Dynamics of topological defects in ion Coulomb crystals

We study experimentally and theoretically the properties of structural defects (kink solitons) in two-dimensional ion Coulomb crystals. We show how different types of kink solitons with different physical properties can be realized, and transformed from one type into another by varying the aspect ratio of the trap confinement. Further, we discuss how impurities in ion Coulomb crystals, such as mass defects, can modify the dynamics of kink creation and their stability. For both pure and impure crystals, the experimentally observed kink dynamics are analyzed in detail and explained theoretically by numerical simulations and calculations of the Peierls-Nabarro potential. Finally, we show that static electric fields provide a handle to vary the influence of mass defects on kinks in a controlled way and allow for deterministic manipulation and creation of kinks.Comment: 21 pages, 8 figure

A modern research for the Turkish ethnography

The urgency of the problem under study is caused by the need to consider the achievements of field researchers of the XIXth century from the standpoint of modern science. The purpose of the article is to characterize the research method of the ethnographer and folklorist Nikolai Katanov (1862-1922). The historical-genetic method is the leading one to the study of this problem. The main results of the research consist in the systematization of the unrecognized intellectual heritage from N. Katanov to the end and its analysis in the context of contemporary Turkish studies. The article is of interest to the experts who are involved in Eurasian studies, the history of Russia, the history of Oriental studies, anthropology and ethnography of the Turkish people of Central Asia.peer-reviewe

Teaching of Asian languages

The article presents the main stages and directions of East education and science establishment and development in Kazan during the nineteenth and early twentieth centuries. They showed the role of the Kazan Gymnasium in the environment development for the training of experts in Eastern languages and their relevance in the academic environment of Russia during the 18th - 19th centuries. An important reason for the authority of the Kazan school on Oriental studies was the attention to the classical component and the priority of Oriental language practical study. The activities of the First Kazan Men's Gymnasium, opened in 1758, became the most important for the training of oriental personnel for the needs of the Ministry of Education, the Asian Department of the Ministry of Foreign Affairs and other Russian educational and scientific centers of the empire. The origins of Russian oriental studies were represented by the educational programs of the First Kazan Gymnasium associated with the Eastern languages, which became the basis for the research and humanistic traditions of Russian Oriental studies.peer-reviewe

EXPERIENCES OF PARENTS IN TEACHING SELF-HELP SKILLS TO LEARNERS WITH INTELLECTUAL DISABILITY DURING THE COVID-19 PANDEMIC

The main concern in education and its goal for all learners with Intellectual Disability (ID) is to continue providing learning continuity for them to be functional individuals amidst the COVID-19 pandemic. This study delved into teachers' experiences in teaching self-help skills to learners with intellectual disabilities during the pandemic in the Division of Toledo City. Using an interpretative phenomenological analysis (IPA), a qualitative research method was utilized to gather data from the parents/guardians selected through purposive random sampling to determine the parents' experiences in teaching self-help skills to learners with Intellectual Disability (ID). The results revealed that parents had more positive experiences than negative experiences in teaching their children with ID self-help skills during the pandemic. Furthermore, the challenges they encountered included teaching special education, which is tough and about following the teacher’s instructions, while the coping mechanisms were teaching through modeling and following the instructions in the module. With the foregoing, it is therefore true that the involvement of the parents in teaching children with Intellectual Disability (ID) greatly affects the learners. The participation of parents in schools can help promote positive behaviors among children. Hence, it is recommended that school administrators and other policymakers encourage activities that would support the families of learners with intellectual disability (ID).  Article visualizations

Electrophilic PPARγ Ligands Attenuate IL-1β and Silica-Induced Inflammatory Mediator Production in Human Lung Fibroblasts via a PPARγ-Independent Mechanism

Acute and chronic lung inflammation is associated with numerous important disease pathologies including asthma, chronic obstructive pulmonary disease and silicosis. Lung fibroblasts are a novel and important target of anti-inflammatory therapy, as they orchestrate, respond to, and amplify inflammatory cascades and are the key cell in the pathogenesis of lung fibrosis. Peroxisome proliferator-activated receptor gamma (PPARγ) ligands are small molecules that induce anti-inflammatory responses in a variety of tissues. Here, we report for the first time that PPARγ ligands have potent anti-inflammatory effects on human lung fibroblasts. 2-cyano-3, 12-dioxoolean-1, 9-dien-28-oic acid (CDDO) and 15-deoxy-Δ12,14-prostaglandin J2 (15d-PGJ2) inhibit production of the inflammatory mediators interleukin-6 (IL-6), monocyte chemoattractant protein-1 (MCP-1), COX-2, and prostaglandin (PG)E2 in primary human lung fibroblasts stimulated with either IL-1β or silica. The anti-inflammatory properties of these molecules are not blocked by the PPARγ antagonist GW9662 and thus are largely PPARγ independent. However, they are dependent on the presence of an electrophilic carbon. CDDO and 15d-PGJ2, but not rosiglitazone, inhibited NF-κB activity. These results demonstrate that CDDO and 15d-PGJ2 are potent attenuators of proinflammatory responses in lung fibroblasts and suggest that these molecules should be explored as the basis for novel, targeted anti-inflammatory therapies in the lung and other organs