6 research outputs found
Loss of p53 in quaking viable mice leads to Purkinje cell defects and reduced survival
The qkv mutation is a one megabase deletion resulting in
abnormal expression of the qkI gene. qkv mice exhibit
hypomyelination of the central nervous system and display rapid tremors and seizures
as adults. The qkI locus on 6q26-27 has also been implicated as a candidate
tumor suppressor gene as the qkI locus maps to a region of genetic
instability in Glioblastoma Multiforme (GBM), an aggressive brain tumor of
astrocytic lineage. As GBM frequently harbors mutations affecting p53, we
crossbred qkv and p53 mutant mice to examine whether
qkv mice on a p53−/−
background have an increased incidence of GBM.
qkv/v;
p53−/− mice had a reduced survival rate
compared to p53−/− littermates, and the cause of
death of the majority of the mice remains unknown. In addition, immunohistochemistry
revealed Purkinje cell degeneration in the cerebellum. These results suggest that
p53 and qkI are genetically linked for neuronal maintenance and
survival
The QKI-6 RNA Binding Protein Regulates Actin-interacting Protein-1 mRNA Stability during Oligodendrocyte Differentiation
We identify new mRNA targets for the QKI-6 RNA binding proteins using an unbiased approach. We show that AIP-1 mRNA is bound by QKI-6 within its 3′-UTR. This regulation is observed in oligodendrocytes and it is essential for oligodendrocyte process outgrowth