245 research outputs found
Convex domains of Finsler and Riemannian manifolds
A detailed study of the notions of convexity for a hypersurface in a Finsler
manifold is carried out. In particular, the infinitesimal and local notions of
convexity are shown to be equivalent. Our approach differs from Bishop's one in
his classical result (Bishop, Indiana Univ Math J 24:169-172, 1974) for the
Riemannian case. Ours not only can be extended to the Finsler setting but it
also reduces the typical requirements of differentiability for the metric and
it yields consequences on the multiplicity of connecting geodesics in the
convex domain defined by the hypersurface.Comment: 22 pages, AMSLaTex. Typos corrected, references update
Infinitesimal and local convexity of a hypersurface in a semi-Riemannian manifold
Given a Riemannian manifold M and a hypersurface H in M, it is well known
that infinitesimal convexity on a neighborhood of a point in H implies local
convexity. We show in this note that the same result holds in a semi-Riemannian
manifold. We make some remarks for the case when only timelike, null or
spacelike geodesics are involved. The notion of geometric convexity is also
reviewed and some applications to geodesic connectedness of an open subset of a
Lorentzian manifold are given.Comment: 14 pages, AMSLaTex, 2 figures. v2: typos fixed, added one reference
and several comments, statement of last proposition correcte
Clonal spread of a unique strain of macrolide-resistant mycoplasma pneumoniae within a single family in Italy
Macrolide-resistant Mycoplasma pneumoniae (MR-MP) is an increasing problem worldwide. This study describes the clonal spread of a unique strain of MR-MP within a single family. On January 23, 2015, nasopharyngeal swabs and sputum samples were collected from the index case (a 9-year-old girl) in southern Italy. The patient had pneumonia and was initially treated with clarithromycin. MR-MP infection was suspected due to prolonged symptoms despite appropriate antibiotic therapy. Two further cases of pneumonia occurred in relatives (a 7-year-old cousin and the 36-year-old mother of the index case); therefore, respiratory samples were also collected from other family members. Sequence analysis identified mutations associated with resistance to macrolides. Both P1 major adhesion protein typing and multiple loci variable-number tandem repeat analysis (MLVA) typing were performed to assess the relatedness of the strains. The index case, the cousin, the mother, and another 4 family members (twin siblings of the index case, a 3-year-old cousin, and the grandmother) were positive for MR-MP. All strains harbored the mutation A2063G, had the same P1 subtype (1), and were MLVA (7/4/5/7/2) type Z. In addition, the index case's aunt (31 years of age and the probable source of infection) harbored an M pneumoniae strain with the same molecular profile; however, this strain was susceptible to macrolides. This cluster of MR-MP infection/carriage caused by a clonal strain suggests a high transmission rate within this family and highlights the need for increased awareness among clinicians regarding the circulation of MR-MP. Novel strategies for the treatment and prevention of M pneumoniae infections are required
On the energy functional on Finsler manifolds and applications to stationary spacetimes
In this paper we first study some global properties of the energy functional
on a non-reversible Finsler manifold. In particular we present a fully detailed
proof of the Palais--Smale condition under the completeness of the Finsler
metric. Moreover we define a Finsler metric of Randers type, which we call
Fermat metric, associated to a conformally standard stationary spacetime. We
shall study the influence of the Fermat metric on the causal properties of the
spacetime, mainly the global hyperbolicity. Moreover we study the relations
between the energy functional of the Fermat metric and the Fermat principle for
the light rays in the spacetime. This allows us to obtain existence and
multiplicity results for light rays, using the Finsler theory. Finally the case
of timelike geodesics with fixed energy is considered.Comment: 23 pages, AMSLaTeX. v4 matches the published versio
Frequency of human papillomavirus infection and genotype distribution among women with known cytological diagnosis in a Southern Italian region
Introduction. In the Puglia region (South Italy) about 200 new hospitalizations for cervical cancer are registered every year. The study investigated the frequency of Human Papillomavirus
(HPV) infection and the genotype distribution of HPV in a sample of women with known cytology attending the outpatient clinics of four Gynecological Departments of the University of Bari over a four-year period (2005-2008).
Methods. Cervical samples from 1,168 women were analyzed for the presence of HPV-DNA through Polymerase Chain Reaction (PCR) in L1 region and reverse hybridization. The cytological results were associated with HPV positivity and type-specific prevalence.
Results. Overall, HPV infection was found in 355 (30.4%) women. HPV-DNA was found in 34.4% of women with a cytological diagnosis of ASCUS, in 46.8% of women with Low-grade Squamous Intraepithelial Lesion (LSIL) and in 87.0% of women with High-grade Squamous Intraepithelial Lesion (HSIL)/carcinoma. Also 16.0% of women with normal Pap smear were found to be HPV-DNA positive. The most common HPV genotype was type 16 found in 27.3% of positives, followed by type 53 (11.5%), type 66 (9.2%) and type 31 (9.0%). HPV genotype 18 was found in 6.4% of positives. Types 16 or 18 were detected in about 34% (120/355) of all infected women, in about 33% of LSIL and in 60% of HSIL/ carcinoma HPV-positive women. Among low risk (LR) genotypes, type 61 was found in 10.7% of HPV positive women, type 62 in 8.4%, type 42 in 8.1% and type CP6108 in 7.8%.
Discussion and conclusions. The findings of the study give evidence that HPV infection is frequent in the studied cohort of women. The most widespread genotypes found were 16 and 53.
These data may represent a benchmark for future evaluation after the recent introduction of vaccination against HPV in 12-year-old girls
Nuclear Stopping in Au+Au Collisions at sqrt(sNN) = 200 GeV
Transverse momentum spectra and rapidity densities, dN/dy, of protons,
anti-protons, and net--protons (p-pbar) from central (0-5%) Au+Au collisions at
sqrt(sNN) = 200 GeV were measured with the BRAHMS experiment within the
rapidity range 0 < y < 3. The proton and anti-proton dN/dy decrease from
mid-rapidity to y=3. The net-proton yield is roughly constant for y<1 at
dN/dy~7, and increases to dN/dy~12 at y~3. The data show that collisions at
this energy exhibit a high degree of transparency and that the linear scaling
of rapidity loss with rapidity observed at lower energies is broken. The energy
loss per participant nucleon is estimated to be 73 +- 6 GeV.Comment: 5 pages, 4 figure
Evolution of the nuclear modification factors with rapidity and centrality in d+Au collisions at $\sqrt{s_{NN}} = 200 GeV
We report on a study of the transverse momentum dependence of nuclear
modification factors for charged hadrons produced in deuteron + gold
collisions at GeV, as a function of collision centrality
and of the pseudorapidity () of the produced hadrons. We
find significant and systematic decrease of with increasing rapidity.
The midrapidity enhancement and the forward rapidity suppression are more
pronounced in central collisions relative to peripheral collisions. These
results are relevant to the study of the possible onset of gluon saturation at
RHIC energies.Comment: Four pages, four figures. Published in PRL. Figures 1 and 2 have been
updated, and several changes made to the tex
Recent Results from the BRAHMS Experiment
We present recent results obtained by the BRAHMS experiment at the
Relativistic Heavy Ion Collider (RHIC) for the systems of Au + Au and Cu + Cu
at \rootsnn{200} and at 62.4 GeV, and p + p at \rootsnn{200}. Nuclear
modification factors for Au + Au and Cu + Cu collisions are presented. Analysis
of anti-particle to particle ratios as a function of rapidity and collision
energy reveal that particle populations at the chemical freeze-out stage for
heavy-ion reactions at and above SPS energies are controlled by the baryon
chemical potential. From the particle spectra we deduce significant radial
expansion ( 0.75), as expected for systems created with a large
initial energy density. We also measure the elliptic flow parameter
versus rapidity and \ptn. We present rapidity dependent ratios within
for Au + Au and Cu + Cu at \rootsnn{200}. \Raa is found to increase
with decreasing collision energy, decreasing system size, and when going
towards more peripheral collisions. However, \Raa shows only a very weak
dependence on rapidity (for ), both for pions and protons.Comment: 16 pages and 14 figures, proceedings for plenary talk at Quark Matter
2005, Budapest, Hungar
Centrality dependence of charged-particle pseudorapidity distributions from d+Au collisions at sqrt(s_{NN})=200 GeV
Charged-particle pseudorapidity densities are presented for the d+Au reaction
at sqrt{s_{NN}}=200 GeV with -4.2 <= eta <= 4.2$. The results, from the BRAHMS
experiment at RHIC, are shown for minimum-bias events and 0-30%, 30-60%, and
60-80% centrality classes. Models incorporating both soft physics and hard,
perturbative QCD-based scattering physics agree well with the experimental
results. The data do not support predictions based on strong-coupling,
semi-classical QCD. In the deuteron-fragmentation region the central 200 GeV
data show behavior similar to full-overlap d+Au results at sqrt{s_{NN}}=19.4
GeV.Comment: 4 pages, 3figures; expanded discussion of uncertainties; added 60-80%
centrality range; added additional discussion on centrality selection bia
Scanning the phases of QCD with BRAHMS
BRAHMS has the ability to study relativistic heavy ion collisions from the
final freeze-out of hadrons all the way back to the initial wave-function of
the gold nuclei. This is accomplished by studying hadrons with a very wide
range of momenta and angles. In doing so we can scan various phases of QCD,
from a hadron gas, to a quark gluon plasma and perhaps to a color glass
condensate.Comment: 8 pages, 6 figures, proceedings of plenary talk at Quark Matter 2004
conferenc
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