Nine-month PFS was highly predictive of OS. conclusions: CAP-CRT remains the superior regimen. SCALOP showed that patients with CA19.9 <46 IU ml−1 after induction chemotherapy are more likely to benefit from CRT

Nuclear Bar Catalyzed Star Formation: 13^CO, C18^O and Molecular Gas Properties in the Nucleus of Maffei 2

(Abridged) We present resolution maps of CO, its isotopologues, and HCN from in the center of Maffei 2. The J=1-0 rotational lines of 12^CO, 13^CO, C18^O and HCN, and the J=2-1 lines of 13^CO and C18^O were observed with the OVRO and BIMA arrays. The 2-1/1-0 line ratios of the isotopologues constrain the bulk of the molecular gas to originate in low excitation, subthermal gas. From LVG modeling, we infer that the central GMCs have n(H_2) ~10^2.75 cm^-3 and T_k ~ 30 K. Continuum emission at 3.4 mm, 2.7 mm and 1.4 mm was mapped to determine the distribution and amount of HII regions and dust. Column densities derived from C18^O and 1.4 mm dust continuum fluxes indicate the CO conversion factor in the center of Maffei 2 is lower than Galactic by factors of ~2-4. Gas morphology and the clear ``parallelogram'' in the Position-Velocity diagram shows that molecular gas orbits within the potential of a nuclear (~220 pc) bar. The nuclear bar is distinct from the bar that governs the large scale morphology of Maffei 2. Giant molecular clouds in the nucleus are nonspherical and have large linewidths. Dense gas and star formation are concentrated at the sites of the x_1-x_2 orbit intersections of the nuclear bar, suggesting that the starburst is dynamically triggered.Comment: 50 pages, 14 figures, accepted for publication in Ap

Characteristics of a Widespread Community Cluster of H275Y Oseltamivir-Resistant A(H1N1)pdm09 Influenza in Australia

Background. Oseltamivir resistance in A(H1N1)pdm09 influenza is rare, particularly in untreated community cases. Sustained community transmission has not previously been reported

Development of a Weldable Neutron Absorbing Structural Material

The National Spent Nuclear Fuel Program, located at the Idaho National Laboratory, coordinates and integrates national efforts in management and disposal of U.S. Department of Energy (DOE)-owned spent nuclear fuel. These management functions include development of standardized systems for packaging, storage, treatment, transport, and long-term disposal in the proposed Yucca Mountain Repository. Nuclear criticality control measures are needed in these systems to avoid restrictive fissile loading limits because of the enrichment and total quantity of fissile material in some types of the DOE spent nuclear fuel. This paper will outline the results to date of a metallurgical development program that is investigating the alloying of gadolinium into a nickel-chromium-molybdenum alloy matrix. Gadolinium has been chosen as the neutron absorption alloying element due to its high thermal neutron absorption cross section and low solubility in the expected repository environment. The nickel-chromium-molybdenum alloy family was chosen for its known corrosion performance, mechanical properties, and weldability. The workflow of this program includes chemical composition definition, primary melting and secondary refining studies, ingot conversion process evaluations, mechanical/physical properties and corrosion testing, welding studies, and national consensus codes, and standards work

Influenza Outbreaks during World Youth Day 2008 Mass Gathering

Novel viruses were introduced and seasonal viruses were amplified