Die behoefte aan dinamiese tersiêre Geskiedeniskurrikula tot voordeel van mededissiplines en gunstiger beroepsmoontlikhede

The study of History in South Africa demands high standards in the rapidlychanging late twentieth century. Standards require reform and change in research themes, in methodology and in the instruction of the discipline. During the seventies and eighties the practice of History has already been characterized by much reform. For example, some aspects of curricula on tertiary level changed from a purely chronological approach and began to lean towards the inclusion of innovative and contemporary relevant themes of periods perceived as significant. Presently, however, commentators from other disciplines still think of History as a subject dealing only with endless facts embedded in past politics. The mam reason for this distorted image is probably that the trend of reconstructing History curricula is not being sufficiently explored or marketed at the tertiary level. This emphasises the task of the historian to adapt curricula dynamically in order to enhance other disciplines to their benefit. Adaptation will have the added advantage of improving employment for graduates with a training in History. In this article the dynamic change which tertiary History curricula should adopt in order to improve disciplinary curricular interaction and favourable employment opportunities is discussed

Incidence, prevalence and mortality of anorexia nervosa and bulimia nervosa

To review the recent literature on the epidemiology of anorexia nervosa and bulimia nervosa in terms of incidence, prevalence and mortality. RECENT FINDINGS: Although the overall incidence rate of anorexia nervosa is considerably stable over the past decades, the incidence among younger persons (aged <15 years) has increased. It is unclear whether this reflects earlier detection or earlier age of onset. Nevertheless, it has implications for future research into risk factors and for prevention programs. For bulimia nervosa, there has been a decline in overall incidence rate over time. The lifetime prevalence rates of anorexia nervosa might be up to 4% among females and 0.3% among males. Regarding bulimia nervosa, up to 3% of females and more than 1% of males suffer from this disorder during their lifetime. While epidemiological studies in the past mainly focused on young females from Western countries, anorexia nervosa and bulimia nervosa are reported worldwide among males and females from all ages. Both eating disorders may carry a five or more times increased mortality risk. SUMMARY: Anorexia nervosa and bulimia nervosa occur worldwide among females and males of all age groups and are associated with an increased mortality risk

A study of the relationship between health awareness, lifestyle behaviour and food label usage in Gauteng

Background: The objectives of the study were to determine whether consumers who read food labels, were also more aware of health and lifestyle issues, in terms of nutrition and other health-related lifestyle behaviours, and whether there was a relationship between food-label reading, health awareness and lifestyle behaviour. A quantitative descriptive (survey) design was selected to investigate the relationship between food-label reading on the one hand, and health awareness and lifestyle behavior on the other.Method: A two-stage, stratified-proportionate and systematic sampling strategy was applied to select a sample of 357 Gauteng respondents to complete a telephonic questionnaire. Respondents who were most likely to read food label information were selected. Food label information is prescribed by comprehensive label legislation. Data report on respondents&rsquo; label-reading habits, attitudes towards health awareness, lifestyle behaviour and biographic data. Nonparametric analysis, scale reliability tests, analysis of variance (ANOVA) and Bonferroni multiple comparisons of means tests were used to analyse the results.Results: Results indicate that the two-thirds of respondents who, to some extent read nutritional information on food labels, were concerned about their personal health, were interested in health-related information, and followed a healthy lifestyle, such as regularly eating fresh fruit and vegetables, cutting back on alcohol, and other positive lifestyle behaviours. They were unsure about how their own knowledge of nutrition,and their understanding of nutrition information on food labels, compared with that of other consumers.Conclusion: A relationship was found between patterns of reading food labels, health awareness and lifestyle behaviour. People who often read food labels were more health-conscious, and maintained a healthier lifestyle.Keywords: health awareness, lifestyle, food labels, South Africa, consumer

The essence of water services management according to surface water catchment regions: A case study of Delmas Local Municipality

The nature and extent of local governance regarding water services management in South Africa (SA) have been transformed since the proclamation of the Constitution of the Republic of South Africa, 1996, the National Water Act 36 of 1998 and the Local Government: Municipal Structures Act 117 of 1998. For the first time, the place and role of a developmentally orientated local government sphere have been clearly identified. Unfortunately, there are some serious challenges that the newly-merged municipalities must try to manage more effectively, efficiently, economically, equally and environmentally sensitively than their predecessors did. Aspects that come to mind include the need to incorporate a more holistic and integrated management approach to water services management according to the surface water catchment areas the Department of Water Affairs demarcated, to consider account the dangers of developing urban areas that are geologically underlain by dolomite rock, as well as the need to obtain, develop and retain the necessary experience, knowledge and skills capacity to manage the diverse and highly-complex basic services, such as the potable (drinking) water supply in a sustainable manner. This article will firstly highlight the changed environmental context of public service delivery in the local government sphere of the country. Hereafter, the focus will shift to the nature and extent of current realities of local governance. This includes the dynamics and challenges regarding a basic public service, such as potable water supply. Lastly, the nature and extent of water services management in, for example a municipality situated in a dolomite area (Delmas) will be explored. The article aims to contribute to the cultivation of an environment conducive to consolidating local governance and gaining knowledge of water management in the local government sphere.Public Administration and Managemen

Increase in incidence of anorexia nervosa among 10- to 14-year-old girls:A nationwide study in the Netherlands over four decades

Objective: This primary care study examined time trends in the incidence of anorexia nervosa (AN) and bulimia nervosa (BN) in the Netherlands across four decades. Methods: A nationwide network of general practitioners, serving approximately 1% of the total Dutch population, recorded newly diagnosed patients with AN and BN in their practices from 1985 to 2019 (2,890,978 person-years). DSM-IV diagnostic criteria were consistently used and the same psychiatrist was responsible for the final diagnostic decision. Incidence rates (IRs) were calculated for: the total population (all ages), females overall, and females per 5-year age category. Time trends in IRs were analyzed using JoinPoint regression analyses. Results: In four decades, the incidence of AN among 10- to 14-year-old females increased significantly from 8.6 to 38.6 per 100,000 person-years (average period percentage change [APPC] = 56.7; 95% confidence interval [CI] = 6.5–130.6. The overall incidence of AN was stable, with IRs ranging from 6.0 (95% CI = 4.3–8.1) to 8.4 (95% CI = 6.4–10.8). The IR of BN decreased significantly from 8.7 (95% CI = 6.7–11.0) to 3.2 (95% CI = 2.0–4.9) in the 2000s, before leveling off in the 2010s (IR 3.2; 95% CI = 2.0–4.8). Discussion: The incidence of AN among 10- to 14-year-old girls increased significantly over four decades. Both biological and sociocultural factors, for example, early pubertal timing and the impact of social media, might explain this. In other age groups and overall, the incidence of AN remained stable. The significant decrease of the incidence of BN in the previous decades halted in the last decade. Public Significance: An important finding of the present study is that for 10- to 14-year-old girls, the risk for developing anorexia nervosa has increased significantly over 40 years. More healthcare facilities for younger people are needed, and prevention programs could include social media use. For bulimia nervosa, the general decrease in the occurrence of new cases has halted in the 2010s.</p

A high throughput zebrafish chemical screen reveals ALK5 and non-canonical androgen signalling as modulators of the pkd2−/− phenotype

Autosomal dominant polycystic kidney disease (ADPKD) is the most common monogenic cause of end-stage renal failure in humans and results from germline mutations in PKD1 or PKD2. Despite the recent approval of tolvaptan, safer and more effective alternative drugs are clearly needed to slow disease progression. As a first step in drug discovery, we conducted an unbiased chemical screen on zebrafish pkd2 mutant embryos using two publicly available compound libraries (Spectrum, PKIS) totalling 2,367 compounds to identify novel treatments for ADPKD. Using dorsal tail curvature as the assay readout, three major chemical classes (steroids, coumarins, flavonoids) were identified from the Spectrum library as the most promising candidates to be tested on human PKD1 cystic cells. Amongst these were an androgen, 5α−androstane 3,17-dione, detected as the strongest enhancer of the pkd2 phenotype but whose effect was found to be independent of the canonical androgen receptor pathway. From the PKIS library, we identified several ALK5 kinase inhibitors as strong suppressors of the pkd2 tail phenotype and in vitro cyst expansion. In summary, our results identify ALK5 and non-canonical androgen receptors as potential therapeutic targets for further evaluation in drug development for ADPKD

The zebrafish mutants dre, uki, and lep encode negative regulators of the hedgehog signaling pathway.

Proliferation is one of the basic processes that control embryogenesis. To identify factors involved in the regulation of proliferation, we performed a zebrafish genetic screen in which we used proliferating cell nuclear antigen (PCNA) expression as a readout. Two mutants, hu418B and hu540A, show increased PCNA expression. Morphologically both mutants resembled the dre (dreumes), uki (ukkie), and lep (leprechaun) mutant class and both are shown to be additional uki alleles. Surprisingly, although an increased size is detected of multiple structures in these mutant embryos, adults become dwarfs. We show that these mutations disrupt repressors of the Hedgehog (Hh) signaling pathway. The dre, uki, and lep loci encode Su(fu) (suppressor of fused), Hip (Hedgehog interacting protein), and Ptc2 (Patched2) proteins, respectively. This class of mutants is therefore unique compared to previously described Hh mutants from zebrafish genetic screens, which mainly show loss of Hh signaling. Furthermore, su(fu) and ptc2 mutants have not been described in vertebrate model systems before. Inhibiting Hh activity by cyclopamine rescues uki and lep mutants and confirms the overactivation of the Hh signaling pathway in these mutants. Triple uki/dre/lep mutants show neither an additive increase in PCNA expression nor enhanced embryonic phenotypes, suggesting that other negative regulators, possibly Ptc1, prevent further activation of the Hh signaling pathway. The effects of increased Hh signaling resulting from the genetic alterations in the uki, dre, and lep mutants differ from phenotypes described as a result of Hh overexpression and therefore provide additional insight into the role of Hh signaling during vertebrate development

A psychological perspective on god-belief as a source of well-being and meaning

This article reports on a qualitative exploration of the well-being and meaning that second- and third-generation Christians from an African context experience because of their integration of religion in their life and being. A textured, integrated tapestry is created of the participants’ understanding of God (God-concept), experience of their relationship with God (God-image) and understanding of life as coloured by their belief systems. The contribution of their God-belief to their sense of meaning and psychological well-being frames the tapestry of this article.http://www.hts.org.zahb201