It's Just My History Isn't It? Understanding smart journaling practices

Smart journals are both an emerging class of lifelogging applications and novel digital possessions, which are used to create and curate a personal record of one's life. Through an in-depth interview study of analogue and digital journaling practices, and by drawing on a wide range of research around 'technologies of memory', we address fundamental questions about how people manage and value digital records of the past. Appreciating journaling as deeply idiographic, we map a broad range of user practices and motivations and use this understanding to ground four design considerations: recognizing the motivation to account for one's life; supporting the authoring of a unique perspective and finding a place for passive tracking as a chronicle. Finally, we argue that smart journals signal a maturing orientation to issues of digital archiving

Dual PI3K/mTOR Inhibition with BEZ235 Augments the Therapeutic Efficacy of Doxorubicin in Cancer without Influencing Cardiac Function

Cancer continues to be a leading cause death in the United States despite improved treatments. Cancerous lesions form after acquiring oncogenic driver mutations or losing tumor suppressor function in normal cells. Traditional therapies have included use of genotoxic substances that take advantage of the increased growth rate and loss of tumor suppressor function to cause cell death. One such drug is the anthracycline antibiotic doxorubicin (DOX). DOX interchelates into DNA and disrupts transcriptional machinery while also poisoning topoisomerase II. This results in single and double stranded DNA breaks, which if severe enough leads to either necrotic or apoptotic cell death. DOX has been very effective at treating several different cancers and is still widely used today however its clinical use is limited due to cumulative dose dependent cardiotoxicity. Therefore, combination therapy targeting survival pathways is utilized to minimize the cumulative dose of DOX without ameliorating its anti-tumor effects. We investigated the potential anti-cancer effects of combining the dual PI3K/mTOR inhibitor, BEZ235 (BEZ), with DOX in pancreatic, breast and other cancer cells lines as well as its associated effects on the heart. Our results showed that co-treatment of BEZ with DOX increased apoptosis in a manner that was dependent on inhibition of the AKT survival pathway. Moreover, BEZ co-treatment with DOX had additive effects towards cell viability while it significantly enhanced necrotic cell death compared to either drug alone. Furthermore, we observed that physiological concentrations of BEZ inhibited ABCB1 efflux resulting in increased intracellular accumulation of DOX, which led to increased DNA damage. In addition, BEZ in combination with gemcitabine (Gem) reduced cell proliferation but did not enhance necrosis or apoptosis. Treatment with BEZ and DOX in mice bearing tumor xenographs reduced tumor growth as compared to BEZ, DOX or Gem. Moreover, BEZ reduced DOX toxicity in rat myoblast cells and did not potentiate the effects of DOX in tumor-bearing mice. We propose that combining BEZ with DOX could be a novel therapeutic approach for the treatment of patients with cancer in the hope of improving the prognosis of this deadly disease

Potential Impacts of Artificial Intelligence on Spine Imaging Interpretation and Diagnosis

Spine and related disorders represent one of the most common causes of pain and disability in the United States. Imaging represents an important diagnostic procedure in spine care. Imaging studies contain actionable data and insights undetectable through routine visual analysis. Convergent advances in imaging, artificial intelligence (AI), and radiomic methods has revealed the potential of multiscale in vivo interrogation to improve the assessment and monitoring of pathology. AI offers various types of decision support through the analysis of structured and unstructured data. The primary purpose of this qualitative exploratory case study was to identify the potential impacts of AI solutions on spine imaging interpretation and diagnosis. Selected constructs from the diffusion of innovations theory and the technology acceptance model provided the conceptual framework. Data were acquired from 4 consensus-based white papers, researcher reflective journaling, and 2 homogenous focus group sessions comprising radiologists and AI experts. Content and thematic analyses of acquired data were performed with ATLAS.ti. Three primary themes emerged from qualitative analysis: patient-based decision support, population-based decision support, and application-based decision support. Subthemes include multiscale in vivo analysis, naturally language processing, change analysis, prioritization, and ground truth. The results suggest how further development of AI could fundamentally alter how spine pathology is detected, characterized, and classified. The study also addresses the potential impact of AI on in vivo tissue analysis, the differential diagnosis, and imaging workflow. This includes introducing the concept of the virtual biopsy and its use in spine imaging

The Role of Cross-Silo Federated Learning in Facilitating Data Sharing in the Agri-Food Sector

Acknowledgements This work was supported by an award made by the UKRI/EPSRC funded Internet of Food ThingsNetwork+ grant EP/R045127/1.Peer reviewedPostprin

How might technology rise to the challenge of data sharing in agri-food?

Acknowledgement This work was supported by an award made by the UKRI/EPSRC funded Internet of Food Things Network+ grant EP/R045127/1. We would also like to thank Mr Steve Brewer and Professor Simon Pearson for supporting the work presented in this paper.Peer reviewedPostprin

Data Sharing and Interoperability for Data Trusts Workshop : Summary Report

The workshop was supported by an award made by the UKRI, EPSRC funded Internet of Food Things Network+ grant EP/R045127/1. We would like to thank Paul Mayfield, Hannah Rudman, and Steve Brewer for their contributions to the workshop as well as all our participants for your insightful discussionsPublisher PD

Domestic Widgets: Leveraging Household Creativity in Co-Creating Data Physicalisations

The home environment is a complex design space, especially when it has multiple inhabitants. As such, the home presents challenges for the design of smart products. Householders may be different ages and have differing interests, needs, and attitudes towards technology. We pursued a research-through-design study with family households to envision and ‘co-create’ the future of data-enabled artifacts for their homes. We have iteratively developed domestic research artefacts for these households that are open, data-enabled, physical visualizations. These artefacts - called Domestic Widgets - are customisable in their design and functionality throughout their lifespan. The development process highlights design challenges for sustained co-creation and the leveraging of household creativity in (co-creation) research toolkits. These include the need to allow and inspire iterative customization, the need to accommodate changing roles within the home ecology, and the aim that such design should be inclusive for all family members (irrespective of age and technical proficiency), whilst maintaining a role and purpose in the home. We invite the RTD community to critically discuss our, and other, open and iterative end-user designs for sustained co-creation. By presenting unbuilt and interactive pre-built Domestic Widgets, we interactively foster engagement with practises of sustained co-creation

Spomenik: resurrecting voices in the woods

Spomenik (‘monument) is a digital memorial architecture that transposes in time otherwise hidden cultural memories of atrocity. Spomenik was designed as a simple digital audio guide, embedded in a remote rural location (Kočevski Rog, Slovenia), and working without the infrastructure normally present at national memorial sites. By resurrecting voices and cultural narratives of the deceased, positing them back in to the landscape through digital means, Spomenik opens a dialogue about the events of the past, in relation to networks of the living, exploring the role of voice and agency, as serviced through design in the act of memorialization. We contribute a detailed case study of a design-led inquiry about digital memorialization and digital preservation of cultural heritage, and a reflective account about the nature of legacy and the extent to which it is (and perhaps should be) necessarily bound to networks of collective memory, mediated through designed cultural tools