"गण्डावतरणम् कथाश्रित भारतीय-चिन्तन-परम्परा एवं उसके आलोक में कवि नीलकंठ दीक्षित विरचित गण्डावतरणम् महाकाव्य का समीक्षात्मक अध्ययन"

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Choroidal osteoma with CNVM – Successful treatment with intravitreal Bevacizumab

AbstractTwenty-seven years old healthy woman presented with complaints of sudden painless blurred vision in right eye for 1week. On examination, visual acuity was 20/30 in the right eye and 20/20 in left eye. Fundus examination OS was normal; OD demonstrated a flat, opaque, yellowish parapapillary choroidal lesion with grayish membrane associated with minimal subretinal fluid suggestive of a CNVM in the center. B-scan ultrasonography revealed findings consistent with a choroidal osteoma. Fundus fluorescein angiography of the right eye revealed a relatively well-defined area of hyperfluorescence that increased in size and intensity in the later phases suggestive of active extrafoveal CNVM. Optical coherence tomography confirmed the extrafoveal CNVM with subfoveal fluid. She was treated with intravitreal Bevacizumab OD. At the 2weeks visit, vision OD improved to 20/20. The FFA and OCT revealed a resolved CNVM. Intravitreal Bevacizumab may be an effective alternative in the management of CNVM secondary to choroidal osteoma

Hyperhomocysteinemia: a risk factor in unexplained infertility

Background: To study the role of hyperhomocysteinemia in unexplained infertility and the impact of its correction with vitamin and mineral supplementation.Methods: Total of 60 patients were included with 30 patients in case and 30 patients in control groups. Cases included patients with history of inability to conceive with frequent regular unprotected intercourse for at least 1 year. Controls included age matched parous females with at least one live birth and no history of abortions. Among the patients of unexplained infertility with hyperhomocysteinemia, homocysteine lowering agents were given and outcome studied in the form of lowering of homocysteine levels and number of conceptions.Results: The mean age was 28.1 years in study and 29.5 years in the control group .Mean level of serum homocysteine was significantly higher in study group than normal fertile women i.e.20.5µmol/l and 10.9 µmol/l respectively. Among the patients of unexplained infertility, 22(73.3%) were found to have range above the normal healthy levels. In these patients homocysteine lowering agents were given for 6 weeks and lowering of mean homocysteine levels was observed which was 10.4 µmol/l.  Six (27.3%) patients conceived spontaneously during the follow up period.Conclusions: Serum homocysteine levels are inversely correlated with infertility. Homocysteine lowering agents have a favourable impact on the outcome of infertility and their use is suggested in cases of unexplained infertility associated with hyperhomocysteinemia.

Studies on Activation of Systemic Acquired Resistance (SAR) by Heterocyclic Compounds Having Azole Groups in Vigna radiata (L.) Wilczek.

Heterocyclic compounds are known to activate the defense response or resistance in plants. In order to study their effect as activatorsof systemic acquired resistance (SAR), two series of heterocyclic compounds having azole group were used for the present study i.e.,substituted triazolothiadiazoles and thiazolidine thioureas to obtain new compounds with improved biological activities in mung beans(Vigna radiata (L.)Wilczek, is an important pulse crop of India. These compounds could be used as a solution to chemically mediateddisease control both at the farm level as well as chemical fungicides. For this polyphenol content, flavonoid content, PAL activity,peroxidase activity and protein content were determined in control and after chemical treatment in mung beans var. ‘RMG-344’. Theresults indicated significant changes and a distinct role of polyphenols, flavonoids, PAL, peroxidase and proteins in the defense responseof mung beans after treatment with these chemicals