Erythrocytes in multiple sclerosis: forgotten contributors to the pathophysiology?

Multiple sclerosis (MS) is an autoimmune disease characterised by lymphocytic infiltration of the central nervous system and subsequent destruction of myelin and axons. On the background of a genetic predisposition to autoimmunity, environmental triggers are assumed to initiate the disease. The majority of MS research has focused on the pathological involvement of lymphocytes and other immune cells, yet a paucity of attention has been given to erythrocytes, which may play an important role in MS pathology. The following review briefly summarises how erythrocytes may contribute to MS pathology through impaired antioxidant capacity and altered haemorheological features. The effect of disease-modifying therapies on erythrocytes is also reviewed. It may be important to further investigate erythrocytes in MS, as this could broaden the understanding of the pathological mechanisms of the disease, as well as potentially lead to the discovery of novel and innovative targets for future therapies

Deformations of quantum field theories on de Sitter spacetime

Quantum field theories on de Sitter spacetime with global U(1) gauge symmetry are deformed using the joint action of the internal symmetry group and a one-parameter group of boosts. The resulting theory turns out to be wedge-local and non-isomorphic to the initial one for a class of theories, including the free charged Dirac field. The properties of deformed models coming from inclusions of CAR-algebras are studied in detail.Comment: 26 pages, no figure

Quantization of the Chern-Simons Coupling Constant

We investigate the quantum consistency of p-form Maxwell-Chern-Simons electrodynamics in 3p+2 spacetime dimensions (for p odd). These are the dimensions where the Chern--Simons term is cubic, i.e., of the form FFA. For the theory to be consistent at the quantum level in the presence of magnetic and electric sources, we find that the Chern--Simons coupling constant must be quantized. We compare our results with the bosonic sector of eleven dimensional supergravity and find that the Chern--Simons coupling constant in that case takes its corresponding minimal allowed value.Comment: 15 pages, 1 figure, JHEP3.cls. Equation (8.6) corrected and perfect agreement with previous results is obtaine

NS5-branes in IIA supergravity and gravitational anomalies

We construct a gravitational-anomaly-free effective action for the coupled system of IIA D=10 dynamical supergravity interacting with an NS5-brane. The NS5-brane is considered as elementary in that the associated current is a delta-function supported on its worldvolume. Our approach is based on a Chern-kernel which encodes the singularities of the three-form field strength near the brane in an SO(4)-invariant way and provides a solution for its Bianchi identity in terms of a two-form potential. A dimensional reduction of the recently constructed anomaly-free effective action for an elementary M5-brane in D=11 is seen to reproduce our ten-dimensional action. The Chern-kernel approach provides in particular a concrete realization of the anomaly cancellation mechanism envisaged by Witten.Comment: LaTex, 31 pages, no figure

Scaling limits of integrable quantum field theories

Short distance scaling limits of a class of integrable models on two-dimensional Minkowski space are considered in the algebraic framework of quantum field theory. Making use of the wedge-local quantum fields generating these models, it is shown that massless scaling limit theories exist, and decompose into (twisted) tensor products of chiral, translation-dilation covariant field theories. On the subspace which is generated from the vacuum by the observables localized in finite light ray intervals, this symmetry can be extended to the M\"obius group. The structure of the interval-localized algebras in the chiral models is discussed in two explicit examples.Comment: Revised version: erased typos, improved formulations, and corrections of Lemma 4.8/Prop. 4.9. As published in RMP. 43 pages, 1 figur

rf-electrometer using a carbon nanotube resonant tunneling transistor

We have studied resonant tunneling transistors (RTT) made of single-walled carbon nanotube quantum dots in the Fabry–Pérot regime. We show sensitivity to input charge as high as 5×10 exp −6 e/Hz1/2 with a carrier frequency of 719 MHz at 4.2 K. This result is comparable to the best values of charge sensitivity so far reported for radio frequency single electron transistors (rf-SET). Unlike SETs, whose operating temperature is limited as Coulomb blockade vanishes as 1/T, a RTT can operate at higher temperatures, since the dephasing length lϕ∝1/T exp 2/exp 3.Peer reviewe

Nonequilibrium candidate Monte Carlo: A new tool for efficient equilibrium simulation

Metropolis Monte Carlo simulation is a powerful tool for studying the equilibrium properties of matter. In complex condensed-phase systems, however, it is difficult to design Monte Carlo moves with high acceptance probabilities that also rapidly sample uncorrelated configurations. Here, we introduce a new class of moves based on nonequilibrium dynamics: candidate configurations are generated through a finite-time process in which a system is actively driven out of equilibrium, and accepted with criteria that preserve the equilibrium distribution. The acceptance rule is similar to the Metropolis acceptance probability, but related to the nonequilibrium work rather than the instantaneous energy difference. Our method is applicable to sampling from both a single thermodynamic state or a mixture of thermodynamic states, and allows both coordinates and thermodynamic parameters to be driven in nonequilibrium proposals. While generating finite-time switching trajectories incurs an additional cost, driving some degrees of freedom while allowing others to evolve naturally can lead to large enhancements in acceptance probabilities, greatly reducing structural correlation times. Using nonequilibrium driven processes vastly expands the repertoire of useful Monte Carlo proposals in simulations of dense solvated systems

Impedance measurements and simulations on the TCT and TDI LHC collimators

The LHC collimation system is a critical element for the safe operation of the LHC machine and it is subject to continuous performance monitoring, hardware upgrade and optimization. In this work we will address the impact on impedance of the upgrades performed on the injection protection target dump (TDI), where the absorber material has been changed to mitigate the device heating observed in machine operation, and on selected secondary (TCS) and tertiary (TCT) collimators, where beam position monitors (BPM) have been embedded for faster jaw alignment. Con- cerning the TDI, we will present the RF measurements per- formed before and after the upgrade, comparing the result to heating and tune shift beam measurements. For the TCTs, we will study how the higher order modes (HOM) intro- duced by the BPM addition have been cured by means of ferrite placement in the device. The impedance mitigation campaign has been supported by RF measurements whose results are in good agreement with GdfidL and CST simula- tions. The presence of undamped low frequency modes is proved not to be detrimental to the safe LHC operation