Fiscal year 1991 report on archaeological surveys of the 100 Areas, Hanford Site, Washington

In compliance with Section 106 of the National Historic Preservation Act (NHPA), and at the request of Westinghouse Hanford Company, the Hanford Cultured Resources Laboratory (HCRL) conducted an archaeological survey during FY 1991 of the 100-Area reactor compounds on the US Department of Energy's Hanford Site. This survey was conducted as part of a comprehensive resources review of 100-Area Comprehensive Environmental Response, Compensation, and Liability Act (CERCLA) operable units in support of CERCLA characterization activities. The work included a lite and records review and pedestrian survey of the project area following procedures set forth in the Hanford Cultural Resources Management Plan

Hanford Cultural Resources Laboratory annual report for fiscal year 1989

This report summarizes activities of the Hanford Cultural Resources Laboratory (HCRL) during fiscal year 1989. The HCRL provides support for managing the archaeological, historical, and cultural resources of the Hanford Site, Washington, in a manner consistent with the National Historic Preservation Act of 1966, the Archaeological Resources Protection Act of 1979, and the American Indian Religious Freedom Act of 1978. A major task in FY 1989 was completion and publication of the Hanford Cultural Resources Management Plan, which prioritizes tasks to be undertaken to bring the US Department of Energy -- Richland Operations into compliance with federal statutes, relations, and guidelines. During FY 1989, six tasks were performed. In order of priority, these were conducting 107 cultural resource reviews, monitoring the condition of 40 known prehistoric archaeological sites, assessing the condition of artifact collections from the Hanford Site, evaluating three sites and nominating two of those to the National Register of Historic Places, developing an education program and presenting 11 lectures to public organizations, and surveying approximately 1 mi{sup 2} of the Hanford Site for cultural resources. 7 refs., 4 figs., 4 tabs

Hanford Cultural Resources Laboratory annual report for fiscal year 1990

The Hanford Cultural Resources Laboratory (HCRL) was established by the US Department of Energy Field Office, Richland (RL) in 1987 as part of Pacific Northwest Laboratory. The HCRL provides support for managing the archaeological, historical, and cultural resources of the Hanford Site, Washington, in a manner consistent with federal statutes and regulations. This report summarizes activities of the HCRL during fiscal year (FY) 1990. The HCRL responsibilities have been set forth in the Hanford Cultural Resources Management Plan (HCRMP) as a prioritized list of tasks. The task list guided cultural resources management activities during FY 1990 and is the outline for this report. In order, these tasks were to (1) conduct cultural resource reviews, (2) develop an archaeological resources protection plan, (3) monitor the condition of known archaeological sites, (4) plan a curation system for artifacts and records, (5) evaluate cultural resources for potential nomination to the National Register of Historic Places, (6) educate the public about cultural resources, (7) conduct a sample archaeological survey of Hanford lands, and (8) gather ethnohistorical data from Native American elders

Novel tricyclics (e.g., GSK945237) as potent inhibitors of bacterial type IIA topoisomerases

During the course of our research on the lead optimisation of the NBTI (Novel Bacterial Type II Topoisomerase Inhibitors) class of antibacterials, we discovered a series of tricyclic compounds that showed good Gram-positive and Gram-negative potency. Herein we will discuss the various subunits that were investigated in this series and report advanced studies on compound 1 (GSK945237) which demonstrates good PK and in vivo efficacy properties

Novel hydroxyl tricyclics (e.g., GSK966587) as potent inhibitors of bacterial type IIA topoisomerases

During the course of our research to find novel mode of action antibacterials, we discovered a series of hydroxyl tricyclic compounds that showed good potency against Gram-positive and Gram-negative pathogens. These compounds inhibit bacterial type IIA topoisomerases. Herein we will discuss structure–activity relationships in this series and report advanced studies on compound 1 (GSK966587) which demonstrates good PK and in vivo efficacy properties. X-ray crystallographic studies were used to provide insight into the structural basis for the difference in antibacterial potency between enantiomers