1,530 research outputs found
Resonant Excitation of White Dwarf Oscillations in Compact Object Binaries: 1. The No Back Reaction Approximation
We consider the evolution of white dwarfs with compact object companions
(specifically black holes with masses up to 10^6 solar masses, neutron stars,
and other white dwarfs). We suppose that the orbits are initially quite
elliptical and then shrink and circularise under the action of gravitational
radiation. During this evolution, the white dwarfs will pass through resonances
when harmonics of the orbital frequency match the stellar oscillation
eigenfrequencies. As a star passes through these resonances, the associated
modes will be excited and can be driven to amplitudes that are so large that
there is a back reaction on the orbit which, in turn, limits the growth of the
modes. A formalism is presented for describing this dynamical interaction for a
non-rotating star in the linear approximation when the orbit can be treated as
non-relativistic. A semi-analytical expression is found for computing the
resonant energy transfer as a function of stellar and orbital parameters for
the regime where back reaction may be neglected. This is used to calculate the
results of passage through a sequence of resonances for several hypothetical
systems. It is found that the amplitude of the l=m=2 f-mode can be driven into
the non-linear regime for appropriate initial conditions. We also discuss where
the no back reaction approximation is expected to fail, and the qualitative
effects of back reaction.Comment: 14 pages, 4 figures. Figure 3 corrected. Accepted for publication in
MNRA
A multi-dimensional, adiabatic, hydrodynamics code for studying tidal excitation
We have developed a parallel, simple, and fast hydrodynamics code for
multi-dimensional, self-gravitating, adiabatic flows. Our primary motivation is
the study of the non-linear evolution of white dwarf oscillations excited via
tidal resonances, typically over hundreds of stellar dynamical times.
Consequently, we require long term stability, low diffusivity, and high
algorithmic efficiency. An explicit, Eulerian, finite-difference scheme on a
regular Cartesian grid fulfills these requirements. It provides uniform
resolution throughout the flow, as well as simplifying the computation of the
self-gravitational potential, which is done via spectral methods. In this
paper, we describe the numerical scheme and present the results of some
diagnostic problems. We also demonstrate the stability of a cold white dwarf in
three dimensions over hundreds of dynamical times. Finally, we compare the
results of the numerical scheme to the linear theory of adiabatic oscillations,
finding numerical quality factors on the order of 6000, and excellent agreement
with the oscillation frequency obtained by the linear analysis.Comment: 11 pages, 10 figure
Charge Delocalization in Self-Assembled Mixed-Valence Aromatic Cation Radicals
The spontaneous assembly of aromatic cation radicals (D+âą) with their neutral counterpart (D) affords dimer cation radicals (D2+âą). The intermolecular dimeric cation radicals are readily characterized by the appearance of an intervalence charge-resonance transition in the NIR region of their electronic spectra and by ESR spectroscopy. The X-ray crystal structure analysis and DFT calculations of a representative dimer cation radical (i.e., the octamethylbiphenylene dimer cation radical) have established that a hole (or single positive charge) is completely delocalized over both aromatic moieties. The energetics and the geometrical considerations for the formation of dimer cation radicals is deliberated with the aid of a series of cyclophane-like bichromophoric donors with drastically varied interplanar angles between the cofacially arranged aryl moieties. X-ray crystallography of a number of mixed-valence cation radicals derived from monochromophoric benzenoid donors established that they generally assemble in 1D stacks in the solid state. However, the use of polychromophoric intervalence cation radicals, where a single charge is effectively delocalized among all of the chromophores, can lead to higher-order assemblies with potential applications in long-range charge transport. As a proof of concept, we show that a single charge in the cation radical of a triptycene derivative is evenly distributed on all three benzenoid rings and this triptycene cation radical forms a 2D electronically coupled assembly, as established by X-ray crystallography
Plasmodium falciparum OTUâlike cysteine protease (PfOTU) is essential for apicoplast homeostasis and associates with noncanonical role of Atg8
The metabolic pathways associated with the mitochondrion and the apicoplast in Plasmodium, 2 parasite organelles of prokaryotic origin, are considered as suitable drug targets. In the present study, we have identified functional role of a novel ovarian tumour unit (OTU) domain-containing cysteine protease of Plasmodium falciparum (PfOTU). A C-terminal regulatable fluorescent affinity tag on native protein was utilised for its localization and functional characterization. Detailed studies showed vesicular localization of PfOTU and its association with the apicoplast. Degradation-tag mediated knockdown of PfOTU resulted in abnormal apicoplast development and blocked development of parasites beyond early-schizont stages in subsequent cell cycle; downregulation of PfOTU hindered apicoplast protein import. Further, the isoprenoid precursor-mediated parasite growth-rescue experiments confirmed that PfOTU knockdown specifically effect development of functional apicoplast. We also provide evidence for a possible biological function of PfOTU in membrane deconjugation of Atg8, which may be linked with the apicoplast protein import. Overall, our results show that the PfOTU is involved in apicoplast homeostasis and associates with the noncanonical function of Atg8 in maintenance of parasite apicoplast
Gene action of blast disease reaction and grain yield traits in finger millet
Gene action of blast reaction, yield and yield associated traits in finger millet were studied using a 4x4 North Carolina Design II mating scheme. The four female and four male parents and their 16 crosses were evaluated at Alupe and Kakamega in western Kenya in a randomized complete block design under both artificially induced and natural disease pressure. General combining ability (GCA) and specific combining ability (SCA) estimates of the traits were calculated to determine the genotypes breeding value. The GCA variance predominated over SCA variance for all traits except finger width hence these traits can be improved through selection. With high, desirable GCA effects, male parent KNE 392 and female parents KNE 744 and IE 11 are suitable for blast resistance breeding while male parent Okhale 1 is suitable for grain yield improvement. The frequency distribution for the segregating F2 generation for the three blast types differed within and between crosses which could be due to differences in gene numbers or gene combinations being expressed in the different parents used. Convergent crossing or gene pyramiding for durable resistance could be possible
Near-surface salinity reveals the oceanic sources of moisture for Australian precipitation through atmospheric moisture transport
Author Posting. © American Meteorological Society, 2020. This article is posted here by permission of American Meteorological Society for personal use, not for redistribution. The definitive version was published in Journal of Climate 33(15), (2020): 6707-6730, https://doi.org/10.1175/JCLI-D-19-0579.1.The long-term trend of sea surface salinity (SSS) reveals an intensification of the global hydrological cycle due to human-induced climate change. This study demonstrates that SSS variability can also be used as a measure of terrestrial precipitation on interseasonal to interannual time scales, and to locate the source of moisture. Seasonal composites during El NiñoâSouthern Oscillation/Indian Ocean dipole (ENSO/IOD) events are used to understand the variations of moisture transport and precipitation over Australia, and their association with SSS variability. As ENSO/IOD events evolve, patterns of positive or negative SSS anomaly emerge in the Indo-Pacific warm pool region and are accompanied by atmospheric moisture transport anomalies toward Australia. During co-occurring La Niña and negative IOD events, salty anomalies around the Maritime Continent (north of Australia) indicate freshwater export and are associated with a significant moisture transport that converges over Australia to create anomalous wet conditions. In contrast, during co-occurring El Niño and positive IOD events, a moisture transport divergence anomaly over Australia results in anomalous dry conditions. The relationship between SSS and atmospheric moisture transport also holds for pure ENSO/IOD events but varies in magnitude and spatial pattern. The significant pattern correlation between the moisture flux divergence and SSS anomaly during the ENSO/IOD events highlights the associated oceanâatmosphere coupling. A case study of the extreme hydroclimatic events of Australia (e.g., the 2010/11 Brisbane flood) demonstrates that the changes in SSS occur before the peak of ENSO/IOD events. This raises the prospect that tracking of SSS variability could aid the prediction of Australian rainfall.This research is funded through the Earth System and Climate Change Hub of the Australian governmentâs National Environmental Science Programme. The assistance of computing resources from the National Computational Infrastructure supported by the Australian Government is acknowledged. CCU acknowledges support from the U.S. National Science Foundation under Grant OCE-1663704. MF was supported by the by Centre for Southern Hemisphere Oceans Research (CSHOR), which is a joint initiative between the Qingdao National Laboratory for Marine Science and Technology (QNLM), CSIRO, University of New South Wales and University of Tasmania. The authors wish to acknowledge PyFerret (https://ferret.pmel.noaa.gov/Ferret/) and the Cimate Data Operators (https://code.mpimet.mpg.de/projects/cdo/) for the data analysis and graphical representations in this paper
Factors influencing patient willingness to participate in genetic research after a myocardial infarction
Abstract
Background
Achieving 'personalized medicine' requires enrolling representative cohorts into genetic studies, but patient self-selection may introduce bias. We sought to identify characteristics associated with genetic consent in a myocardial infarction (MI) registry.
Methods
We assessed correlates of participation in the genetic sub-study of TRIUMPH, a prospective MI registry (n = 4,340) from 24 US hospitals between April 2005 and December 2008. Factors examined included extensive socio-demographics factors, clinical variables, and study site. Predictors of consent were identified using hierarchical modified Poisson regression, adjusting for study site. Variation in consent rates across hospitals were quantified by the median rate ratio (MRR).
Results
Most subjects consented to donation of their genetic material (n = 3,484; 80%). Participation rates varied greatly between sites, from 40% to 100%. After adjustment for confounding factors, the MRR for hospital was 1.22 (95% confidence interval (CI) 1.11 to 1.29). The only patient-level factors associated with consent were race (RR 0.93 for African Americans versus whites, 95% CI 0.88 to 0.99) and body mass index (RR 1.03 for BMI ≥ 25, 95% CI 1.01 to 1.06).
Conclusion
Among patients with an MI there were notable differences in genetic consent by study site, but little association with patient-level factors. This suggests that variation in the way information is presented during recruitment, or other site factors, strongly influence patients' decision to participate in genetic studies.Peer Reviewe
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