Comparative analysis of hemodynamic characteristics of the biological xenogenic pericardial prosthesis MEDINGE-BIO with “easy change” system and the xenogenic aortic prosthesis Hancock II after aortic valve replacement

Aim. To compare the outcomes of aortic valve replacement using the xenogenic aortic prosthesis Hancock II and the novel Russian xenogenic pericardial prosthesis MEDINGE-BIO.Material and methods. The study included patients operated on for aortic stenosis in the cardiac surgery department № 1 of the Cardiology Research Institute (Tomsk National Research Medical Center). All patients were divided into two groups. The first group included 54 patients with Hancock II prostheses, the second — 91 patients with MEDINGE-BIO prostheses. Hemodynamic characteristics of heart valves were assessed by echocardiography before surgery and before discharge (on average 10 days after surgery).Results. When comparing hemodynamic parameters before and after surgery, significant differences between the groups were not obtained. The average pressure gradient after surgery using Hancock II and MEDINGE-BIO prosthesis was 21,6±7,9 and 17,9±5,6 mm Hg, respectively (p=0,05).Conclusion. The comparative analysis showed that the novel biological prosthesis MEDINGE-BIO has comparable hemodynamic characteristics with the well-known aortic prosthesis Hancock II

Influence of implantation of a novel domestic prosthetic aortic valve on the functional class of heart failure one year after surgery

Aim. To assess the severity of heart failure (HF) 1 year after aortic valve replacement with a novel bioprosthetic valve with the “easy change” system.Material and methods. The study included 59 patients (24 men and 35 women) diagnosed with degenerative aortic valve disease without concomitant cardiac pathology. The mean age of the patients was 69,6±4,3 years. An assessment of NYHA HF class using six-minute walk test was carried out. The venous plasma level of N-terminal pro-brain natriuretric peptide (NT-proBNP) before and after surgery was also used to determine the severity of HF. In 31 patients (52,5%), NYHA class III HF was determined before surgery.Results. Comparative analysis of HF classes revealed a significant difference. Thus, after implantation of MedEng-BIO prosthetic aortic valve, the distance of the six-minute walk test increased by an average of 125 m (p=0,001). NT-proBNP level decreased from 162,2 pg/ml to 63,7 pg/ml (p=0,003).Conclusion. One-year follow-up of patients after implantation of a novel bioprosthetic aortic valve showed an objective decrease in the severity of HF according to six-minute walk test and NT-proBNP level in venous blood plasma