1 research outputs found
ΠΡΠ΅Π½ΠΊΠ° ΡΠΎΠΎΡΠ½ΠΎΡΠ΅Π½ΠΈΡ ΠΏΡΠΎΠ»ΠΈΡΠ΅ΡΠ°ΡΠΈΠΈ ΠΈ Π°ΠΏΠΎΠΏΡΠΎΠ·Π° Π² ΡΠΊΠ°Π½ΠΈ ΠΌΠΎΠ»ΠΎΡΠ½ΠΎΠΉ ΠΆΠ΅Π»Π΅Π·Ρ Π² Π½ΠΎΡΠΌΠ΅ ΠΈ ΠΏΡΠΈ Π³ΠΈΠΏΠ΅ΡΠΏΡΠΎΠ»ΠΈΡΠ΅ΡΠ°ΡΠΈΠ²Π½ΡΡ ΠΏΡΠΎΡΠ΅ΡΡΠ°Ρ
The study was conducted to determine the universal indices reflecting the balance of proliferation and apoptosis in breast tissue in normal and various pathological processes. The 27 values of the apoptosis level and the number of cells in different phases of the cell cycle were determined in the biopsy material of samples of cancer, fibroadenoma tissues and unchanged breast tissue by flow cytometry. The balance of apoptosis and proliferation in the studied tissues was evaluated and indices were proposed to reflect the activity of these processes in the tissue. It is shown that in hyperproliferative processes of the breast the cell balance estimated by the proposed indices has been changed in the direction of increasing of the cell population.ΠΡΡΠ»Π΅Π΄ΠΎΠ²Π°Π½ΠΈΠ΅ ΠΏΡΠΎΠ²Π΅Π΄Π΅Π½ΠΎ Ρ ΡΠ΅Π»ΡΡ ΠΎΠΏΡΠ΅Π΄Π΅Π»Π΅Π½ΠΈΡ ΡΠ½ΠΈΠ²Π΅ΡΡΠ°Π»ΡΠ½ΡΡ
ΠΈΠ½Π΄Π΅ΠΊΡΠΎΠ², ΠΎΡΡΠ°ΠΆΠ°ΡΡΠΈΡ
Π±Π°Π»Π°Π½Ρ ΠΏΡΠΎΡΠ΅ΡΡΠΎΠ² ΠΏΡΠΎΠ»ΠΈΡΠ΅ΡΠ°ΡΠΈΠΈ ΠΈ Π°ΠΏΠΎΠΏΡΠΎΠ·Π° Π² ΡΠΊΠ°Π½ΡΡ
ΠΌΠΎΠ»ΠΎΡΠ½ΠΎΠΉ ΠΆΠ΅Π»Π΅Π·Ρ Π² Π½ΠΎΡΠΌΠ΅ ΠΈ ΠΏΡΠΈ ΡΠ°Π·Π»ΠΈΡΠ½ΡΡ
ΠΏΠ°ΡΠΎΠ»ΠΎΠ³ΠΈΡΠ΅ΡΠΊΠΈΡ
ΠΏΡΠΎΡΠ΅ΡΡΠ°Ρ
. Π Π±ΠΈΠΎΠΏΡΠΈΠΉΠ½ΠΎΠΌ ΠΌΠ°ΡΠ΅ΡΠΈΠ°Π»Π΅ ΠΎΠ±ΡΠ°Π·ΡΠΎΠ² ΡΠ°ΠΊΠ° ΠΌΠΎΠ»ΠΎΡΠ½ΠΎΠΉ ΠΆΠ΅Π»Π΅Π·Ρ, ΡΠΊΠ°Π½Π΅ΠΉ ΡΠΈΠ±ΡΠΎΠ°Π΄Π΅Π½ΠΎΠΌΡ ΠΈ Π½Π΅ΠΈΠ·ΠΌΠ΅Π½Π΅Π½Π½ΠΎΠΉ ΡΠΊΠ°Π½ΠΈ ΠΌΠΎΠ»ΠΎΡΠ½ΠΎΠΉ ΠΆΠ΅Π»Π΅Π·Ρ ΠΌΠ΅ΡΠΎΠ΄ΠΎΠΌ ΠΏΡΠΎΡΠΎΡΠ½ΠΎΠΉ ΡΠΈΡΠΎΡΠ»ΡΠΎΡΠΎΠΌΠ΅ΡΡΠΈΠΈ ΠΎΠΏΡΠ΅Π΄Π΅Π»Π΅Π½Ρ Π·Π½Π°ΡΠ΅Π½ΠΈΡ ΡΡΠΎΠ²Π½Ρ Π°ΠΏΠΎΠΏΡΠΎΠ·Π° ΠΈ ΠΊΠΎΠ»ΠΈΡΠ΅ΡΡΠ²ΠΎ ΠΊΠ»Π΅ΡΠΎΠΊ Π²ΡΠ°Π·Π½ΡΡ
ΡΠ°Π·Π°Ρ
ΠΊΠ»Π΅ΡΠΎΡΠ½ΠΎΠ³ΠΎ ΡΠΈΠΊΠ»Π°. ΠΠ° ΠΎΡΠ½ΠΎΠ²Π°Π½ΠΈΠΈ Π°Π½Π°Π»ΠΈΠ·Π° ΠΏΠΎΠ»ΡΡΠ΅Π½Π½ΡΡ
ΡΠ΅Π·ΡΠ»ΡΡΠ°ΡΠΎΠ² Π²ΡΠΏΠΎΠ»Π½Π΅Π½Π° ΠΎΡΠ΅Π½ΠΊΠ° Π±Π°Π»Π°Π½ΡΠ° ΠΏΡΠΎΡΠ΅ΡΡΠΎΠ² Π°ΠΏΠΎΠΏΡΠΎΠ·Π° ΠΈ ΠΏΡΠΎΠ»ΠΈΡΠ΅ΡΠ°ΡΠΈΠΈ Π² ΠΈΡΡΠ»Π΅Π΄ΡΠ΅ΠΌΡΡ
ΡΠΊΠ°Π½ΡΡ
ΠΈ ΠΏΡΠ΅Π΄Π»ΠΎΠΆΠ΅Π½Ρ ΠΈΠ½Π΄Π΅ΠΊΡΡ, ΠΎΡΡΠ°ΠΆΠ°ΡΡΠΈΠ΅ Π°ΠΊΡΠΈΠ²Π½ΠΎΡΡΡ Π΄Π°Π½Π½ΡΡ
ΠΏΡΠΎΡΠ΅ΡΡΠΎΠ² Π² ΡΠΊΠ°Π½ΠΈ. ΠΠΎΠΊΠ°Π·Π°Π½ΠΎ, ΡΡΠΎ ΠΏΡΠΈ Π³ΠΈΠΏΠ΅ΡΠΏΡΠΎΠ»ΠΈΡΠ΅ΡΠ°ΡΠΈΠ²Π½ΡΡ
ΠΏΡΠΎΡΠ΅ΡΡΠ°Ρ
ΠΌΠΎΠ»ΠΎΡΠ½ΠΎΠΉ ΠΆΠ΅Π»Π΅Π·Ρ ΠΊΠ»Π΅ΡΠΎΡΠ½ΡΠΉ Π±Π°Π»Π°Π½Ρ, ΠΎΡΠ΅Π½Π΅Π½Π½ΡΠΉ Ρ ΠΏΠΎΠΌΠΎΡΡΡ ΠΏΡΠ΅Π΄Π»ΠΎΠΆΠ΅Π½Π½ΡΡ
ΠΈΠ½Π΄Π΅ΠΊΡΠΎΠ², ΠΈΠ·ΠΌΠ΅Π½Π΅Π½ Π² ΡΡΠΎΡΠΎΠ½Ρ ΡΠ²Π΅Π»ΠΈΡΠ΅Π½ΠΈΡ ΠΊΠ»Π΅ΡΠΎΡΠ½ΠΎΠΉ ΠΏΠΎΠΏΡΠ»ΡΡΠΈΠΈ