Formation of Titanium Nanotubes on the Surface of Dental Implants

Abstract This study represents the results of a series of experiments about the formation of titanium dioxide nanotubes on the implants surfaces. Were investigated the obtained uniformity of surface coatings blank in dental implants and the surfaces morphology

ОРАЛЬНЫЕ МУКОЗИТЫ У ПАЦИЕНТОВ С ОНКОЛОГИЧЕСКОЙ ПАТОЛОГИЕЙ ОРОФАРИНГЕАЛЬНОЙ ОБЛАСТИ: ОБЗОР ЛИТЕРАТУРЫ

Oral mucositis is one of the most common effects of chemoradiotherapy in patients with oropharyngeal cancer. The development of oral mucositis is the main cause of interruption of antitumor therapy, which significantly affects the results of treatment of the main disease. Despite the fact that the disease is well studied in the literature, today there is no universal treatment and prevention protocol. The aim of this review is to analyze scientific publications devoted to the problems of etiology, pathogenesis, clinic, diagnosis, treatment and prevention of oral mucositis. © 2020 ABC-press Publishing House. All rights reserved.Оральный мукозит - одно из наиболее частых последствий химиолучевой терапии у пациентов с раком орофарингеальной области. Именно развитие орального мукозита считается основной причиной прерывания противоопухолевой терапии, которое значительно ухудшает результаты лечения онкологического заболевания. Несмотря на то что заболевание хорошо изучено, на сегодняшний день не разработан универсальный общепринятый алгоритм его лечения и профилактики. В данном обзоре представлен анализ научных публикаций, посвященных проблемам этиологии, патогенеза, клинической картины, диагностики, лечения и профилактики орального мукозита

The use of a titanium-containing drug for the prevention of severe degrees of radiation mucositis in patients with metal structures in the oral cavity [Применение титаносодержащего препарата для профилактики тяжелых степеней лучевого мукозита у пациентов с металлоконструкциями в полости рта]

Introduction. Oral mucositis is one of the earliest and most frequent complications of radiation therapy or chemotherapy in patients diagnosed with oropharyngeal cancer. Because of this pathology, therapeutic interventions are most often used, thereby poor treatment is considered an etiological factor of oral mucositis. Now, this issue is being actively studied in the world, but a unified algorithm for treatment and prevention of oral mucositis has not been formed. The study objective – is to evaluate the effect of titanium glycerosolvate aquacomplex in reducing the intensity of radiation induced reactions and reducing the frequency of interruptions. Materials and methods. 52 patients diagnosed with oropharyngeal cancer were included in this study, treated with radiotherapy or chemotherapy. for prophylaxis of severe stages of oral mucositis, 32 patients underwent standard symptomatic therapy (group 1, control group); 20 patients took titanium glycerosolvate aquacomplex in accordance with symptomatic therapy (group 2). Results. In the group 1 only 61.7 % of patients completed treatment. In the group 280 % of patients completely underwent antitumor therapy. At the same time, they developed oral mucositis of the I–II degree. Also, in the group of the studied drug, in 100 % of cases, therapy was performed without interruptions. Conclusion. using titanium glycerosolvate aquacomplex for the prophylaxis of severe stages of oral mucositis during radiotherapy or chemotherapy of oropharyngeal cancer is effective and safe. It is also convenient from the medical and economic side, thanks to the ability to use it on an outpatient basis. © 2022 National University of Science and Technology MISIS. All rights reserved

Interaction of various variants of the nanostructured surface of titanium with mscs isolated from adipose tissue

Titanium has been successfully used in dental implantology for a long time. Due to the osseointegration process, titanium implants are able to withstand the chewing load. This article is devoted to the study of surface treatment methods of titanium alloys and the study of their interaction with mesenchymal stem cells (MSCs). The surface microrelief can influence MSC differentiation in different ways, which subsequently gives it osteogenic potential. The paper proposes modes of surface modification of titanium alloys on Grade 4 and Grade 1 by chemical and electrochemical (anodizing) etching. The possibility of modifying the surface of titanium alloys using the synthesis of graphene layers has been proposed in this paper for the first time. The osteogenic potential of a particular surface was assessed by the number of mesenchymal stem cells cultured on them under identical conditions. © 2021 by the authors. Licensee MDPI, Basel, Switzerland

Biocompatibility and Bioresorption of 3D-Printed Polylactide and Polyglycolide Tissue Membranes

We studied biocompatibility and bioresorption of 3D-printed polylactide and polyglycolide tissue membranes. Ultrasound microscopy and histological examination showed that membranes fabricated of a copolymer of lactic and glycolic acids in a mass ratio of 1:9 are bioresorbed and have good biocompatibility with soft tissues (connective tissue, adipose tissue, and epithelium). An important feature of the copolymer membranes, which differs them from pure polylactide membranes, is the formation of a thin fibrous capsule that did not interfere its destruction by the mechanism of hydrolytic resorption. © 2021, Springer Science+Business Media, LLC, part of Springer Nature