5-year outcomes of single iStent (G1) trabecular microbypass implantation with phacoemulsification in moderately advanced primary open angle glaucoma

Purpose: To evaluate the safety and efficacy of combined phacoemulsification and single iStent (G1) (iStent, Glaukos Corp. San Clemente, USA), implantation in moderately advanced primary open angle glaucoma (POAG) with 5-years follow-up. Methods: Retrospective, interventional case series. All subjects had POAG and underwent single iStent implantation+ phaco+IOL by a single surgeon, with 5 years follow-up. Primary outcome measures: reduction in intraocular pressure (IOP) and proportion of eyes achieving at least 20% reduction of IOP at 5 years. Secondary outcome measures: number of glaucoma drops at 1 through to 5 years; change in visual field mean deviation (MD) at year 5 compared to baseline. Results: 35 eyes of 26 patients were included. Mean (sd) medicated pre-op IOP was 18.5 (3.2) mm Hg on mean (sd) 2.3 (1.0) medications. Mean IOP was reduced to 15.9 (4.5) mm Hg on 2.2 (0.9) drops, 15.0mm (4.5) mm Hg on 2.3 (0.9) drops, 15.6 (3.6) mm Hg on 2.5 (1.0) drops, 15.7 (4.43) mmHg on 2.6 (1.0) drops and 14.7 (3.02) mmHg (P<0.001) on 2.7 (1.14) drops (P = 0.06) from 1 through to 5 years. At year 5, 62% of eyes had achieved at least 20% reduction in IOP. MD reduced from -8 (8.1) dB to -10.7 (13.4) dB over 5 years (p = 0.8) at 0.54dB/ annum. One eye required filtering surgery. There were no sight-threatening complications.Conclusion: This study showed sustained IOP reduction and excellent safety profile for single iStent implantation. Uniquely it provides data for a more severe stage of glaucoma, and also visual field data, which indicated no significant change through 5 years

Biodesulfurization of dibenzothiophene by Shewanella putrefaciens NCIMB 8768

The desulfurization ability of Shewanella putrefaciens strain NCIMB 8768 was studied and its activity profile was compared with the widely studied strain Rhodococcus erythropolis strain IGTS8. Dibenzothiophene (DBT) is a recalcitrant thiophenic component of fossil fuels especially among diesel blend stocks. DBT in basic salt medium (BSM) at a final concentration of 0.3, 0.6 and 0.9 mM was supplied to the microbes as the sole sulfur source. Experimental results showed that S. putrefaciens, similar to other biodesulfurization organisms, converted DBT to the end product 2-hydroxybiphenyl (HBP), as detected by the Gibbs assay and HPLC. Cells cultivated in medium containing 0.3 mM of DBT showed the highest desulfurization activity, with a maximum specific production rate 43.5 mmol/L of HBP

Existence and Classification of Solutions to Nonlinear Elliptic Equations

The so-called Lane-Emden equation is a model in astrophysics, useful to problems in analysis and conformal geometry, and is closely related to the Yamabe Problem and the Uniformization Theorem. We discuss several important results for the equation, which include proving that the equation admits a distribution solution if and only if p is greater than the Serrin exponent, that classical solutions admit the form of a bubble function if p is equal to the Sobolev exponent, and no classical solutions exist for p less than the Sobolev exponent. A new proof of an extended result is also included

DBT degradation enhancement by decorating Rhodococcus erythropolis IGST8 with magnetic Fe3O4 nanoparticles

Biodesulfurization (BDS) of dibenzothiophene (DBT) was carried out by Rhodococcus erythropolis IGST8 decorated with magnetic Fe3O4 nanoparticles, synthesized in-house by a chemical method, with an average size of 45-50 nm, in order to facilitate the post-reaction separation of the bacteria from the reaction mixture. Scanning electron microscopy (SEM) showed that the magnetic nanoparticles substantially coated the surfaces of the bacteria. It was found that the decorated cells had a 56% higher DBT desulfurization activity in basic salt medium (BSM) compared to the nondecorated cells. We propose that this is due to permeabilization of the bacterial membrane, facilitating the entry and exit of reactant and product, respectively. Model experiments with black lipid membranes (BLM) demonstrated that the nanoparticles indeed enhance membrane permeability

Structure and properties relationships in poly(vinyl chloride)

This work has been undertaken to study the relationships between structure and properties of commercial poly(vinyl chloride) within the time-scale of processing and thermal treatment. Two commercial grade resins (mass and suspension) have been used for this study. PVC resins were dry blended in the T.K. Fielder dry blending machine. Tin stabiliser and calcium stearate lubricant were added to the PVC to obtain clear moulded sheets. [Continues.

Signal recovery from wavelet transform maxima

Cataloged from PDF version of article.This paper presents an iterative algorithm for signal recovery from discrete-time wavelet transform maxima. The signal recovery algorithm is developed by using the method of projections onto convex sets. Convergence of the algorithm is assured

Temperature-sensitive protein–DNA dimerizers

Programmable DNA-binding polyamides coupled to short peptides have led to the creation of synthetic artificial transcription factors. A hairpin polyamide-YPWM tetrapeptide conjugate facilitates the binding of a natural transcription factor Exd to an adjacent DNA site. Such small molecules function as protein-DNA dimerizers that stabilize complexes at composite DNA binding sites. Here we investigate the role of the linker that connects the polyamide to the peptide. We find that a substantial degree of variability in the linker length is tolerated at lower temperatures. At physiological temperatures, the longest linker tested confers a "switch"-like property on the protein-DNA dimerizer, in that it abolishes the ability of the YPWM moiety to recruit the natural transcription factor to DNA. These observations provide design principles for future artificial transcription factors that can be externally regulated and can function in concert with the cellular regulatory circuitry

Sistem Pakar Kerusakan Motor Kendaraan Roda Dua Jenis Yamaha Matic pada Reza Jaya Motor Samarinda

Tulisan ini memuat bagaimana melakukan diagnosa kerusakan pada motor Yamaha matic dengan menggunakan metode Forward Chaining dan Certainty Factor Sebagai tolak ukur tingkat kepercayaan dari sistem. Forward Chaining sebuah metode Pencocokan fakta atau pernyataan dimulai dari bagian sebelah kiri. Dengan kata lain, penalaran dimulai dari fakta terlebih dahulu, lalu dicari rule yang sesuai dengan fakta – fakta dengan menginputkan dari macam kerusakan, ke fakta Gejala yang dirasakan pengguna untuk menguji kebenaran hipotesa sehinggga menghasilkan sebuah atau beberapa solusi. Metode pengembangan sistem yang digunakan pada tulisan ini menggunakan waterfall. Adapun langkah – langkah dari waterfall itu sendiri yaitu: Kebutuhan Sistem, Spesifikasi Kebutuhan Sistem perangkat lunak, Design perangkat lunak, Implementasi perangkat lunak, Uji mesin formal, operasi dan perawatan sistem. Metode pe ngujian yang di gunakan di dalam tulisan ini menggunakan white box dan Black box. Aplikasi yang dikembangkan digunakan untuk mengetahui gejala-gejala kerusakan dan mencari solusi yang tepat terhadap kerusakan yang dialami terhadap kendaraan roda dua jenis Yamaha merk mio soul pada Reza Jaya Motor Samarinda, agar teknisi dapat mengetahui segaja jenis kerusakan terdapat kendaraan yang masuk untuk diservice atau diperbaiki

Analysis of Residue Probability Density Function and Comparator Offset Error in Pipelined ADCs

This paper presents a new approach to analyze the convergence of residue probability density function (pdf) in pipelined ADCs. Compared to the previous approaches, in the proposed approach, in addition to the analysis of residue pdfs for different input densities, the analysis of the sub-ADC comparator offsets impact on output pdf is possible. Using Fourier analysis, it will be shown that the residue density converges to uniformity. In the half-bit redundant structure, residue pdf concentrates in the center half of the stage full-scale range and 6 dB of extra resolution can be gained. Also, the share of each stage in this resolution improvement is investigated. Examining the sub-ADC threshold offsets impact on residue pdfs, it is observed that with respect to the impact on converter additional resolution, the final stages offset errors are more significant than the first stages offsets