Firm Size and the Information Content of Over-the-Counter Common Stock Offerings

We examine the announcement period of stock returns for 179 over-the-counter (OTC) firms that issue common stock to reduce nonconvertible debt. We find that small OTC firms experience returns that are significantly more negative than large OTC firms. Regression tests reveal that firm size is a significant factor in accounting for stock returns. Other tests establish as firm size a dominant effect. Our support for a firm size effect is consistent with a differential information effect given that firm size is positively related to the amount of information available about firms

Genome-wide profiling of chromosome interactions in Plasmodium falciparum characterizes nuclear architecture and reconfigurations associated with antigenic variation.

Spatial relationships within the eukaryotic nucleus are essential for proper nuclear function. In Plasmodium falciparum, the repositioning of chromosomes has been implicated in the regulation of the expression of genes responsible for antigenic variation, and the formation of a single, peri-nuclear nucleolus results in the clustering of rDNA. Nevertheless, the precise spatial relationships between chromosomes remain poorly understood, because, until recently, techniques with sufficient resolution have been lacking. Here we have used chromosome conformation capture and second-generation sequencing to study changes in chromosome folding and spatial positioning that occur during switches in var gene expression. We have generated maps of chromosomal spatial affinities within the P. falciparum nucleus at 25 Kb resolution, revealing a structured nucleolus, an absence of chromosome territories, and confirming previously identified clustering of heterochromatin foci. We show that switches in var gene expression do not appear to involve interaction with a distant enhancer, but do result in local changes at the active locus. These maps reveal the folding properties of malaria chromosomes, validate known physical associations, and characterize the global landscape of spatial interactions. Collectively, our data provide critical information for a better understanding of gene expression regulation and antigenic variation in malaria parasites

Diasporic Dreams, Middle Class Moralities and Migrant Domestic Workers among Muslim Filipinos in Saudi Arabia

This paper is about middle-class Muslim Filipinos in Saudi Arabia and their discourses about and relationships with migrant domestic workers. Saudi Arabia is not simply a temporary stopping point to a better future elsewhere, but is also a place where the middle-class aspirations of Muslim Filipinos may be realised and where their religious affiliations as Muslims may be seen as enhancing rather than detracting from those dreams and imaginings. As part of a large and diverse diasporic community, middle-class Filipinos routinely interact and socialise with working-class Filipinos. They often provide succour and support for their compatriots who labour under difficult and legally unprotected conditions. Some employ migrant domestic workers in their homes, many of whom are irregular or takas (escapees). At the same time, they reproduce and reinforce many of the gendered stereotypes of domestic workers that often suggest moral failings of one sort or another. The simultaneous embracing of and distancing from domestic workers reflects the anxieties of those, particularly women, whose tenuous hold of middle-class status is accomplished through, but also put at risk by, the precariousness of their sojourns abroad in the Kingdom