Dynamic Mechanical Behavior of Black Cherry (Prunus Serotina EHRH.)

The dynamic mechanical properties of black cherry (Prunus serotina Ehrh.) have been investigated as a function of temperature at audio frequencies. Relaxation processes are evident near 200, 360, and 510 K. The process near 200 K was investigated as a function of initial moisture content (based on mass measurements prior to testing). At moisture contents greater than about 20%, the damping peak is centered near 185 K. This relaxation shifts with moisture content, and at moisture contents below 6%, the peak is centered near 225 K. The relaxation in the 360 K region is also associated with initial moisture content. For oven-dry black cherry specimens, the dynamic mechanical properties in the 360 K region are nearly temperature-independent. The relaxation near 510 K is believed to be associated with thermal degradation of wood constituents that are known to degrade in that temperature region

Comparison Of Red Maple (Acer Rubrum L.) And Aspen (Populus Grandidentata Michx) 3-Layered Flakeboards

Three-layered flakeboards were fabricated using long and short flakes of red maple (Acer rubrum L.) and aspen (Populus grandidentata Michx). Panels were fabricated using three layers of a single species or face layers of a single species with a core layer of the other species. Static bending, internal bond, and nail withdrawal values indicated that red maple and aspen boards for the most part were comparable. A mixed species board with aspen in the face layers and red maple in the core layer had some of the highest static bending values. Dimensional stability values were acceptable among all boards with the mixed species boards producing some of the lowest values. Red maple 3-layered flakeboards were similar to aspen 3-layered boards and it appeared that red maple and aspen may be mixed to produce quality 3-layered flakeboards

Impregnation of Wood With a High Viscosity Epoxy Resin

A method is described for impregnating small wood specimens with a high viscosity epoxy resin, without the use of a diluent to reduce viscosity. The method relies upon the strong temperature-dependence of viscosity, in conjunction with a curing agent that does not polymerize rapidly at high temperatures. Some preliminary results for a variety of Northeastern species are presented

Dynamic Mechanical Properties of Epoxy-Poplar Composite Materials

The effects of impregnation on the dynamic mechanical properties of yellow-poplar (Liriodendron tulipifera L.) sapwood have been investigated for stoichiometric and nonstoichiometric mixtures of a diglycidyl ether of bisphenol-A based epoxy resin and meta-phenylenediamine. For the temperature range from 0 to 100 C, the measured values for the dynamic modulus of these wood-polymer composites exceeded the predicted values based upon the rule of mixtures. In contrast, the actual results for the internal friction values were significantly lower than those predicted by the rule of mixtures. Modification of this equation for strain energy sharing effects resulted in much improved estimates for the internal friction values, however

A Note on the Flexural Properties of Bark Board

Bending properties of particleboards made from soft maple, red oak, white oak, black cherry, beech, and yellow-poplar bark were obtained and compared with the specimen's density and thickness. Regression analyses indicated that the bending properties depend not only on species but also on density and/or specimen thickness. This dependence was not consistent among species

Some Physical Properties of Birch Carbonized in A Nitrogen Atmosphere

The dynamic mechanical properties, mass loss, and shrinkage data of birch carbonized in a nitrogen atmosphere to different temperatures from 473 to 973 K have been investigated. The dynamic elastic modulus data decreased as the heat treatment temperatures approached 673 K. Major mass loss and shrinkage accompanied the decrease in the modulus data. Treatments at higher temperatures (> 673 K) produced substantially less additional mass loss and shrinkage but produced increased rigidity in the char. The internal friction behavior of the char was complex

Effect of Epoxy Impregnation on the Moe and Mor of Intact and Failed Yellow-Poplar (Liriodendron Tulipifera L.) Sapwood Beams

The effects of epoxy impregnation on the MOR and MOE of intact and failed yellow-poplar (Liriodendron tulipifera L.) clear sapwood beams were investigated. Both impregnated and unimpregnated specimens were partially failed in bending, impregnated to stabilize the cracks, and retested. The presence of induced cracks had a significant effect on the MOR of the material after impregnation or reimpregnation, but not on the MOE. Both the MOR and MOE of the failed, then impregnated material exceeded the values for unimpregnated yellow-poplar

The Effect of Species and Substrate Density on the Flexural Properties of Epoxy-Impregnated Barkboard

Bark from red oak, yellow-poplar, soft maple, and beech was individually mixed with 6% (by weight) powdered phenolic resin and pressed into boards having nominal densities of 40, 50, 60, and 70 lb/ft3 (0.64, 0.80, 0.96, and 1.12 g/cm3). Half of these boards were used as controls and half were impregnated with a solution of 100 parts by weight of epoxy resin, 25 parts styrene oxide, and 12.06 parts N,N-diethyl-1, 3-propanediamine. Polymer retention was found to be linearly related to the substrate density and was somewhat dependent upon the species of bark. The impregnation process resulted in dramatic changes in the flexural properties of the barkboard. Increases in MOR of 3.0- to 4.0-fold and in MOE of 2.6- and 3.6-fold were observed over control values, with the largest improvements occurring in the red oak specimens. In contrast to the control specimens, MOR and MOE values for the epoxy-impregnated specimens were not well correlated. In addition, correlations of MOR with the substrate density and polymer mass loading were generally low or varied greatly with bark species. MOE correlations were notably higher, but variable

Carotid intimal-media thickness as a surrogate for cardiovascular disease events in trials of HMG-CoA reductase inhibitors

BACKGROUND: Surrogate measures for cardiovascular disease events have the potential to increase greatly the efficiency of clinical trials. A leading candidate for such a surrogate is the progression of intima-media thickness (IMT) of the carotid artery; much experience has been gained with this endpoint in trials of HMG-CoA reductase inhibitors (statins). METHODS AND RESULTS: We examine two separate systems of criteria that have been proposed to define surrogate endpoints, based on clinical and statistical arguments. We use published results and a formal meta-analysis to evaluate whether progression of carotid IMT meets these criteria for HMG-CoA reductase inhibitors (statins). IMT meets clinical-based criteria to serve as a surrogate endpoint for cardiovascular events in statin trials, based on relative efficiency, linkage to endpoints, and congruency of effects. Results from a meta-analysis and post-trial follow-up from a single published study suggest that IMT meets established statistical criteria by accounting for intervention effects in regression models. CONCLUSION: Carotid IMT progression meets accepted definitions of a surrogate for cardiovascular disease endpoints in statin trials. This does not, however, establish that it may serve universally as a surrogate marker in trials of other agents

Genetic dissection reveals diabetes loci proximal to the gimap5 lymphopenia gene

rats are protected from type 1 diabetes (T1D) by 34 Mb of F344 DNA introgressed proximal to the gimap5 lymphopenia gene. To dissect the genetic factor(s) that confer protection from T1D in the DRF. f/f rat line, DRF. f/f rats were crossed to inbred BBDR or DR. lyp/lyp rats to generate congenic sublines that were genotyped and monitored for T1D, and positional candidate genes were sequenced. All (100%) DR. f/f congenic sublines further refined the RNO4 region 1 interval to ϳ670 kb and region 2 to the 340 kb proximal to gimap5. All congenic DRF. f/f sublines were prone to low-grade pancreatic mononuclear cell infiltration around ducts and vessels, but Ͻ20% of islets in nondiabetic rats showed islet infiltration. Coding sequence analysis revealed TCR V␤ 8E, 12, and 13 as candidate genes in region 1 and znf467 and atp6v0e2 as candidate genes in region 2. Our results show that spontaneous T1D is controlled by at least two genetic loci 7 Mb apart on rat chromosome 4. type 1 diabetes; BB rat; T cell receptor; autoimmune CHARACTERISTICS OF TYPE 1 DIABETES (T1D) in both human and the BioBreeding spontaneously diabetes-prone (BBDP) rat include polyuria, hyperglycemia, ketoacidosis, insulitis, and insulin dependency for life. As in human T1D, islets are infiltrated by mononuclear cells at the time of onset with rapid hyperglycemia due to a complete loss of islet ␤-cells (32). The genetic etiology of human T1D remains complex and although the major histocompatibility complex (MHC) (HLA DQ) on chromosome 6 accounts for ϳ40% of T1D risk, the number of non-HLA genetic factors is increasing steadily (2, 7). The BB rat offers a powerful model to dissect both genetic contributions and mechanisms by which immunemediated beta cell killing induces T1D (3, 4, 15, 17-21, 27, 28, 46). As in humans, the major genetic determinant of susceptibility in the BB rat is the MHC (Iddm1) on rat chromosome (RNO) 20. The class II MHC locus RT1B/D. u/u ), an ortholog of human HLA DQ (9), is necessary but not sufficient for T1D in the BBDP rat and other RT1. u/u -related rat strains with spontaneous (24, 47) or induced T1D (8, 43). In BBDP, a null mutation in the gimap5 gene (lyp; Iddm2) on RNO4 (14, 27) causes lymphopenia and is tightly linked to spontaneous T1D development. The DR. lyp/lyp rat with 2 Mb of BBDP DNA encompassing gimap5 introgressed into the genome of related BBDR rats (BioBreeding resistant to spontaneous T1D) are also 100% lymphopenic and 100% spontaneously diabetic (11). With complete T1D penetrance and tight regulation of onset, the congenic DR. lyp/lyp rat line offers distinct advantages in identification of genes responsible for disease progression. It is possible to induce T1D in BBDR rats (32) and related RT1 u/u rats (8) by administration of polyinosinic: polycytidylic acid (poly I:C, an activator of innate immunity), the T reg depleting cytotoxic DS4.23 anti-ART2.1 (formerly RT6) monoclonal antibody or by viral infection (34). This indicates that the BBDR has an underlying genetic susceptibility to T1D. In crosses between WF and either BBDP or BBDR rats, a quantitative trait locus (QTL) important for induced T1D (Iddm14, previously designated Iddm4) was mapped to RNO4 (6, Interestingly, F344 DNA introgressed between D4Rat253 and D4Rhw6 into the congenic DR. lyp/lyp genetic background resulted in a lymphopenic but nondiabetic rat (designated DRF. f/f ) (11). Protection from T1D in the DRF. f/f congenic rat line led us to conclude that spontaneous T1D in the BB rat is controlled, in part, by a diabetogenic factor(s) independent of the gimap5 mutation (76.84 Mb) on RNO4. This congenic interval is encompassed within Iddm14, raising the possibility that the Iddm14 locus could be required for both spontaneous and induced T1D in the BB rat. The aim of this study was to cross the DRF. f/f rat to BBDR and DR. lyp/lyp rats and produce recombinant sublines that could be assessed for both lymphopenia and diabetes and to estimate the number of independent genes on RNO4 that control spontaneous T1D