3,890 research outputs found
Synchronization of coupled nonidentical dynamical systems
We analyze the stability of synchronized state for coupled nearly identical
dynamical systems on networks by deriving an approximate Master Stability
Function (MSF). Using this MSF we treat the problem of designing a network
having the best synchronizability properties. We find that the edges which
connect nodes with a larger relative parameter mismatch are preferred and the
nodes having values at one extreme of the parameter mismatch are preferred as
hubs.Comment: 11 pages, 4 figure
Integrated Biologics Manufacturing in Stirred-Suspension Bioreactor: A Stem Cell Perspective
Stem cell therapy is garnering attention as several clinical trials have taken place in the recent years by using human pluripotent stem cells (hPSCs). Hundreds of biotechnological companies are investing to find a permanent cure for difficult-to-treat diseases like age-related macular degeneration, Parkinson’s disease, diabetes, etc. by using hPSCs. Therefore, clinical-grade cell manufacturing has become an important issue to make cell therapy products safe and effective. Current manufacturing practices are adopted from conventional antibody or protein production in the pharmaceutical industry where cells are used as a vector for producing the desired products. In cell therapy applications, cells are the products that are sensitive to physicochemical parameters and storage conditions anywhere between isolation to patient administration. Moreover, cell-based product manufacturing consists of multi-step processing, including isolation from patients, genetic modification, derivation, expansion, differentiation, purification, characterization, cryopreservation, etc. This can require long processing times and pose high risk of product contamination as well as high production cost. Herein, we discuss the current methods of biologics manufacturing and its limitations. We also review current practices for integrating and automating cell manufacturing facilities. Finally, we propose how to integrate multi-step cell processing in a single bioreactor to make the cell manufacturing practices more direct
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Direct Laser Fabrication of a Gas Turbine Engine Component - Microstructure and Properties - Part I
This paper presents the development of a new technique for the production of abrasive
turbine blade tips by direct laser processing. This superalloy cermet component is an integral part
of the low pressure turbine sealing system in a demonstrator engine. Direct laser fabrication of
this component fiom a bed a loose powder results in significant cost savings and improved
performance over the currently employed production technique. The technology has been
demonstrated by fabricating a prototype lot of 100 blade tips, which will be subjected to an engine
test. This is the first instance of a direct fabrication method applied to the production of functional
engine hardware. This research was funded by the United States Air Force contract F33615-94-
C-2424 titled "Affordable Turbine Blade Tips".Mechanical Engineerin
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