OER nelle Università italiane: primi risultati di un'indagine conoscitiva del Gruppo CRUI OA-OER

Le OER si inseriscono nell'ambito del movimento Open Access e dell'accesso aperto alla conoscenza, ritenuta come bene comune e prevedono licenze aperte costruite nel rispetto dei diritti di proprietà intellettuale dell’autore come stabilito dalle convenzioni internazionali e dalle normative europee e nazionali. All’inizio del 2006, nell’ambito della Commissione biblioteche della CRUI, è stato costituito il Gruppo di lavoro per l’Open Access, coordinato dal prof. Roberto Delle Donne, con il compito di dare attuazione ai principi della Dichiarazione di Berlino. Il Gruppo CRUI Open Access ha creato un sottogruppo OER. Durante l'avvio della discussione del Sottogruppo OA-OER, ci si è accordati sull'idea di realizzare un'indagine e di creare una mappa dello stato dell'arte di OER in Italia. Il contributo presenta i primi risultati dell'indagine sulle OER nelle Università italiane

Liraglutide Improves Cardiovascular Risk as an Add-on to Metformin and Not to Insulin Secretagogues in Type 2 Diabetic Patients: A Real-life 48-Month Retrospective Study.

INTRODUCTION: Although liraglutide is widely recognized to have glycemic and extra-glycemic effects, few studies have compared these effects in relation to hypoglycemic treatment starting from the diagnosis of diabetes. We evaluated the effectiveness of liraglutide in reducing the Framingham risk score (FRS) and visceral adiposity index (VAI) in relation to first-line hypoglycemic treatment from diagnosis of type 2 diabetes, continued without any changes. METHODS: We selected 105 diabetic outpatients who were treated with liraglutide for at least 48 months as an add-on therapy to metformin alone (group A, n = 52) or insulin secretagogues (group B, n = 53) from diagnosis time. RESULTS: Although both groups showed a reduction in BMI, waist circumference, blood pressure, HbA1c and triglycerides, only group A showed a significant reduction in FRS (p < 0.001) and VAI (p = 0.012) after 48 months. No significant intergroup difference was found for any parameters at either baseline or 48 months, with the exception of FRS at 48 months, lower in group A (p = 0.002), regardless of duration of disease, improvement in glycemic control and VAI. CONCLUSION: Our data show that during a 48-month follow-up liraglutide was more efficacious in reducing cardiovascular risk than when it was used as add-on therapy to the first-line therapy from diagnosis with metformin and not with insulin secretagogues

Diabetic foot ulcers: Retrospective comparative analysis from Sicily between two eras

Aim: The aim of this study was to analyze changes in the incidence, management and mortality of DFU in Sicilian Type 2 diabetic patients hospitalized between two eras, i.e. 2008-2013 and 2014-2019. Methods: We compared the two eras, era1: 2008-13, era2: 2014-19. In era 1, n = 149, and in era 2, n = 181 patients were retrospectively enrolled. Results: In the population hospitalized for DFU in 2008-2013, 59.1% of males and 40.9% of females died, whilst in 2014-2019 65.9% of males and 34.1% of females died. Moderate chronic kidney disease (CKD) was significantly higher in patients that had died than in ones that were alive (33% vs. 43%, p < 0.001), just as CKD was severe (14.5% vs. 4%, p < 0.001). Considering all together the risk factors associated with mortality, at Cox regression multivariate analysis only moderate-severe CKD (OR 1.61, 95% CI 1.07-2.42, p 0.021), age of onset greater than 69 years (OR 2.01, 95% CI 1.37-2.95, p <0.001) and eGFR less than 92 ml/min (OR 2.84, 95% CI 1.51-5.34, p 0.001) were independently associated with risk of death. Conclusions: Patients with DFU have high mortality and reduced life expectancy. Age at onset of diabetic foot ulcer, eGFR values and CKD are the principal risk factors for mortality

Developing pedagogical expertise in modern language learning and specific learning difficulties through collaborative and open educational practices

This paper analyses teachers’ engagement with collaborative and open educational practices to develop their pedagogical expertise in the field of modern language (ML) learning and specific learning difficulties (SpLD). The study analyses the findings of a staff development initiative at the Department of Languages, Open University, UK, in 2013, that aimed to support language teachers in distance learning to develop a better understanding of key issues in relation to MLs and adult learners with SpLD and dyslexia in particular. It discusses the motivational benefits of online collaboration for teachers’ professional development and explains the implications of using a range of network-based tools to facilitate the construction of active shared learning and the joint production of open-access learning resources aimed at supporting adult language learners with SpLD in distance learning settings

Retrofitting of Slender Masonry Arch Bridges

There is a large stock of masonry arch bridges built more than 100 years ago that are still in use in the world roadway and railway network. The restoration and conservation of this type of structures has become one of the main challenges of bridge engineering. As a first step, any intervention strategy requires an early stage consisting in the assessment of the structural safety (in the actual condition) of the masonry bridge. Only after that stage is performed, it is possible to design, if required, optimal repair interventions to bring the bridge to adequate safety level. In the first part of this paper, the seismic vulnerability assessment of a slender multi-span masonry arch bridge is presented. Results show that it is required to increase the flexural capacity of the structure. In the second part, an innovative intervention technique intended to increase the capacity of masonry arches is discussed. The proposed intervention technique consists on applying a layer of steel fiber reinforced mortar (SFRM) on the arch intrados. The behavior of a masonry arch strengthened with this technique is discussed by means of experimental and analytical results