Post-Soviet studies: crisis of concepts, conventions, and compromises

The roundtable is a response to the state of distress in which many researchers of postSoviet processes, spaces, and transformations found themselves after the start of the war in Ukraine in February 2022. The nature of this anguish can be found, first of all, in the realization of the irreversibility of the events. But it also captured social scientists’ professional sphere. The crisis of post-Soviet studies, which had already been discussed for a long time, has manifested itself in full force. Many of the foundational, widely accepted concepts that were used to explaine the post-Soviet transformations—and seemed dependable—have been discredited or called into question. The roundtable, which took place in Helsinki in October 2022, was not so naive as to seek to solve any problems. The discussion that took place was an attempt to feel out and confront the underlying concepts and assumptions that have failed, as well as an attempt to capture scholarly reflections on the difficult situation that we are living through now

Drastic impacts of 8th October earthquake in Kashmir and role of sustainable development

The main environmental loses from the earthquake to the environment were the heavy landslides, destruction of residential and commercial structures, destruction and rerouting of water bodies, etc. Due to the lack of sustainable planning and awareness, debris, building waste materials and misuse of other materials are seriously spoiling the sustainability of the area. Detail survey of the ruined areas of Kashmir due to 8th October earthquake after five years has been performed during this research. Present conditions of the study area are presenting the worst picture. Improper management of dumped construction waste is one of the serious issues. Environmental and sustainability conditions before and after earthquake are compared in this research work. It is concluded that infrastructure development and building construction during last five years after the earthquake are not fulfilling the sustainability requirement. Proper waste handing, recycling of materials, promotion of indigenous building materials and awareness among the local dwellers may help to improve the sustainability and environmental conditions in the study area

Mechanisms for Increasing Federally-Funded Research at VCU: A Pilot Study of Forty Faculty in Pursuit of NIH Funding in Women\u27s Health

The Strategic Plan for Virginia Commonwealth University (VCU) describes research as an integral and essential component of the University. The Plan promotes scholarly activities of VCU faculty and encourages research in all areas that demonstrate potential for faculty growth and development. Specifically, one of the goals in the VCU Strategic Plan is to achieve ranking among the top fifty universities in the United States in terms of external funding for research. The Office of the Vice President for Research has played a lead role in this initiative. Current economic concerns and budget deficits in the State of Virginia have had a significant impact upon State institutions, including VCU. Substantial budget cuts have adversely impacted University operations as well as faculty and student motivation and morale. It is within such an economic climate that external funding of research becomes even more important. Not only must VCU safeguard existing grant resources, but it must continue to identify and support mechanisms that will increase external funding of faculty research

TLR7 ligation augments hematopoiesis in Rps14 (uS11) deficiency via paradoxical suppression of inflammatory signaling

Myelodysplastic syndrome (MDS) is a hematological malignancy characterized by blood cytopenias and predisposition to acute myeloid leukemia (AML). Therapies for MDS are lacking, particularly those that have an impact in the early stages of disease. We developed a model of MDS in zebrafish with knockout of Rps14, the primary mediator of the anemia associated with del(5q) MDS. These mutant animals display dose- and age-dependent abnormalities in hematopoiesis, culminating in bone marrow failure with dysplastic features. We used Rps14 knockdown to undertake an in vivo small-molecule screening, to identify compounds that ameliorate the MDS phenotype, and we identified imiquimod, an agonist of Toll-like receptor-7 (TLR7) and TLR8. Imiquimod alleviates anemia by promoting hematopoietic stem and progenitor cell expansion and erythroid differentiation, the mechanism of which is dependent on TLR7 ligation and Myd88. TLR7 activation in this setting paradoxically promoted an anti-inflammatory gene signature, indicating cross talk via TLR7 between proinflammatory pathways endogenous to Rps14 loss and the NF-κB pathway. Finally, in highly purified human bone marrow samples from anemic patients, imiquimod led to an increase in erythroid output from myeloerythroid progenitors and common myeloid progenitors. Our findings have both specific implications for the development of targeted therapeutics for del(5q) MDS and wider significance identifying a potential role for TLR7 ligation in modifying anemia

HARP/ACSIS: A submillimetre spectral imaging system on the James Clerk Maxwell Telescope

This paper describes a new Heterodyne Array Receiver Programme (HARP) and Auto-Correlation Spectral Imaging System (ACSIS) that have recently been installed and commissioned on the James Clerk Maxwell Telescope (JCMT). The 16-element focal-plane array receiver, operating in the submillimetre from 325 to 375 GHz, offers high (three-dimensional) mapping speeds, along with significant improvements over single-detector counterparts in calibration and image quality. Receiver temperatures are $\sim$120 K across the whole band and system temperatures of $\sim$300K are reached routinely under good weather conditions. The system includes a single-sideband filter so these are SSB figures. Used in conjunction with ACSIS, the system can produce large-scale maps rapidly, in one or more frequency settings, at high spatial and spectral resolution. Fully-sampled maps of size 1 square degree can be observed in under 1 hour. The scientific need for array receivers arises from the requirement for programmes to study samples of objects of statistically significant size, in large-scale unbiased surveys of galactic and extra-galactic regions. Along with morphological information, the new spectral imaging system can be used to study the physical and chemical properties of regions of interest. Its three-dimensional imaging capabilities are critical for research into turbulence and dynamics. In addition, HARP/ACSIS will provide highly complementary science programmes to wide-field continuum studies, and produce the essential preparatory work for submillimetre interferometers such as the SMA and ALMA.Comment: MNRAS Accepted 2009 July 2. 18 pages, 25 figures and 6 table

Consumers’ Perceptions about Edible Insects’ Nutritional Value and Health Effects: Study Involving 14 Countries

Download PDFsettingsOrder Article Reprints This is an early access version, the complete PDF, HTML, and XML versions will be available soon. Open AccessFeature PaperArticle Consumers’ Perceptions about Edible Insects’ Nutritional Value and Health Effects: Study Involving 14 Countries by Raquel P. F. Guiné 1,*ORCID,Sofia G. Florença 1ORCID,Cristina A. Costa 1ORCID,Paula M. R. Correia 1ORCID,Nada M. Boustani 2ORCID,Irina Matran 3ORCID,Krešimir Jakšić 4ORCID,Cristina Chuck-Hernández 5ORCID,Elena Bartkiene 6ORCID,Ilija Djekic 7ORCID,Maria Papageorgiou 8ORCID,Leticia G. Arias 9ORCID,Malgorzata Korzeniowska 10ORCID,Maša Černelič-Bizjak 11ORCID,Dace Klava 12ORCID,Vanessa Ferreira 13ORCID,Emel Damarli 14ORCID andManuela Ferreira 15ORCID 1 CERNAS-IPV Research Centre, Polytechnic University of Viseu, 3504-510 Viseu, Portugal 2 Faculty of Business and Administration, Saint Joseph University, Beirut 1104 2020, Lebanon 3 Department of Community Nutrition and Food Safety, George Emil Palade University of Medicine, Pharmacy, Science, and Technology of Targu Mures, 540139 Targu Mures, Romania 4 Department of Psychology, University of Zadar, 23000 Zadar, Croatia 5 Tecnologico de Monterrey, The Institute for Obesity Research, Monterrey 64849, Mexico 6 Department of Food Safety and Quality, Lithuanian University of Health Sciences, LT-47181 Kaunas, Lithuania 7 Department of Food Safety and Quality Management, Faculty of Agriculture, University of Belgrade, 11000 Belgrade, Serbia 8 Department of Food Science and Technology, International Hellenic University, 57001 Thessaloniki, Greece 9 BALAT Research Group, Faculty of Veterinary Medicine, University of León, 24071 León, Spain 10 Faculty of Food Science, Wroclaw University of Environmental and Life Sciences, 51-630 Wrocław, Poland add Show full affiliation list * Author to whom correspondence should be addressed. Animals 2024, 14(11), 1631; https://doi.org/10.3390/ani14111631 Submission received: 6 May 2024 / Revised: 25 May 2024 / Accepted: 29 May 2024 / Published: 30 May 2024 Downloadkeyboard_arrow_down Versions Notes Simple Summary Climate change is one of the drivers of change towards sustainable food systems food security. Therefore, food security is a priority all around the world and across different sectors of society. Edible insects are recommended as a sustainable source of food of animal origin, but their acceptance is very diverse across cultures and countries. Therefore, our work investigated the perceptions of consumers about edible insects in 14 countries. We concluded that depending on origin, the level of knowledge is different, which is a starting point to design more focused campaigns to promote EIs, not only in non-insect-eating countries, but also in insect-eating countries. Better knowledge about the health effects of EIs and their nutritive value is a driver of change. Abstract Insects have been consumed for time immemorial in many regions of the globe. However, in other parts, they are not traditionally eaten. Because they are a more sustainable source of animal protein and provide valuable nutrients as well as bioactive compounds with beneficial effects on the human body, their consumption is encouraged. Knowledge can serve as a tool for better acceptance of insects as food. In this context, the present work investigated the knowledge about the nutritional value and health effects of edible insects in different countries. Data were collected by employing a questionnaire survey translated into the different languages of all participating countries and were treated using statistical tools. A total of 7222 responses were obtained. The results indicated that for many issues, the participants manifested a neutral opinion (neither agree nor disagree), but the participants who manifested agreement/disagreement were generally well informed. They were also able to identify untrue facts and answer accordingly by disagreeing. Factor analysis showed four groups of questions: nutritive value, negative perception and risks, safety and benefits of insects and contamination and harmful components. Finally, significant differences were observed according to the sociodemographic variables studies (sex, age, education, living environment and country), with age and country being the most influential of the sociodemographic factors on knowledge. Therefore, increasing knowledge is envisaged as an essential factor in augmenting the recognition of edible insects as a nutritional food, presenting health benefits apart from being a more sustainable source of animal protein when compared with beef or pork meats.info:eu-repo/semantics/publishedVersio

A consensus linkage map for molecular markers and Quantitative Trait Loci associated with economically important traits in melon (Cucumis melo L.)

Background A number of molecular marker linkage maps have been developed for melon (Cucumis melo L.) over the last two decades. However, these maps were constructed using different marker sets, thus, making comparative analysis among maps difficult. In order to solve this problem, a consensus genetic map in melon was constructed using primarily highly transferable anchor markers that have broad potential use for mapping, synteny, and comparative quantitative trait loci (QTL) analysis, increasing breeding effectiveness and efficiency via marker-assisted selection (MAS). Results Under the framework of the International Cucurbit Genomics Initiative (ICuGI, http://www.icugi.org webcite), an integrated genetic map has been constructed by merging data from eight independent mapping experiments using a genetically diverse array of parental lines. The consensus map spans 1150 cM across the 12 melon linkage groups and is composed of 1592 markers (640 SSRs, 330 SNPs, 252 AFLPs, 239 RFLPs, 89 RAPDs, 15 IMAs, 16 indels and 11 morphological traits) with a mean marker density of 0.72 cM/marker. One hundred and ninety-six of these markers (157 SSRs, 32 SNPs, 6 indels and 1 RAPD) were newly developed, mapped or provided by industry representatives as released markers, including 27 SNPs and 5 indels from genes involved in the organic acid metabolism and transport, and 58 EST-SSRs. Additionally, 85 of 822 SSR markers contributed by Syngenta Seeds were included in the integrated map. In addition, 370 QTL controlling 62 traits from 18 previously reported mapping experiments using genetically diverse parental genotypes were also integrated into the consensus map. Some QTL associated with economically important traits detected in separate studies mapped to similar genomic positions. For example, independently identified QTL controlling fruit shape were mapped on similar genomic positions, suggesting that such QTL are possibly responsible for the phenotypic variability observed for this trait in a broad array of melon germplasm. Conclusions Even though relatively unsaturated genetic maps in a diverse set of melon market types have been published, the integrated saturated map presented herein should be considered the initial reference map for melon. Most of the mapped markers contained in the reference map are polymorphic in diverse collection of germplasm, and thus are potentially transferrable to a broad array of genetic experimentation (e.g., integration of physical and genetic maps, colinearity analysis, map-based gene cloning, epistasis dissection, and marker-assisted selection).This work was supported in part by SNC Laboratoire ASL, Ruiter Seeds B.V., Enza Zaden B.V., Gautier Semences S.A., Nunhems B.V., Rijk Zwaan B.V., Sakata Seed Inc, Semillas Fito S. A., Seminis Vegetable Seeds Inc, Syngenta Seeds B. V., Takii and Company Ltd, Vilmorin & Cie S. A., and Zeraim Gedera Ltd (all of them as part of the support to the ICuGI); the grants AGL2009-12698-C02-02 from the Spanish "Ministerio de Ciencia e Innovacion" to AJM. NK lab was supported in part by Research Grant Award No. IS-4223-09C from BARD, the United States - Israel Binational Agricultural Research and Development Fund, and in part by Israel Science Foundation Grant No. 38606, De Ruiter Seeds, Enza Zaden, Keygene, Rijk Zwaan, Sakata Seed Corporation, Semillas Fito, Syngenta Seeds and Vilmorin Clause & Cie. AD was supported by a JAE-Doc contract from "Consejo Superior de Investigaciones Cientificas" (CSIC-Spain). MF was supported by a postdoctoral contract from CRAG. The research carried out at YX's laboratory was supported by Chinese funds (Grant No. 2008-Z42(3), 5100001, 2010AA101907).Díaz Bermúdez, A.; Fergany, M.; Formisano, G.; Ziarsolo, P.; Blanca Postigo, JM.; Fei, Z.; Staub, JE.... (2011). A consensus linkage map for molecular markers and Quantitative Trait Loci associated with economically important traits in melon. BMC Plant Biology. 11. https://doi.org/10.1186/1471-2229-11-111S1

HLA II class alleles in juvenile idiopathic arthritis patients with and without temporomandibular joint arthritis

Publisher Copyright: © 2016 Davidsone et al. Copyright: Copyright 2017 Elsevier B.V., All rights reserved.Background: Temporomandibular joint (TMJ) arthritis is seen very often (38-87 %) in children with juvenile idiopathic arthritis (JIA). With contrast enhanced magnetic resonance imaging (MRI) we can detect more cases of TMJ arthritis than ever before. Previous studies show that HLA II class alleles may have protective or risk importance in JIA subtypes. Our objective is to identify HLA II class alleles of risk and protection in JIA patients with TMJ arthritis. Methods: During the period from 2010 to 2015 MRI for TMJ was performed in 85 JIA patients who were genotyped for HLA- DRB1; DQB1 and DQA1 using RT-PCR with sequence-specific primers. As a control group, data of 100 individuals were taken from the genetic bank of RSU Joint Laboratory of Clinical Immunology and Immunogenetics. Associations of DRB1; DQB1; DQA1 alleles in patients were examined individually using the χ 2 test. P-value (<0.05) and odds ratio were calculated using EPI INFO 6.0 software. Results: Out of 85 JIA patients with mean age of 13.7 ± 3.0 years (range 6.9-17.9 years), 59 (69 %) were girls and 26 (31 %) were boys. The mean duration of the disease was 3.07 ± 2.35 years (range 0.2-11.0 year). JIA subtypes were as follows: seronegative polyarthritis 51 (60 %), seropositive polyarthritis 6(7 %), oligoarthritis extended 7(8 %), oligoarthritis persistent 2 (2 %) arthritis with enthesitis 14 (17 %), undifferentiated 3 (4 %) and 2 (2 %) systemic arthritis. Two groups where separated after TMJ MRI exam: first with at least two signs of active inflammation and/or any structural damage (n = 62); second with no pathologic signs or with slight contrast enhancement (n = 23). We discovered that there are risk alleles that are found in all JIA patient's groups (MRI positive and negative groups) versus controls such as DRB1*07:01, DQB1*03:03; DQB1*05:01. Also some protective alleles as DRB1*18:01, DQB1*06:02-8 were found in overall JIA group. Alleles DRB1*12:01, DQB1*03:01; DQA1*05:01 were found to be protective for TMJ arthrits. Conclusion: In our study there were no convincing risk alleles, but there are alleles that probably are protective for TMJ arthritis like DRB1*12:01, DQB1*03:01; DQA1*05:01.publishersversionPeer reviewe