Characterisation of Cu-CNTs composite electrical properties in elevated temperatures

The current trend towards nanotechnology creates possibilities for its use in materials science as manufacturing material with extraordinary properties, and is one of the goals for scientists in this field. Carbon nanotubes in particular are promising due to their electrical, thermal and mechanical properties, which have been of interest for researchers around the world. This paper focuses on the manufacturing process of the Cu-CNT composite via powder metallurgy and KOBO extrusion process, its further cold drawing process, and electrical resistance test at an elevated temperature. As obtained data proved, the higher the CNT content the lower the electrical resistance

Spt6 is a maintenance factor for centromeric CENP-A

Replication and transcription of genomic DNA requires partial disassembly of nucleosomes to allow progression of polymerases. This presents both an opportunity to remodel the underlying chromatin and a danger of losing epigenetic information. Centromeric transcription is required for stable incorporation of the centromere-specific histone dCENP-A in M/G1 phase, which depends on the eviction of previously deposited H3/H3.3-placeholder nucleosomes. Here we demonstrate that the histone chaperone and transcription elongation factor Spt6 spatially and temporarily coincides with centromeric transcription and prevents the loss of old CENP-A nucleosomes in both Drosophila and human cells. Spt6 binds directly to dCENP-A and dCENP-A mutants carrying phosphomimetic residues alleviate this association. Retention of phosphomimetic dCENP-A mutants is reduced relative to wildtype, while non-phosphorylatable dCENP-A retention is increased and accumulates at the centromere. We conclude that Spt6 acts as a conserved CENP-A maintenance factor that ensures long-term stability of epigenetic centromere identity during transcription-mediated chromatin remodeling

Characterisation of Cu-CNTs composite electrical properties in elevated temperatures

The current trend towards nanotechnology creates possibilities for its use in materials science as manufacturing material with extraordinary properties, and is one of the goals for scientists in this field. Carbon nanotubes in particular are promising due to their electrical, thermal and mechanical properties, which have been of interest for researchers around the world. This paper focuses on the manufacturing process of the Cu-CNT composite via powder metallurgy and KOBO extrusion process, its further cold drawing process, and electrical resistance test at an elevated temperature. As obtained data proved, the higher the CNT content the lower the electrical resistance

Parental nucleosome segregation and the inheritance of cellular identity

Gene expression programmes conferring cellular identity are achieved through the organization of chromatin structures that either facilitate or impede transcription. Among the key determinants of chromatin organization are the histone modifications that correlate with a given transcriptional status and chromatin state. Until recently, the details for the segregation of nucleosomes on DNA replication and their implications in re-establishing heritable chromatin domains remained unclear. Here, we review recent findings detailing the local segregation of parental nucleosomes and highlight important advances as to how histone methyltransferases associated with the establishment of repressive chromatin domains facilitate epigenetic inheritance. Maintenance of cell-type identity requires the faithful inheritance of chromatin states through cell division, despite the challenges posed by the disruptive passage of the DNA replication fork and the dilution of nucleosome components in complex with the daughter DNA strands. In this Review, Escobar, Loyola and Reinberg discuss how methodological advances are providing unprecedented mechanistic insights into the segregation of parental nucleosomes, how these mechanisms maintain gene expression programmes and how non-faithful nucleosome segregation is linked to differentiation and disease