Proton beam radiotherapy in the management of uveal melanoma: clinical experience in Scotland

<p>Aim: To evaluate proton-beam radiotherapy (PBRT) in the management of uveal melanoma in Scotland.</p> <p>Methods: A retrospective review was undertaken on all patients receiving PBRT for uveal melanoma (1994–2005). Data obtained included: gender, past ocular/medical history, age, presenting complaint(s), diagnosis, laterality, tumor location/ultrasound characteristics, visual acuity (VA) and intraocular pressure. At post-treatment reviews (3, 6, 12, and 24 months), the following data was obtained: VA, intraocular pressure, tumor appearance and ultrasound characteristics. Mean follow up was 38.8 months.</p> <p>Results: Seventy-six patients were included. Mean age was 64 years; male to female ratio was 1.1:1. Ninety-seven percent demonstrated initial treatment response; 87% had successful control of tumor growth. Mean pre-treatment tumor height was 6.2 mm v.s. 4.8 mm post-irradiation (p < 0.001). Pre-irradiation VA was <3/60 in 18.5% compared with 74% post-irradiation (p < 0.0001). There was a statistically significant association between adverse events (enucleation, metastasis) and greater maximal basal tumor diameter. Eighteen eyes were enucleated. The median survival time was estimated to be 54 months.</p> <p>Conclusion: In our experience, PBRT is a precise, reliable and effective treatment in the management of large, and previously treated uveal melanomas. It prevents enucleation in the majority at short term follow-up.</p&gt

’Eyes free’ in-car assistance: parent and child passenger collaboration during phone calls

This paper examines routine family car journeys, looking specifically at how passengers assist during a mobile telephone call while the drivers address the competing demands of handling the vehicle, interacting with various artefacts and controls in the cabin, and engage in co-located and remote conversations while navigating through busy city roads. Based on an analysis of video fragments, we see how drivers and child passengers form their conversations and requests around the call so as to be meaningful and paced to the demands, knowledge and abilities of their cooccupants, and how the conditions of the road and emergent traffic are oriented to and negotiated in the context of the social interaction that they exist alongside. The study provides implications for the design of car-based collaborative media and considers how hands- and eyesfree natural interfaces could be tailored to the complexity of activities in the car and on the road