6,116 research outputs found
Behavioural clusters and predictors of performance during recovery from stroke
We examined the patterns and variability of recovery post-stroke in multiple behavioral domains. A large cohort of first time stroke patients with heterogeneous lesions was studied prospectively and longitudinally at 1-2 weeks, 3 months and one year post-injury with structural MRI to measure lesion anatomy and in-depth neuropsychological assessment. Impairment was described at all timepoints by a few clusters of correlated deficits. The time course and magnitude of recovery was similar across domains, with change scores largely proportional to the initial deficit and most recovery occurring within the first three months. Damage to specific white matter tracts produced poorer recovery over several domains: attention and superior longitudinal fasciculus II/III, language and posterior arcuate fasciculus, motor and corticospinal tract. Finally, after accounting for the severity of the initial deficit, language and visual memory recovery/outcome was worse with lower education, while the occurrence of multiple deficits negatively impacted attention recovery
Early diffusion evidence of retrograde transsynaptic degeneration in the human visual system
We investigated whether diffusion tensor imaging (DTI) indices of white matter integrity would offer early markers of retrograde transsynaptic degeneration (RTD) in the visual system after stroke
Objective: We investigated whether diffusion tensor imaging (DTI) indices of white matter integrity
would offer early markers of retrograde transsynaptic degeneration (RTD) in the visual system
after stroke.
Methods: We performed a prospective longitudinal analysis of the sensitivity of DTI markers of
optic tract health in 12 patients with postsynaptic visual pathway stroke, 12 stroke controls,
and 28 healthy controls. We examined group differences in (1) optic tract fractional anisotropy
(FA-asymmetry), (2) perimetric measures of visual impairment, and (3) the relationship between
FA-asymmetry and perimetric assessment.
Results: FA-asymmetry was higher in patients with visual pathway lesions than in control groups.
These differences were evident 3 months from the time of injury and did not change significantly
at 12 months. Perimetric measures showed evidence of impairment in participants with visual
pathway stroke but not in control groups. A significant association was observed between
FA-asymmetry and perimetric measures at 3 months, which persisted at 12 months.
Conclusions: DTI markers of RTD are apparent 3 months from the time of injury. This represents
the earliest noninvasive evidence of RTD in any species. Furthermore, these measures associate
with measures of visual impairment. DTI measures offer a reproducible, noninvasive, and sensitive
method of investigating RTD and its role in visual impairment
Electrometry Using Coherent Exchange Oscillations in a Singlet-Triplet-Qubit
Two level systems that can be reliably controlled and measured hold promise
in both metrology and as qubits for quantum information science (QIS). When
prepared in a superposition of two states and allowed to evolve freely, the
state of the system precesses with a frequency proportional to the splitting
between the states. In QIS,this precession forms the basis for universal
control of the qubit,and in metrology the frequency of the precession provides
a sensitive measurement of the splitting. However, on a timescale of the
coherence time, , the qubit loses its quantum information due to
interactions with its noisy environment, causing qubit oscillations to decay
and setting a limit on the fidelity of quantum control and the precision of
qubit-based measurements. Understanding how the qubit couples to its
environment and the dynamics of the noise in the environment are therefore key
to effective QIS experiments and metrology. Here we show measurements of the
level splitting and dephasing due to voltage noise of a GaAs singlet-triplet
qubit during exchange oscillations. Using free evolution and Hahn echo
experiments we probe the low frequency and high frequency environmental
fluctuations, respectively. The measured fluctuations at high frequencies are
small, allowing the qubit to be used as a charge sensor with a sensitivity of
, two orders of magnitude better than
the quantum limit for an RF single electron transistor (RF-SET). We find that
the dephasing is due to non-Markovian voltage fluctuations in both regimes and
exhibits an unexpected temperature dependence. Based on these measurements we
provide recommendations for improving in future experiments, allowing for
higher fidelity operations and improved charge sensitivity
Generational Differences in Information Technology Use and Political Involvement
A structural equation model analysis of data from a 2003 national random sample survey (n = 478) on informational technology (IT) reveals important direct and indirect effects of generational demographic and attitudinal differences on electronic forms of political participation. Younger respondents reported more support for IT and fewer technological disadvantages compared to older respondents. Younger respondents showed more desire for public IT availability and e-political participation, whereas older respondents preferred traditional electoral involvement. The more educated held more favorable views of IT generally and of public IT access more specifically. Bettereducated respondents were more active civically in both traditional and electronic forms of participation. Supportive technological views led to greater e-political participation and stronger interest in e-elections. Respondents with less concern and fear about IT were more likely to act as digital citizens and were more involved in epolitics and e-elections. Proponents of public IT access were more supportive of eelections. Our model suggests that e-citizenry will compound existing social divisions, as non-electronic voices are marginalized and electronic voices are amplified
Demonstration of Entanglement of Electrostatically Coupled Singlet-Triplet Qubits
Quantum computers have the potential to solve certain interesting problems
significantly faster than classical computers. To exploit the power of a
quantum computation it is necessary to perform inter-qubit operations and
generate entangled states. Spin qubits are a promising candidate for
implementing a quantum processor due to their potential for scalability and
miniaturization. However, their weak interactions with the environment, which
leads to their long coherence times, makes inter-qubit operations challenging.
We perform a controlled two-qubit operation between singlet-triplet qubits
using a dynamically decoupled sequence that maintains the two-qubit coupling
while decoupling each qubit from its fluctuating environment. Using state
tomography we measure the full density matrix of the system and determine the
concurrence and the fidelity of the generated state, providing proof of
entanglement
- …