Role of homocysteine metabolism in the development of endothelial dysfunction and hypertension in patients with multiple myeloma

The article is devoted to the modern understanding of endothelial dysfunction development, the role of hyperhomocysteinemia, and, as a consequence, hypertension in patients with multiple myeloma receiving multiagent chemotherapy. Considering that the potential of a standard examination does not allow identifying subclinical endothelial dysfunction, using specific techniques is necessary, in particular, to determine the homocysteine level to monitor the endothelial function.The aim of this review was to summarize the current understanding of hypertension etiology and prospects for detecting early, subclinical endothelial changes, including in patients with multiple myeloma.Assessment of endothelial dysfunction can be useful for detecting precisely the subclinical cardiovascular disease in order to stratify the risk of developing cardiovascular events in patients receiving multiagent chemotherapy

The blood-groove and the biomechanics of the pulmonary artery at patients with COLD I and II stages

The blood-groove in the pulmonary artery was studied by the method of the Echocardiography in the impulse doppler mode and the biomechanic by the method of the automated analysis rheogramma of the pulmonary artery at 23 patient with COLD l stage (GOLD, 2006) and at 35 patient with COLD ll stage. The violation of haemodynamics were realised by increase in high-speed parametres at patients with COLD l stage and lowering at patients COLD ll stage. The average pressure in the pulmonary artery authentically exceeded the normal amounts at patient both groups. The biomechanics violations were characterised hypodynamy in the systole of the pulmonary artery