Resilience of multi-photon entanglement under losses

We analyze the resilience under photon loss of the bi-partite entanglement present in multi-photon states produced by parametric down-conversion. The quantification of the entanglement is made possible by a symmetry of the states that persists even under polarization-independent losses. We examine the approach of the states to the set of states with a positive partial transpose as losses increase, and calculate the relative entropy of entanglement. We find that some bi-partite distillable entanglement persists for arbitrarily high losses.Comment: 5 pages, 3 figures, title changed, minor typographic errors correcte

A developmental investigation of the relationship between appraisals and peer self-esteem in children experiencing peer-aggression

Transactional models of stress and coping emphasize the role played by cognitive appraisals in determining psychological adjustment (Lazarus, 1999). This proposition has been supported by research examining young people's adjustment in relation to family conflict and break-up (Grych et al., 1992). Furthermore, this literature suggests that there is a change in the relationship between appraisals and adjustment at around 10 years of age: specificity of appraisal type (e.g. threat, blame) becomes relevant to outcome after 10 years, whereas before 10 there are either no effects of appraisal on adjustment or a diffuse effect of 'negative' appraisals more generally (Jouriles et al., 2000). However, it is currently unclear whether this developmental progression can be generalized from familial- to social-stressors experienced by children and young people. The current study therefore evaluates the model within the context of a commonly experienced social childhood stressor: peer-aggression

Multi-Partite Entanglement Inequalities via Spin Vector Geometry

We introduce inequalities for multi-partite entanglement, derived from the geometry of spin vectors. The criteria are constructed iteratively from cross and dot products between the spins of individual subsystems, each of which may have arbitrary dimension. For qubit ensembles the maximum violation for our inequalities is larger than that for the Mermin-Klyshko Bell inequalities, and the maximally violating states are different from Greenberger-Horne-Zeilinger states. Our inequalities are violated by certain bound entangled states for which no Bell-type violation has yet been found.Comment: 4 pages, 2 tables, 1 figure. A truncated version is published in Physical Review Letters, volume 95 issue 18, 180402 (October 2005

Extensive structure‐activity relationship study of albicidin’s C‐terminal dipeptidic p‐aminobenzoic acid moiety

Albicidin is a recently described natural product that strongly inhibits bacterial DNA gyrase. The pronounced activity, particularly against Gram‐negative bacteria, turns it into a promising lead structure for an antibacterial drug. Hence, structure–activity relationship studies are key for the in‐depth understanding of structural features/moieties affecting gyrase inhibition, antibacterial activity and overcoming resistance. The 27 newly synthesized albicidins give profound insights into possibilities for variations of the C‐terminus. Furthermore, in the present study, a novel derivative has been identified as overcoming resistance posed by the Klebsiella‐protease AlbD. Structural modifications include, for example, azahistidine replacing the previous instable cyanoalanine as the central amino acid, as well as a triazole amide bond isostere between building blocks D and E.BMBF, 03VP00030, Validierung einer neuen antibakteriellen Wirkstoffklasse - AlbiPharmTU Berlin, Open-Access-Mittel - 201

The Association of Light Trucks and Vans with Pediatric Pedestrian Deaths

We investigated the hypothesis that relative to cars, light trucks and vans (including sports utility vehicles) are more likely to result in fatal pediatric pedestrian injury. It was further hypothesized that this increased risk is a result of head injuries. The study sample consisted of 18,117 police records of motor vehicles involved in crashes in which one or more pedestrian aged 5 to 19 years old was injured or killed. Frequencies and case fatality ratios for each vehicle body type were calculated. We conducted a logistic regression analysis with light truck or van versus car as the exposure variable and fatal / non-fatal pedestrian injury as the outcome variable. After controlling for driver age, driver gender, vehicle weight, road surface condition and presence of head injury, 5 to 19 year-olds struck by light trucks or vans were more than twice as likely to die than those struck by cars (OR = 2.3 95% CI 1.4, 3.9). For the 5 to 9 year-old age group, light trucks and vans were four times as likely to be associated with fatal injury (OR = 4.2 95 % CI 1.9, 9.5). There was an association between head injury and light trucks and vans (OR=1.2, 95% CI 1.1, 1.3). We conclude that vehicle body type characteristics play an important role in pediatric pedestrian injury severity and may offer engineering-based opportunities for injury control

Outpatient antibiotic prescription trends in the United States: A national cohort study

OBJECTIVETo characterize trends in outpatient antibiotic prescriptions in the United StatesDESIGNRetrospective ecological and temporal trend study evaluating outpatient antibiotic prescriptions from 2013 to 2015SETTINGNational administrative claims data from a pharmacy benefits manager PARTICIPANTS. Prescription pharmacy beneficiaries from Express Scripts Holding CompanyMEASUREMENTSAnnual and seasonal percent change in antibiotic prescriptionsRESULTSApproximately 98 million outpatient antibiotic prescriptions were filled by 39 million insurance beneficiaries during the 3-year study period. The most commonly prescribed antibiotics were azithromycin, amoxicillin, amoxicillin/clavulanate, ciprofloxacin, and cephalexin. No significant changes in individual or overall annual antibiotic prescribing rates were found during the study period. Significant seasonal variation was observed, with antibiotics being 42% more likely to be prescribed during February than September (peak-to-trough ratio [PTTR], 1.42; 95% confidence interval [CI], 1.39–1.61). Similar seasonal trends were found for azithromycin (PTTR, 2.46; 95% CI, 2.44–3.47), amoxicillin (PTTR, 1.52; 95% CI, 1.42–1.89), and amoxicillin/clavulanate (PTTR, 1.78; 95% CI, 1.68–2.29).CONCLUSIONSThis study demonstrates that annual national outpatient antibiotic prescribing practices remained unchanged during our study period. Furthermore, seasonal peaks in antibiotics generally used to treat viral upper respiratory tract infections remained unchanged during cold and influenza season. These results suggest that inappropriate prescribing of antibiotics remains widespread, despite the concurrent release of several guideline-based best practices intended to reduce inappropriate antibiotic consumption; however, further research linking national outpatient antibiotic prescriptions to associated medical conditions is needed to confirm these findings.Infect Control Hosp Epidemiol 2018;39:584–589</jats:sec

Do coping variables mediate the effect of social identity on psychological wellbeing for bullied children?

Prsentation examining how coping variables mediate the effect of social identity on psychological wellbeing for bullied children. Demonstrates a need to understand how children interpret their situation, not just how they cope with it. This is independent of minority/majority ethnic status

Importance of site of infection and antibiotic selection in the treatment of carbapenem-resistant Pseudomonas aeruginosa sepsis

ABSTRACT In a retrospective analysis of 215 patients with carbapenem-resistant Pseudomonas aeruginosa sepsis, we observed a significantly higher risk of mortality associated with respiratory tract infection (risk ratio [RR], 1.20; 95% confidence interval [CI], 1.04 to 1.39; P = 0.010) and lower risk with urinary tract infection (RR, 0.80; 95% CI, 0.71 to 0.90; P = 0.004). Aminoglycoside monotherapy was associated with increased mortality, even after adjusting for confounders (adjusted RR, 1.72; 95% CI, 1.03 to 2.85; P = 0.037), consistent across multiple sites of infection. </jats:p

Addressing the Risks That Trade Secret Protections Pose for Health and Rights

Human rights frameworks afford everyone the right to health and the right to enjoy the benefits of scientific progress and its applications. Both come together to create state obligations to ensure access to medicines and other health technologies. Though the impact of patents on access to high-quality; affordable medicines and health technologies has been well described; there has been little attention to the impact of trade secrecy law in this context. In this paper; we describe how trade secrecy protection comes into conflict with access to medicines—for example; by preventing researchers from accessing clinical trial data; undermining the scale-up of manufacturing in pandemics; and deterring whistleblowers from reporting industry misconduct. The paper proposes measures to diminish the conflict between trade secrecy and health that are consistent with international law and will advance health without undermining innovation