Effects of omalizumab therapy on allergic rhinitis: a pilot study

The use of omalizumab, a humanized monoclonal antibody able to binding Ig-E, is currently authorized only for treatment of severe bronchial asthma. The use of omalizumab in other Ig-E related diseases is off-label, although some studies have provided promising results about it. The aim of this study was to evaluate if therapy with omalizumab in patients affected by asthma and allergic rhinitis has an impact also on allergic rhinitis-related symptoms

Electromagnetic transitions for A=3 nuclear systems

Recent advances in the study of pd radiative capture in a wide range of center-of-mass energy below and above deuteron breakup threshold are presented and discussed.Comment: Invited lead talk at the 19th European Conference on Few-Body Problems in Physics, Groningen, The Netherlands, 8/23 - 8/27 2004, 5 pages, 4 figure

Electromagnetic structure of A=2 and 3 nuclei and the nuclear current operator

Different models for conserved two- and three-body electromagnetic currents are constructed from two- and three-nucleon interactions, using either meson-exchange mechanisms or minimal substitution in the momentum dependence of these interactions. The connection between these two different schemes is elucidated. A number of low-energy electronuclear observables, including (i) $np$ radiative capture at thermal neutron energies and deuteron photodisintegration at low energies, (ii) $nd$ and $pd$ radiative capture reactions, and (iii) isoscalar and isovector magnetic form factors of $^3$H and $^3$He, are calculated in order to make a comparative study of these models for the current operator. The realistic Argonne $v_{18}$ two-nucleon and Urbana IX or Tucson-Melbourne three-nucleon interactions are taken as a case study. For $A$=3 processes, the bound and continuum wave functions, both below and above deuteron breakup threshold, are obtained with the correlated hyperspherical-harmonics method. Three-body currents give small but significant contributions to some of the polarization observables in the $^2$H($p,\gamma$)$^3$He process and the $^2$H($n,\gamma$)$^3$H cross section at thermal neutron energies. It is shown that the use of a current which did not exactly satisfy current conservation with the two- and three-nucleon interactions in the Hamiltonian was responsible for some of the discrepancies reported in previous studies between the experimental and theoretical polarization observables in $pd$ radiative capture.Comment: 48 pages, 25 figures, 4 tables, revtex4. Submitted to Phys. Rev.

Chiral effective field theory predictions for muon capture on deuteron and 3He

The muon-capture reactions 2H(\mu^-,\nu_\mu)nn and 3He(\mu^-,\nu_\mu)3H are studied with nuclear strong-interaction potentials and charge-changing weak currents, derived in chiral effective field theory. The low-energy constants (LEC's) c_D and c_E, present in the three-nucleon potential and (c_D) axial-vector current, are constrained to reproduce the A=3 binding energies and the triton Gamow-Teller matrix element. The vector weak current is related to the isovector component of the electromagnetic current via the conserved-vector-current constraint, and the two LEC's entering the contact terms in the latter are constrained to reproduce the A=3 magnetic moments. The muon capture rates on deuteron and 3He are predicted to be 399(3) sec^{-1} and 1494 (21) sec^{-1}, respectively, where the spread accounts for the cutoff sensitivity as well as uncertainties in the LEC's and electroweak radiative corrections. By comparing the calculated and precisely measured rates on 3He, a value for the induced pseudoscalar form factor is obtained in good agreement with the chiral perturbation theory prediction.Comment: 4 pages, 2 figures, revisited version accepted for publication on Phys. Rev. Let

Electrodisintegration of 3^3He below and above deuteron breakup threshold

Recent advances in the study of electrodisintegration of 3He are presented and discussed. The pair-correlated hyperspherical harmonics method is used to calculate the initial and final state wave functions, with a realistic Hamiltonian consisting of the Argonne v18 two-nucleon and Urbana IX three-nucleon interactions. The model for the nuclear current and charge operators retains one- and many-body contributions. Particular attention is made in the construction of the two-body current operators arising from the momentum-dependent part of the two-nucleon interaction. Three-body current operators are also included so that the full current operator is strictly conserved. The present model for the nuclear current operator is tested comparing theoretical predictions and experimental data of pd radiative capture cross section and spin observables.Comment: 5 pages, 5 figures, submitted to Eur. Phys. J.

Proton-3He elastic scattering at low energies and the "A_y Puzzle"

The Kohn variational principle and the hyperspherical harmonic technique are applied to study p-3He elastic scattering at low energies. Preliminary results obtained using several interaction models are reported. The calculations are compared to a recent phase shift analysis performed at the Triangle University Nuclear Laboratory and to the available experimental data. Using a three-nucleon interaction derived from chiral perturbation theory at N2LO, we have found a noticeable reduction of the discrepancy observed for the A_y observable.Comment: 9 pages, 9 figures, to be published in the Proceedings of the 19th International IUPAP Conference on Few-Body Problems in Physics, Bonn, 200

Weak proton capture on 3He

The astrophysical S-factor for the proton weak capture on 3He is calculated with correlated-hyperspherical-harmonics bound and continuum wave functions corresponding to realistic Hamiltonians consisting of the Argonne v14 or Argonne v18 two-nucleon and Urbana-VIII or Urbana-IX three-nucleon interactions. The nuclear weak charge and current operators have vector and axial-vector components, that include one- and many-body terms. All possible multipole transitions connecting any of the p 3He S- and P-wave channels to the 4He bound state are considered. The S-factor at a p 3He center-of-mass energy of 10 keV, close to the Gamow-peak energy, is predicted to be 10.1 10^{-20} keV b with the AV18/UIX Hamiltonian, a factor of about 4.5 larger than the value adopted in the standard solar model. The P-wave transitions are found to be important, contributing about 40 % of the calculated S-factor. The energy dependence is rather weak: the AV18/UIX zero-energy S-factor is 9.64 10^{-20} keV b, only 5 % smaller than the 10 keV result quoted above. The model dependence is also found to be weak: the zero-energy S-factor is calculated to be 10.2 10^{-20} keV b with the older AV14/UVIII model, only 6 % larger than the AV18/UIX result. Our best estimate for the S-factor at 10 keV is therefore (10.1 \pm 0.6) 10^{-20} keV b, when the theoretical uncertainty due to the model dependence is included. This value for the calculated S-factor is not as large as determined in fits to the Super-Kamiokande data in which the hep flux normalization is free. However, the precise calculation of the S-factor and the consequent absolute prediction for the hep neutrino flux will allow much greater discrimination among proposed solar neutrino oscillation solutions.Comment: 54 pages RevTex file, 6 PostScript figures, submitted to Phys. Rev.

Hard x-ray broad band Laue lenses (80 - 600 keV): building methods and performances

We present the status of the laue project devoted to develop a technology for building a 20 meter long focal length Laue lens for hard x-/soft gamma-ray astronomy (80 - 600 keV). The Laue lens is composed of bent crystals of Gallium Arsenide (GaAs, 220) and Germanium (Ge, 111), and, for the first time, the focusing property of bent crystals has been exploited for this field of applications. We show the preliminary results concerning the adhesive employed to fix the crystal tiles over the lens support, the positioning accuracy obtained and possible further improvements. The Laue lens petal that will be completed in a few months has a pass band of 80 - 300 keV and is a fraction of an entire Laue lens capable of focusing X-rays up to 600 keV, possibly extendable down to 20 - 30 keV with suitable low absorption crystal materials and focal length. The final goal is to develop a focusing optics that can improve the sensitivity over current telescopes in this energy band by 2 orders of magnitude