Does the Wechsler Intelligence Scale for Children / 3rd edition discriminate between LD and non-LD children, ages 9 to 16 years old?

The primary purpose of this study was to determine whether the Wechsler’s Intelligence Scale for Children / 3rd Edition (WISC-III) can discriminate between students with learning disabilities (LD students) and students without learning disabilities (non-LD students). Although the WISC-III has established itself as a valuable psychological instrument for measuring intelligence, the subtests of the WISC-IH have been selected to examine possible differentiating patterns when examining a group of LD subjects and comparing their subtest results to a group of non-LD subjects. The current study proposes to examine the capability of the WISC-HI’s subtests to discriminate between a population of LD and Non-LD children, in West Virginia, ages 9 years to 16 years

Impact of in utero exposure to EtOH on corpus callosum development and paw preference in rats: protective effects of silymarin

BACKGROUND: Using a rat model we have found that the bioflavonoid silymarin (SY) ameliorates some of the negative consequences of in utero exposure to ethanol (EtOH). In the current study our aim was to determine if laterality preference and corpus callosum development were altered in rat offspring whose mothers were provided with a concomitant administration of SY with EtOH throughout gestation. METHODS: We provided pregnant Fisher/344 rats with liquid diets containing 35% ethanol derived calories (EDC) throughout the gestational period. A silymarin/phospholipid compound containing 29.8% silybin was co administered with EtOH to a separate experimental group. We tested the offspring for laterality preference at age 12 weeks. After testing the rats were sacrificed and their brains perfused for later corpus callosum extraction. RESULTS: We observed incomplete development of the splenium in the EtOH-only offspring. Callosal development was complete in all other treatment groups. Rats from the EtOH-only group displayed a left paw preference; whereas control rats were evenly divided between right and left paw preference. Inexplicably both SY groups were largely right paw preferring. CONCLUSIONS: The addition of SY to the EtOH liquid diet did confer some ameliorative effects upon the developing fetal rat brain