Star formation in the central regions of galaxies

Massive star formation in the central regions of spiral galaxies plays an important role in the dynamical and secular evolution of their hosts. Here, we summarise a number of recent investigations of the star formation history and the physical conditions of the gas in circumnuclear regions, to illustrate not only the detailed results one can achieve, but also the potential of using state-of-the-art spectroscopic and analysis techniques in researching the central regions of galaxies in general. We review how the star formation history of nuclear rings confirms that they are long-lived and stable configurations. Gas flows in from the disk, through the bar, and into the ring, where successive episodes of massive star formation occur. Analysing the ring in NGC 7742 in particular, we determine the physical conditions of the line emitting gas using a combination of ionisation and stellar population modelling, concluding that the origin of the nuclear ring in this non-barred galaxy lies in a recent minor merger with a small gas-rich galaxy.Comment: Invited contribution, to appear in "Mapping the Galaxy and other galaxies", Eds. K. Wada and F. Combes, Springer, in pres

New strategy for the cleaning of paper artworks: A smart combination of gels and biosensors

n this work an outlook on the design and application, in the cultural heritage field, of new tools for diagnostic and cleaning use, based on biocompatible hydrogels and electrochemical sensors, is reported. The use of hydrogels is intriguing because it does not require liquid treatment that could induce damage on artworks, while electrochemical biosensors not only are easy to prepare, but also can be selective for a specific compound and therefore are suitable for monitoring the cleaning process. In the field of restoration of paper artworks, more efforts have to be done in order to know how to perform the best way for an effective restoration. Rigid Gellan gel, made up of Gellan gum and calcium acetate, was proposed as a paper cleaning treatment, and selective biosensors for substances to be removed from this gel have been obtained by choosing the appropriate enzymes to be immobilized. Using this approach, it is possible to know when the cleanup process will be completed, avoiding lengthy and sometimes unnecessary cleaning material applications

A Connection between Star Formation in Nuclear Rings and their Host Galaxies

We present results from a photometric H-alpha survey of 22 nuclear rings, aiming to provide insight into their star formation properties, including age distribution, dynamical timescales, star formation rates, and galactic bar influence. We find a clear relationship between the position angles and ellipticities of the rings and those of their host galaxies, which indicates the rings are in the same plane as the disk and circular. We use population synthesis models to estimate ages of each H-alpha emitting HII region, which range from 1 Myr to 10 Myrs throughout the rings. We find that approximately half of the rings contain azimuthal age gradients that encompass at least 25% of the ring, although there is no apparent relationship between the presence or absence of age gradients and the morphology of the rings or their host galaxies. NGC1343, NGC1530, and NGC4321 show clear bipolar age gradients, where the youngest HII regions are located near the two contact points of the bar and ring. We speculate in these cases that the gradients are related to an increased mass inflow rate and/or an overall higher gas density in the ring, which would allow for massive star formation to occur on short timescales, after which the galactic rotation would transport the HII regions around the ring as they age. Two-thirds of the barred galaxies show correlation between the locations of the youngest HII region(s) in the ring and the location of the contact points, which is consistent with predictions from numerical modeling.Comment: 23 pages, 10 figures (7 color), 23 tables, accepted for publication in ApJS (Feb 08); NASA-GSFC, IAC, University of Maryland, STSc

Mid-sagittal plane detection for advanced physiological measurements in brain scans

Objective: The process of diagnosing many neurodegenerative diseases, such as Parkinson's and progressive supranuclear palsy, involves the study of brain magnetic resonance imaging (MRI) scans in order to identify and locate morphological markers that can highlight the health status of the subject. A fundamental step in the pre-processing and analysis of MRI scans is the identification of the mid-sagittal plane, which corresponds to the mid-brain and allows a coordinate reference system for the whole MRI scan set. Approach: To improve the identification of the mid-sagittal plane we have developed an algorithm in Matlab® based on the k-means clustering function. The results have been compared with the evaluation of four experts who manually identified the mid-sagittal plane and whose performances have been combined with a cognitive decisional algorithm in order to define a gold standard. Main results: The comparison provided a mean percentage error of 1.84%. To further refine the automatic procedure we trained a machine learning system using the results from the proposed algorithm and the gold standard. We tested this machine learning system and obtained results comparable to medical raters with a mean absolute error of 1.86 slices. Significance: The system is promising and could be directly incorporated into broader diagnostic support systems

Crizotinib plus radiotherapy in brain oligoprogressive NSCLC ROS1 rearranged and PD-L1 strong

ROS1+ patients represent a unique molecular subset of non-small cell lung cancer (NSCLC). Early phase clinical trials have shown a high response rate to crizotinib in these patients. We describe a case of an 18 years old woman, never smoker, with NSCLC ROS1+ and miliary brain metastases treated with crizotinib and radiotherapy. From October 2014 to June 2015 the Patient was treated with crizotinib. The first intracranial time to progression (IT-TTP) occurred after 7 months; the patient underwent stereotactic radiosurgery (SRS) and continued TKI treatment. The second IT-TTP appeared after 16 months. A continued response in the chest was observed for all the 23 months of crizotinib treatment. At the progression, we assessed programmed death ligand 1 (PD-L1) expression by immunohistochemistry, that resulted highly expressed. Our report indicates that the integration of crizotinib with local treatments should be considered in ROS1 NSCLC patients experiencing oligometastatic progression. Moreover, this case is an example of PD-L1 strong in oncogene addicted patients

A Young Stellar Cluster in the Nucleus of NGC 4449

We have obtained 1-2 A resolution optical Echellette spectra of the nuclear star cluster in the nearby starburst galaxy NGC 4449. The light is clearly dominated by a very young (6-10 Myr) population of stars. For our age dating, we have used recent population synthesis models to interpret the observed equivalent width of stellar absorption features such as the HI Balmer series and the CaII triplet around 8500 A. We also compare the observed spectrum of the nuclear cluster to synthesized spectra of simple stellar populations of varying ages. All these approaches yield a consistent cluster age. Metallicity estimates based on the relative intensities of various ionization lines yield no evidence for significant enrichment in the center of this low mass galaxy: the metallicity of the nuclear cluster is about one fourth of the solar value, in agreement with independent estimates for the disk material of NGC 4449.Comment: 24 pages (incl. 7 figures), accepted by AJ, March 2001 issue revised version with minor changes and additions, one additional figur

Gellan hydrogel as a powerful tool in paper cleaning process: a detailed study

Hypothesis: Wet cleaning of ancient papers is one of the most critical steps during a conservation treatment. It is used to improve the optical qualities of a graphic work and remove dust and by-products resulting from cellulose degradation. Nevertheless, washing treatment usually involves a substantial impact on the original morphological structure of paper and can sometimes be dangerous for water sensitive inks and pigments. Experiments: The use of rigid hydrogel of Gellan gum as an alternative paper cleaning treatment is developed. The application of a rigid hydrogel minimizes damages caused by the use of water, and therefore is much more respectful for the original integrity of ancient paper. Findings: Gellan hydrogel has been used to clean paper samples belonging to different centuries (from XVI to XIX) and therefore, characterized by a different story in terms of degradation condition and paper composition. Several techniques, such as high-performance liquid chromatography, Fourier transform infrared spectroscopy, scanning electron microscopy and pH measurements, has been employed to assess the effectiveness and safety of the proposed cleaning method