Estimation of Total Saponins and Evaluate Their Effect on in vitro Methanogenesis and Rumen Fermentation Pattern in Wheat Straw Based Diet

The present experiment was carried out to estimate the total saponins and evaluate their effect on methanogenesis and rumen fermentation by in vitro gas production techniques. Three plant material, rough chaff tree seed (Achyranthus aspara, T1), gokhru seed (Tribulus terrestris, T2) and Siris seed (Albizia lebbeck, T3) were selected for present study. The total saponins content in T1, T2 and T3 were 45.75, 25.65 and 48.26% (w/w), respectively. Three levels of each saponins (3, 6 and 9% on DM basis) and wheat straw based (50R:50C) medium fiber diet (200±10 mg) were used for the evaluation of their effect on methanogenesis and rumen fermentation pattern. Results showed the maximum methane reduction (49.66% in term of mM/gDDM) and acetate propionate ration (35.08%) were found in T1 at 6 and 3% levels. Result show that propionate production (mM/ml) was increased; protozoa population decreased (75%) significantly on addition with T3 at 6% level. No significant variation was found in dry matter digestibility in all cases. The present results demonstrate that total saponins extracted from different herbal plants are a promising rumen modifying agent. They have the potential to modulate the methane production, dry matter digestibility and microbial biomass synthesis

ANTIOVULATORY AND ESTROGENIC ACTIVITY OF LEAVES OF DATURA STRAMONIUM LINN. IN FEMALE ALBINO RATS

The effect of petroleum ether (60-8

QSAR studies on aminopyrazoles for the prediction of inhibition of CDK2/Cyclin A as antitumor agents

Cylin dependent kinases (CDKs) have emerged as novel mechanistic target due to their direct involvement in underlying genetic changes during the cancerous state. In order to identify the essential physiochemical parameters for CDK2 inhibitory activity in some 3-aminopyrazole derivatives, Quantitative Structure-Activity Relationship (QSAR) studies have been carried out on a series of total 35 compounds (taking 24 and 11 molecules in trainings set and test set respectively) using the multiple linear regression MLR) method. Among the generated models, the best QSAR model with good correlation coefficient (r2 = 0.643) along high statistical significance (> 99.9 %) well explained variance in activity for both training and test set molecules (Pred. r2 = 0.632). The two dimensional QSAR studies revealed that the activity is positively controlled by the indicator parameter (I), electronic parameter (field effect, F) and hydrophobic fragmentation constant (Fr) of substituents. Apart from that one of the interesting finding is that this model well discriminates between the Molar refractivity (MR) and hydrophobic fragmentation constant (Fr) in prediction of inhibitory activities based on the regression coefficient and associated error. Further the calculation of important descriptors like log P, hydrogen bond donor and acceptors etc. indicates the potential of these molecules in clinical trial as an anticancer drug.Colegio de Farmacéuticos de la Provincia de Buenos Aire

New emerging rare-earth free yellow emitting 2D BCNO nanophosphor for white light emitting diodes

We have demonstrated a new emerging rare-earth free highly-efficient two dimensional (2D) boron carbon oxynitride (BCNO) yellow emitting nanophosphor with high quantum efficiency for white light emitting diode (WLED) devices. This BCNO nanophosphor exhibits 2D layered structures analogous to hexagonal BN phase. Further, the EELS and XPS results confirm the nanophosphor consisted of B, C, N and O elements. The BCNO nanophosphor shows a broad highly intense yellow emission band centered at 580 nm corresponding to 470 nm excitation wavelength with a quantum efficiency approaching 89%. This novel nanophosphor with strong emission has subsequently been integrated to chip on board (CoB) based blue LEDs in order to fabricate WLEDs devices with a color rendering index of 92. Low color temperature (4899) and better CIE color coordinates (x = 0.3496, y = 0.3679) of a fabricated WLEDs device supports a 2D BCNO nanophosphor that could be an exceptional choice for CoB based WLEDs. Hence, our method provides a facile synthesis of rare-earth free 2D lightweight BCNO nanophosphor and its integration with CoB based blue LEDs for next generation advanced solid state white light applications

APPLICATION OF CHALCONE IN SYNTHESIS OF 1-(1, 5- BENZODIAZEPINO) SUBSTITUTED ANALOGUES OF INDOLE

ABSTRACT Versatility of chalcone derivative of 3-substituted-1-{(2E)-1-phenyl-3-(3,4,5)trimethoxyphenyl)}but-2-en-1-one)indole (10-13) and (2Z)-2-(1H-indol-1-yl)-3-(4-substituted phenyl)-1-phenylprop-2-en-1-one (15-18) was explored to provide an easy one pot access to its 1-(1,5-benzodiazepino) substituted analogues (19-22) and (23-26) respectively

An Efficient Approach to the Synthesis of Novel Oxazolidinones as Potential Antimicrobial Agents

Oxazolidinone, either mononuclear or condensed with other heterocyclics, has established its importance in medicinal chemistry. A variety of biological activities have been reported by oxazolidinone derivatives. The present work describes the synthesis of several oxazolidinone derivatives, 3-(2-(7-chloroquinoline-4-ylamino)ethyl)-2-imino-5-(4-chloro/nitro/methoxy benzylidene)oxazolidin-4-one 4(a–c) and 4-(2-(7-chloroquinolin-4-ylamino)ethyl)-2(4-chloro/nitro/methoxy-benzylidene)-1,6-diox-4,9-di-azaspiro[4,4]nonane-3,8-dione 5(a–c). Synthesized compounds (1, 3, 4a, 5a, and 5c) were screened against bacterial strains such as S. aureus (MTCC 96) and E. coli (MTCC119) and fungal strains A. niger (MTCC 1344) and C. albicans (MTCC 871) compared with penicillin for bacteria and fluconazole for fungi as reference drugs by disk diffusion method. All synthesized compounds were identified by the means of IR, NMR, and MS

A Critical Analysis of Fraud Cases on the Internet

We lived in the era of technology, where online websites have made communication and interaction much easier than the early decade. The modern world is changing so quickly, and emerging new trends simplify our lives, but on the other hand, it will also create risks. A website acts as a more admired platform by the user to access the different web applications. Because of the functions of the website, all the data on the website is available in the proper structure, which makes the working environment much convenient and efficient. The websites may undoubtedly be a precious resource for young people, but it may also cause severe problems. It is really easy to build a fake website that looks like an original website where hackers like to deceive consumers and businesses for their own benefits. In this paper, researchers have examined online fraud cases through web applications and how fraudulent websites affect financial loss. Researchers also highlighted the current situation regarding the usage of online services, as well as the threats that have an impact on users. In addition, researchers have suggested that new laws and regulations will be implemented for preventing cybercrime

Probing on green long persistent Eu2+/Dy3+ doped Sr3SiAl4O11 emerging phosphor for security applications

Herein, a novel green emitting long-persistent Sr(3)SiAl(4)O(1)1:Eu2+/Dy3+ phosphor was synthesized in a single phase form using facile solid state reaction method under the reducing atmosphere of 10% H-2 and 90% N-2. The resulting phosphor exhibits hyper-sensitive strong broad green emission, peaking at 510 nm upon 340 nm excitation wavelength, which is attributed to the 4f(6)5d(1)-4f(7) transitions of emission center of europium (Eu2+) ions. Moreover, the incorporation of dysprosium (Dy3+) ions, which act as effective hole trap centers with appropriate depth, largely enhances the photoluminescence characteristics and greatly improves the persistent intense luminescence behavior of Sr3SiAl4O11:Eu2+/Dy3+ phosphor under ultraviolet (UV) excitation. In addition, with the optimum doping concentration and sufficient UV excitation time period, the as-synthesized phosphor can be persisted afterglow for time duration similar to 4 h with maximum luminescence intensity. Thus, these results suggest that this phosphor could be expected as an ultimate choice for next generation advanced luminescent materials in security applications such as latent finger-marks detection, photo-masking induced phosphorescent images, and security code detection

Formation of a gold-carbon dot nanocomposite with superior catalytic ability for the reduction of aromatic nitro groups in water

We report the synthesis of a gold-carbon dot nanocomposite and its utility as a recyclable catalyst for the reduction of aromatic nitro groups. The presence of carbon dots on gold nanosurfaces enhanced the reduction rate by two-fold