149 research outputs found
Haemoglobin scavenging after subarachnoid haemorrhage
Rapid and effective clearance of cell-free haemoglobin after subarachnoid haemorrhage (SAH) is important to prevent vasospasm and neurotoxicity and improve long-term outcome. Haemoglobin is avidly bound by haptoglobin, and the complex is cleared by CD163 expressed on the membrane surface of macrophages. We studied the kinetics of haemoglobin and haptoglobin in cerebrospinal fluid after SAH. We show that haemoglobin levels rise gradually after SAH. Haptoglobin levels rise acutely with aneurysmal rupture as a result of injection of blood into the subarachnoid space. Although levels decline as haemoglobin scavenging occurs, complete depletion of haptoglobin does not occur and levels start rising again, indicating saturation of CD163 sites available for haptoglobin-haemoglobin clearance. In a preliminary neuropathological study we demonstrate that meningeal CD163 expression is upregulated after SAH, in keeping with a proinflammatory state. However, loss of CD163 occurs in meningeal areas with overlying blood compared with areas without overlying blood. Becauses ADAM17 is the enzyme responsible for shedding membrane-bound CD163, its inhibition may be a potential therapeutic strategy after SAH
An Extension for Direct Gauge Mediation of Metastable Supersymmetry Breaking
We study the direct mediation of metastable supersymmetry breaking by a
\Phi^2-deformation to the ISS model and extend it by splitting both Tr\Phi and
Tr\Phi^2 terms in the superpotential and gauging the flavor symmetry. We find
that with such an extension the enough long-lived metastable vacua can be
obtained and the proper gaugino masses can be generated. Also, this allows for
constructing a kind of models which can avoid the Landau pole problem.
Especially, in our metastable vacua there exist a large region for the
parameter m_3 which can satisfy the phenomenology requirements and allow for a
low SUSY breaking scale (\sim 100 TeV).Comment: version in Europhys. Let
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Molecular bases and photobiological consequences of light intensity adaptation in photosynthetic organisms
By applying a combination of light transitions, uncouplers, and inhibitors of photosynthetic electron transport inhibitors we modulate the redox poise of many components in the plastid and examine the pattern of expression of cab1 gene. This gene encodes the major light harvesting protein that services photosystem II. While our results have confirmed our own previous finding that light intensity regulation of cab1 gene expression is signaled by the redox state of the PQ pool, we have also identified additional sensor(s) located in the PET chain
Instanton test of non-supersymmetric deformations of the AdS_5 x S^5
We consider instanton effects in a non-supersymmetric gauge theory obtained
by marginal deformations of the N=4 SYM. This gauge theory is expected to be
dual to type IIB string theory on the AdS_5 times deformed-S^5 background. From
an instanton calculation in the deformed gauge theory we extract the prediction
for the dilaton-axion field \tau in dual string theory. In the limit of small
deformations where the supergravity regime is valid, our instanton result
reproduces the expression for \tau of the supergravity solution found by
Frolov.Comment: 15 page
Yangians in Deformed Super Yang-Mills Theories
We discuss the integrability structure of deformed, four-dimensional N=4
super Yang-Mills theories using Yangians. We employ a recent procedure by
Beisert and Roiban that generalizes the beta deformation of Lunin and Maldacena
to produce N=1 superconformal gauge theories, which have the superalgebra
SU(2,2|1)xU(1)xU(1). The deformed theories, including those with the more
general twist, were shown to have retained their integrable structure. Here we
examine the Yangian algebra of these deformed theories. In a five field
subsector, we compute the two cases of SU(2)xU(1)xU(1)xU(1) and
SU(2|1)xU(1)xU(1) as residual symmetries of SU(2,2|1)xU(1)xU(1). We compute a
twisted coproduct for these theories, and show that only for the residual
symmetry do we retain the standard coproduct. The twisted coproduct thus
provides a method for symmetry breaking. However, the full Yangian structure of
SU(2|3) is manifest in our subsector, albeit with twisted coproducts, and
provides for the integrability of the theory.Comment: 17 page
Giants On Deformed Backgrounds
We study giant graviton probes in the framework of the three--parameter
deformation of the AdS_5 x S^5 background. We examine both the case when the
brane expands in the deformed part of the geometry and the case when it blows
up into AdS. Performing a detailed analysis of small fluctuations around the
giants, the configurations turn out to be stable. Our results hold even for the
supersymmetric Lunin-Maldacena deformation.Comment: LaTex, 28 pages, uses JHEP3; v2: minor corrections, references added;
v3: final version accepted for publication in JHE
Recommended conventions for reporting results from direct dark matter searches
The field of dark matter detection is a highly visible and highly competitive one. In this paper, we propose recommendations for presenting dark matter direct detection results particularly suited for weak-scale dark matter searches, although we believe the spirit of the recommendations can apply more broadly to searches for other dark matter candidates, such as very light dark matter or axions. To translate experimental data into a final published result, direct detection collaborations must make a series of choices in their analysis, ranging from how to model astrophysical parameters to how to make statistical inferences based on observed data. While many collaborations follow a standard set of recommendations in some areas, for example the expected flux of dark matter particles (to a large degree based on a paper from Lewin and Smith in 1995), in other areas, particularly in statistical inference, they have taken different approaches, often from result to result by the same collaboration. We set out a number of recommendations on how to apply the now commonly used Profile Likelihood Ratio method to direct detection data. In addition, updated recommendations for the Standard Halo Model astrophysical parameters and relevant neutrino fluxes are provided. The authors of this note include members of the DAMIC, DarkSide, DARWIN, DEAP, LZ, NEWS-G, PandaX, PICO, SBC, SENSEI, SuperCDMS, and XENON collaborations, and these collaborations provided input to the recommendations laid out here. Wide-spread adoption of these recommendations will make it easier to compare and combine future dark matter results
An evaluation of alcohol attendances to an inner city emergency department before and after the introduction of the UK Licensing Act 2003
Background: The Licensing Act 2003 (The Act) was implemented on the 24th November 2005 across England and Wales. The Act allowed more flexible and longer opening hours for licensed premises. We investigated the effect of The Act on alcohol related attendances to an inner city emergency department in Birmingham, UK. \ud
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Methods: We compared the proportion and time of alcohol related emergency department attendances in one week periods in January 2005 and 2006, before and after the implementation of The Licensing Act 2003. An alcohol related attendance was defined as any attendance where there was any documentation of the patient having consumed alcohol before presenting to the emergency department, if they appeared intoxicated on examination, or if alcohol attributed to their final diagnosis. \ud
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Results: The total weekly attendances increased slightly from 1,912 in 2005 to 2,146 in 2006. There was non-significant reduction in the proportion of alcohol related attendances between 2005 (3.6%) and 2006 (2.9%). A significantly greater proportion of attendances occurred at the weekend between 18.00 and 23.59 in 2005 (61.4%) than in 2006 (17.2%). There was a corresponding significant increase in the weekend proportion of attendances occurring between 03.00 to 05.59 in 2006. \ud
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Conclusion: Our findings show that there was a change in the pattern of alcohol related attendances to the emergency department around the time of implementation of the Licensing Act 2003, which has implications for delivery of emergency department services
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