Twenty-four-hour blood pressure profile in polycystic kidney disease

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EFFECTS OF A MIXED PHYSICAL-ACTIVITY (BIATHLON) ON HEMATOLOGIC PARAMETERS, RED-CELL 2,3-DPG AND CREATINE, SERUM ERYTHROPOIETIN, URINARY ENZYMES AND MICROALBUMIN

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EFFECTS OF EXERCISE ON HEMATOLOGIC PARAMETERS, SERUM IRON, SERUM FERRITIN, RED-CELL 2,3-DIPHOSPHOGLYCERATE AND CREATINE CONTENTS, AND SERUM ERYTHROPOIETIN IN LONG-DISTANCE RUNNERS DURING BASAL TRAINING

We studied 18 well-trained male long-distance runners during the basal training. Haematologic parameters, serum iron and ferritin, red cell 2,3-diphosphoglycerate (2,3-DPG) and creatine contents, serum erythropoietin were investigated before and after the daily training and were compared with a group of healthy untrained controls. Red blood cell parameters did not change with the training, even though they were significantly lower than in controls. However, a true anaemic state cannot be suggested because the haemoglobin values fell into the lower limit of the normal range, even before the exercise. A slight but significant increase of neutrophils was found after the exercise, while no alteration of platelet count was observed. Serum iron and ferritin ranged normally. No increase of red cell 2,3-DPG was observed after the exercise, but it was significantly higher than in controls. After the exercise red creatinine was slightly increased. The athletes' erythropoietin was higher than that of controls, and showed a further increase after the training

EFFECTS OF THE RECOMBINANT-HUMAN-ERYTHROPOIETIN (RHUEPO) ADMINISTRATION ON HEMATOLOGIC PARAMETERS, RED-CELL CREATINE AND 2,3-DIPHOSPHOGLYCERATE CONTENTS, IN PATIENTS AFFECTED BY END-STAGE RENAL-DISEASE

Twenty patients with renal failure and severe anemia (hemoglobin range 6.6-8.7 g/dl) on thrice-weekly maintenance hemodialysis were treated with recombinant human erythropoietin (rHuEPO). After three months of intravenous (iv) therapy the hemoglobin increase averaged 2 g/dl, and was steadily maintained even after two months of subcutaneous (sc) therapy. The significant increase of macrocyte counts, determined by an automated red blood cell counter after both steps of therapy, suggested the release of young red cells (large cells) into blood circulation. This assumption may be supported by the significant increase of the red cell creatine contents. 2,3-diphosphoglycerate (2,3-DPG) levels of the erythrocytes did not significantly change after rHuEPO administration

ERYTHROPOIETIN IN ATHLETES OF ENDURANCE EVENTS

We evaluated serum Erythropoietin (Ep), hemoglobin (Hb), hematocrit (Ht) during prolonged and strenuous exercis. The blood samples were collected fron 18 long-distance runnersand from 11 cross-country skiers, before and after a competition. Hb and Ht values decreased more in runners than in skiers, probably due to the footstrike hemolysis mechanism, stimulating kidney Ep overproduction