Bell�s palsy following growth hormone therapy in a patient with Prader-Willi syndrome: The first report

Prader�Willi Syndrome (PWS) is a complex genetic disorder with different manifestations in infancy and childhood including obesity, type 2 diabetes mellitus, mild to moderate intellectual impairment and learning disabilities. In this syndrome, growth hormone therapy improves outcomes. For the first time, here we report an 11-year-old boy with PWS who presented with three episodes of unilateral facial palsy after starting growth hormone therapy. © 2017 The Authors

Implementação de um Programa de Fiabilidade para uma frota de helicópteros Kamov Ka-32A11BC

Este trabalho teve por objetivo o estudo para a implementação de um Programa de Fiabilidade de acordo com o enquadramento legal providenciado pela Autoridade Nacional de Aviação Civil e de acordo com as espectativas por parte de uma empresa de aviação executiva – Everjets. Para tal, utilizou-se como fonte de informação a frota de helicópteros Kamov Ka-32A11BC para a qual foi desenvolvida uma metodologia que providencia o reporte, análise e o controlo dos elementos de fiabilidade. Os resultados desta dissertação propõem uma implementação de forma a identificar os problemas afetos à frota da Everjets, permitindo melhorar os seus índices de fiabilidade através de uma análise continuada.This dissertation is motivated by Everjet’s - executive aviation business ambition to conceive a Reliability Program Kamov Ka-32A11BC helicopter’ fleet. This program was developed within the bounds of the Portuguese Civil Aviation Authority and Everjets expectancies and operational limitations. To fulfil these requirements, this study developed a methodology that is settled upon the bases of data collection, processing and analysis. The implementation of this procedure allowed to identify operational problems and to further improve reliability throughout its continuous analysis

Identification of differential expressed transcripts of almond (Prunus dulcis ‘Sefied’) in response to water-deficit stress by cDNA-AFLP

Drought is the major abiotic stress with adverse effects on growth and productivity of plants. It induces the expression of various genes that are involved in stress response and tolerant/sensitive phenotypes. In this study, the expression of several genes were analyzed in response to dehydration in almond (Prunus dulcis 'Sefied') to shed light on the underlying genetic basis of water-deficit tolerance in almond. The advantages of using almond as a model system for studying dehydration tolerance in woody species are its small diploid genome and its adaptation to drought. Differential expression technique, cDNA-AFLP (amplified fragment length polymorphism), was used to find transcripts accumulated in young trees subjected to water-deficit treatment. Twenty transcript-derived fragments (TDFs) with differential expression between control and stress conditions were generated, amplified, and sequenced. The TDFs showing high homology with genes having known functions were validated by quantitative real-time PCR and their possible function(s) were discussed. These genes include: 2-deoxyglucose-6-phosphate phosphatase, protein kinase MK5 (AFC2) and urease, which up-regulated by 1.61, 2.39 and 4.87 fold under the water-deficit stress condition, respectively. In addition, network analysis unraveled a drought response mechanism displaying activation of the ABA signaling pathway via phosphorylation by 2-deoxyglucose-6-phosphate phosphatase and protein kinase MK5. Protein kinase MK5 was found to be a central element in the drought response network, displaying numerous interactions with RNA-splicing proteins, the sugar-mediated signaling pathway and an epigenetics response (histone phosphorylation).Maryam Shirani Bidabadi, Behrouz Shiran, Hossein Fallahi, Fariba Rafiei, Fazileh Esmaeili & Esmaeil Ebrahimi

Iron Deficiency and Acute Seizures: Results from Children Living in Rural Kenya and a Meta-Analysis

There are conflicting reports on whether iron deficiency changes susceptibility to seizures. We examined the hypothesis that iron deficiency is associated with an increased risk of acute seizures in children in a malaria endemic area

Monitoring of laboratory reared of Phlebotomus papatasi (Diptera: Psychodidae), main vector of zoonotic cutaneous leishmaniasis to different imagicides in hyper endemic areas, Isfahan Province, Iran

Background: In domestic and per domestic area,insecticides such as DDT, malathion, fenitrothion, propoxur and, more recently, synthetic pyrethroids such as deltamethrin and lambda-cyhalothrin, have been successfully used to control sand flies in many countries. The present study reports the results of time-mortality bioassay to DDT 4, lambda-cyhalothrin 0.05, permethrin 0.75, cyfluthrin 0.15 and deltamethrin 0.05 in recently colonized Phlebotomus papatasi populations in Iran. Methods: The insecticide susceptibility status of P. papatasi laboratory population was assessed during 2016�2017, following the standard WHO technique for mosquito (WHO, 2013) based on diagnostic dose. Sand flies collected from rural area of Badrood (Matin Abad), Natanz County, Esfahan Province, using aspirator. Results: Susceptibility test to DDT and pyrethroids was assessed on 3534 laboratory-reared P. papatasi (1746 females and 1788 males). The LT50 and LT90 values were measured using probit analysis and regression lines. The test results against males of P. papatasi revealed that LT50 values to DDT 4, Permethrin 0.75, Deltamethrin 0.05, Cyfluthrin 0.15 and Lambdacyhalothrin 0.05 were 439.28, 108.90, 97.75, 5.00 and 57.84 seconds. The figures for females were 641.62, 136.15, 146.44, 8.71 and 72.69 seconds, respectively. Conclusion: According to presented results, the reared population of sand flies collected from a hyper-endemic region of Esfahan Province is still susceptible to prethroids and Resistance candidate to DDT 4. © 2020 Tehran University of Medical Sciences. All rights reserved