10,107 research outputs found
Sweet taste signaling and the formation of memories of energy sources
The last decade witnessed remarkable advances in our knowledge of the gustatory system. Application of molecular biology techniques not only determined the identity of the membrane receptors and downstream effectors that mediate sweetness, but also uncovered the overall logic of gustatory coding in the periphery. However, while the ability to taste sweet may offer the obvious advantage of eliciting rapid and robust intake of sugars, a number of recent studies demonstrate that sweetness is neither necessary nor sufficient for the formation of long-lasting preferences for stimuli associated with sugar intake. Furthermore, uncoupling sweet taste from ensuing energy utilization may disrupt body weight control. This minireview examines recent experiments performed in both rodents and Drosophila revealing the taste-independent rewarding properties of metabolizable sugars. Taken together, these experiments demonstrate the reinforcing actions of sugars in the absence of sweet taste signaling and point to a critical role played by dopamine systems in translating metabolic sensing into behavioral action. From a mechanistic viewpoint, current evidence favors the concept that gastrointestinal and post-absorptive signals contribute in parallel to sweet-independent sugar acceptance and dopamine release
Evidence for a Very Large-Scale Fractal Structure in the Universe from Cobe Measurements
In this work, we analyse the temperature fluctuations of the cosmic microwave
background radiation observed by COBE and show that the distribution can be
fitted by a fractal distribution with a fractal dimension .
This value is in close agreement with the fractal dimension obtained by Coleman
and Pietronero (1992) and Luo and Schramm (1992) from galaxy-galaxy and
cluster-cluster correlations up to . The fact that the
observed temperature fluctuations correspond to scales much larger than and are signatures of the primordial density fluctuations at the
recombination layer suggests that the structure of the matter at the early
universe was already fractal and thus non-homogeneous on those scales. This
result may have important consequences for the theoretical framework that
describes the universe.Comment: 11 pages, postscript file, 2 figures available upon request. To
appear in ApJ Letter
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