Distribución por tamaños de la materia particulada en Las Palmas de Gran Canaria

En este trabajo se presenta la distribución por tamaños de la materia particulada (MP)en la ciudad de Las Palmas de Gran Canaria. La experiencia se llevó a cabo entre junio de 2002 y marzo de 2003. A tal efecto se han utilizado captadores de alto volumen equipados con impactadores en cascada, que permiten una separación, en filtros de fibra de vidrio, de la materia recogida en seis fracciones de tamaño. Al final del muestreo se dispuso de 42 muestras válidas para el análisis. La materia particulada se determinó gravimétricamente. Se establecióla distribución de la concentración másica en función de los diámetros de corte. Se utilizan los diagramas de Lundgreen para establecer la distribución por tamaños y la evolución estacional e histórica. Se estudian las fracciones fina y gruesa del aerosol así como su evolución temporal e histórica

Relación entre dieta mediterránea, actividad física e índice de masa corporal en adolescentes de secundaria de dos pueblos de Granada

The objetive was evaluate the Adherence to Mediterranean Diet (AMD) in adolescents and the relationship with the Body Mass Index (BMI) and Physical Activity (PA). he study was realized with 209 adolescents (117 girls y 92 boys), between 12 and 18 years. he AMD was analysed through the KIDMED test and PA level was estimated using the International Physical Activity Questionnaire (IPAQ short version. he height and weigth was measured of each gymnastics, calculating BMI. he 65,6%, of the total sample showed an optimal AMD with a BMI of 20.02 kg/m2 without sex diferences. However, the boys showed signiicantly bigger physical activity level than girls. No signiicant relationships were found between variables MD, PA, BMI and gender. he habits of the Spanish adolescents in the sample are healthy, presenting the most optimal AMD, normal values of BMI and in good level of PA.El objetivo fue evaluar la Adherencia a la Dieta Mediterránea (ADM) en adolescentes y su relación con el Índice de Masa Corporal (IMC) y Actividad Física (AF). Participaron 209 estudiantes (117 chicas y 92 chicos) entre 12 y 18 años. Se analizó la ADM a través del test KIDMED y el grado de AF se estimó mediante el Cuestionario Internacional de Actividad Física. Se midió la altura y el peso de cada adolescente, calculándose el IMC. El 65,6%, de la muestra total, mostró una óptima ADM con un IMC de 20,02 kg/m2 sin diferencias de sexos. Sin embargo, los chicos mostraron mayor nivel de AF que las chicas, con diferencias estadísticamente significativas. No se encontraron relaciones signiicativas entre las variables DM, AF, IMC y género. Los hábitos de los adolescentes españoles de la muestra son saludables, presentando la mayoría óptima ADM, valores normales del IMC y buen nivel de AF

Quality of movement in Acrobatic Gymnastics teenagers and non-practitioners using the Funtional Movement Screen battery

Objetivo: Valorar la calidad de movimiento aplicando el Functional Movement Screen (FMS) en adolescentes de 12 a 17 años practicantes o no de Gimnasia Acrobática (GA). Método: Estudio descriptivo, comparativo y transversal donde participaron 41 adolescentes (20 practicantes de GA y 21 no practicantes). Se usó la batería FMS, compuesta por siete pruebas: sentadilla profunda, paso de valla, estocada en línea, movilidad de hombro, elevación activa de la pierna recta, estabilidad del tronco en flexiones, estabilidad rotatoria del tronco. Resultados: se observó una relación estadísticamente significativa de signo positivo a través del estadístico R de Spearman, entre la puntuación global del FMS y la práctica de GA (p= .023). Las gimnastas presentan mejor calidad de movimiento que las no practicantes, con diferencias estadísticamente significativas, puntuando mejor en prácticamente todas las pruebas. Conclusión: se corrobora una relación entre la práctica de GA y una mayor puntuación del FMS.Objective: To assess the quality of movement by applying the Functional Movement Screen (FMS) to teenagers aged 12 to 17, whether or not they practice Acrobatic Gymnastics (AG). Methods: Descriptive, comparative and crosssectional study in which 41 teenagers (20 AG practitioners and 21 non-practitioners) participated. The FMS battery was used, consisting of seven tests: deep squat, fence step, line lunge, shoulder mobility, active straight leg lift, trunk stability in bending, trunk rotation stability. Results: a statistically significant positive relationship was observed through Spearman’s R statistic, between the overall FMS score and the AG practice (p= .023). Gymnasts presented better quality of movement than nongymnastics practitioners, with statistically significant differences, scoring better in practically all tests. Conclusion: a relationship between AG practice and a higher FMS score is corroborated

Melatonin Enhances Cisplatin and Radiation Cytotoxicity in Head and Neck Squamous Cell Carcinoma by Stimulating Mitochondrial ROS Generation, Apoptosis, and Autophagy

Head and neck cancer is the sixth leading cancer by incidence worldwide. Unfortunately, drug resistance and relapse are the principal limitations of clinical oncology for many patients, and the failure of conventional treatments is an extremely demoralizing experience. It is therefore crucial to find new therapeutic targets and drugs to enhance the cytotoxic effects of conventional treatments without potentiating or offsetting the adverse effects. Melatonin has oncostatic effects, although the mechanisms involved and doses required remain unclear. The purpose of this study is to determine the precise underlying mitochondrial mechanisms of melatonin, which increase the cytotoxicity of oncological treatments, and also to propose new melatonin treatments in order to alleviate and reverse radio- and chemoresistant processes. We analyzed the effects of melatonin on head and neck squamous cell carcinoma (HNSCC) cell lines (Cal-27 and SCC-9), which were treated with 0.1, 0.5, 1, and 1.5mM melatonin combined with 8 Gy irradiation or 10 μM cisplatin. Clonogenic and MTT assays, as well as autophagy and apoptosis, involving flow cytometry and western blot, were performed in order to determine the cytotoxic effects of the treatments. Mitochondrial function was evaluated by measuring mitochondrial respiration, mtDNA content (RT-PCR), and mitochondrial mass (NAO). ROS production, antioxidant enzyme activity, and GSH/GSSG levels were analyzed using a fluorometric method. We show that high concentrations of melatonin potentiate the cytotoxic effects of radiotherapy and CDDP in HNSCC, which are associated with increased mitochondrial function in these cells. In HNSCC, melatonin induces intracellular ROS, whose accumulation plays an upstream role in mitochondria-mediated apoptosis and autophagy. Our findings indicate that melatonin, at high concentrations, combined with cisplatin and radiotherapy to improve its effectiveness, is a potential adjuvant agent.This study was partially supported by grants from the Ministerio de Economía y Competitividad, Spain, and the FEDER Regional Development Fund (nos. SAF2013-49019 and SAF2017-85903), from the Instituto de Salud Carlos III (no. CB/10/00238), and from the Consejería de Economía, Innovación, Ciencia y Empleo, Junta de Andalucía (CTS-101)

El papel de los estudios bioarqueológicos en las interpretaciones sobre las comunidades neolíticas del noreste peninsular

Resumen del trabajo presentado al VI Congreso del Neolítico en la Península Ibérica: "Los cambios económicos y sus implicaciones sociales durante el Neolítico de la Península Ibérica", celebrado en Granada del 22 al 26 de junio de 2016.-- et al.El marco del proyecto I+D: “Aproximación a las primeras comunidades neolíticas del NE peninsular a través de sus prácticas funerarias” (2011-2015), y su continuidad para los próximos cuatro años al haber sido renovado, tiene por objetivo conocer cada día más y mejor las comunidades de agricultores y pastores que entre finales del V e inicios del IV milenio cal BC ocuparon y enterraron a sus muertos en el noreste de la Península Ibérica. El contexto de estudio es excepcional, puesto que aquellas comunidades inhumaron sistemáticamente a sus congéneres en tumbas habitualmente individuales y ocasionalmente junto a otro individuo. En esta presentación no sólo queremos mostrar los nuevos análisis y metodologías que estamos aplicando al estudio de los restos humanos, sino también el modelo de trabajo que hemos seguido. A este respecto, tres aspectos son fundamentales: 1) las dataciones absolutas son el eje que vertebra los posteriores análisis; 2) la colaboración con los distintos investigadores/as y laboratorios debe ser estrecha (no es cuestión de solicitar los resultados de un análisis a un laboratorio sino trabajar con las personas que manipulan las muestras y conocen los pros y contras de cada una de las técnicas empleadas) y 3) los estudios y análisis a realizar confluyen para responder a las hipótesis planteadas. A este respecto, en el proyecto hemos tenido la fortuna de poder colaborar con numerosos investigadores/as cuya especialidad versa alrededor de los restos funerarios y que firman la presente comunicación: análisis isotópicos, Adn, tafonomía funeraria, estudios de stress muscular y análisis de morfología dental.Peer Reviewe

Magma emission rates fromshallow submarine eruptions using airborne thermal imaging

The effusion rate is the most important parameter to gatherwhen a volcanic eruption occurs, because it controls the way inwhich a lava body grows, extends and expands, influencing its dimensional properties. Calculation of lava flow volume from thermal images collected by helicopter surveys has been largely used during the last decade for monitoring subaerial effusive eruptions. However, due to the depths where volcanic activity occurs, monitoring submarine volcanic eruptions is a very difficult task. The 2011–2012 submarine volcanic eruption at El Hierro, Canary Islands, has provided a unique and excellent opportunity to monitor eruptive processes occurring on the seabed. The use of a hand-held thermal camera during daily helicopter flights allowed us to estimate for the first time the daily and total erupted magma volumes from a submarine eruption. The volume of magma emitted during this eruption has been estimated at 300 Mm3, giving an average effusion rate of ~25 m3 s−1. Thermal imagery by helicopter proved to be a fast, inexpensive, safe and reliable technique of monitoring volcanic eruptions when they occur on the shallow seabed.This research was financially supported by the projects MAKAVOL (MAC/3/C161) from the European Union MAC 2007–2013 Transnational Cooperation Program as well as from the Cabildo Insular de Tenerife. We are also grateful to the staff of El Hierro airport (AENA) for providing logistical support.Published219-2255V. Sorveglianza vulcanica ed emergenzeJCR Journalrestricte

Privacy-preserving machine learning with tensor networks

Tensor networks, widely used for providing efficient representations of low-energy states of local quantum many-body systems, have been recently proposed as machine learning architectures which could present advantages with respect to traditional ones. In this work we show that tensor-network architectures have especially prospective properties for privacy-preserving machine learning, which is important in tasks such as the processing of medical records. First, we describe a new privacy vulnerability that is present in feedforward neural networks, illustrating it in synthetic and real-world datasets. Then, we develop well-defined conditions to guarantee robustness to such vulnerability, which involve the characterization of models equivalent under gauge symmetry. We rigorously prove that such conditions are satisfied by tensor-network architectures. In doing so, we define a novel canonical form for matrix product states, which has a high degree of regularity and fixes the residual gauge that is left in the canonical forms based on singular value decompositions. We supplement the analytical findings with practical examples where matrix product states are trained on datasets of medical records, which show large reductions on the probability of an attacker extracting information about the training dataset from the model's parameters. Given the growing expertise in training tensor-network architectures, these results imply that one may not have to be forced to make a choice between accuracy in prediction and ensuring the privacy of the information processed

Comment on "Evidence from acoustic imaging for submarine volcanic activity in 2012 off the west coast of El Hierro (Canary Islands, Spain)" by Pérez NM, Somoza L, Hernández PA, González de Vallejo L, León R, Sagiya T, Biain A, González FJ, Medialdea T, Barrancos J, Ibáñez J, Sumino H, Nogami K and Romero C [Bull Volcanol (2014) 76:882-896]

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Derivation and external validation of the SIMPLICITY score as a simple immune-based risk score to predict infection in kidney transplant recipients

Existing approaches for infection risk stratification in kidney transplant recipients are suboptimal. Here, we aimed to develop and validate a weighted score integrating non-pathogen-specific immune parameters and clinical variables to predict the occurrence of post-transplant infectious complications. To this end, we retrospectively analyzed a single-center derivation cohort of 410 patients undergoing kidney transplantation in 2008-2013 in Madrid. Peripheral blood lymphocyte subpopulations, serum immunoglobulin and complement levels were measured at one-month post-transplant. The primary and secondary outcomes were overall and bacterial infection through month six. A point score was derived from a logistic regression model and prospectively applied on a validation cohort of 522 patients undergoing kidney transplantation at 16 centers throughout Spain in 2014-2015. The SIMPLICITY score consisted of the following variables measured at month one after transplantation: C3 level, CD4+ T-cell count, CD8+ T-cell count, IgG level, glomerular filtration rate, recipient age, and infection within the first month. The discrimination capacity in the derivation and validation cohorts was good for overall (areas under the receiver operating curve of 0.774 and 0.730) and bacterial infection (0.767 and 0.734, respectively). The cumulative incidence of overall infection significantly increased across risk categories in the derivation (low-risk 13.7%; intermediate-risk, 35.9%; high-risk 77.6%) and validation datasets (10.2%, 28.9% and 50.4%, respectively). Thus, the SIMPLICITY score, based on easily available immune parameters, allows for stratification of kidney transplant recipients at month one according to their expected risk of subsequent infection