Rapporto 2007 su consumo e dipendenze da sostanze in Emilia-Romagna.

Report on the state of legal and illegal substances use in the territory of Emilia-Romagna Region.Il report analizza il fenomeno delle dipendenze nel territorio della Regione Emilia-Romagna. La descrizione del fenomeno si sviluppa intorno all\u27analisi degli indicatori individuati dall\u27Osservatorio Europeo delle Dipendenze di Lisbona (OEDT): 1-uso di sostanze nella popolazione generale (questo indicatore va a rilevare i comportamenti nei confronti di alcol e sostanze psicoattive da parte della popolazione generale); 2-prevalenza d\u27uso problematico delle sostanze psicoattive; 3-domanda di trattamento degli utilizzatori di sostanze; 4-mortalit? degli utilizzatori di sostanze; 5-malattie infettive. Altri due importanti indicatori che si stanno sviluppando, e che vengono qui illustrati, sono l\u27analisi delle Schede di Dimissione Ospedaliera (SDO) e gli indicatori relativi alle conseguenza sociali dell\u27uso di droghe (criminalit? droga correlata). Inoltre sono state applicate diverse metodologie standard di stima sia per quantificare la quota parte sconosciuta di utilizzatori di sostanze che non afferiscono ai servizi, sia per identificarne alcune caratteristiche

Behaviors of Zeolite L and Brooker\u27s Merocyanine

Zeolites have a versatile role in industry as purification devices, catalysts, and ion exchange micro-vessels. Thus, understanding the behaviors of porous Zeolite L and how it interacts with molecules has become increasingly significant. In order to study the behavior Zeolite L, Brooker\u27s merocyanine was chosen for its interesting properties that can be affected by the channels of Zeolite L. This organic dye is a zwitterionic molecule with second harmonic generation potential, thermochromic and solvatochromic properties. This study focused on the behaviors of Brooker\u27s merocyanine in and around Zeolite L. Zeolite L crystals were generated through hydrothermal synthesis using a high pressure apparatus. X-ray diffraction was used to confirm the identity of the crystalline product. Then, dye loading occurred by soaking the crystals in an acidic dye solution. UV/Vis photospectroscopy was used to determine how much dye adsorbed to the zeolite. BET analysis was used to determine the location of the dye molecules on the crystals. These results showed that the dye did adsorbed to Zeolite L, but only on the surface of the crystals. Consequently, solvent studies were performed to find the optimal choice of solvent for dye loading, such as alcohols and other common solvents. Many small organic solvents, such as methanol, were tested in the solvent study. The solvent study suggested that water was not the best solvent for dye loading and rather, it was a small organic solvent. Overall, this study has developed a better understanding of the interactions between Zeolite L and Brooker\u27s merocyanine

Sylvie Freyermuth, Jean-François P. Bonnot, Des personnages et des hommes dans la ville. Géographies littéraires et sociales

Au sein des nombreuses publications ou manifestations scientifiques consacrées ces dernières années à la ville, en littérature comme en sociologie, l’ouvrage coécrit par Sylvie Freyermuth et Jean-François P. Bonnot se distingue par son approche pluridisciplinaire, mais aussi par la nature et l’ampleur du corpus étudié. Œuvres littéraires, traités de géographie, manuels d’histoire, extraits de journaux, textes philosophiques et films constituent le cœur du corpus, dans un contexte principaleme..

Characterizing the Antimicrobial and Anticancer Activities and Several Associated Bioactive Compounds of Argemone mexicana

Commonly called the Mexican prickly poppy, Argemone mexicana is a stress-resistant member of the Papaveraceae family of plants that has been used in traditional medicine for centuries by indigenous communities in Mexico and Western parts of the USA. This plant has been used to treat a wide variety of ailments, including skin diseases and intestinal infections, with reported antimicrobial and anticancer properties. However, these properties are poorly understood, with few associated bioactive compounds yet identified. Herein, we describe the germination conditions of A. mexicana and preliminarily characterize the antimicrobial and anticancer activities of different parts (seeds, leaves, inner vs. outer roots) of the plant. We show that when comparing 1 mg of each sample normalized to background solvent alone, the A. mexicana methanol outer root and leaf extracts possess the strongest antimicrobial activity, with greatest effects against the gram-positive bacteria tested, and less activity against the gram-negative bacteria and fungi tested. Additionally, we report that when using the MTT colorimetric assay, the outer root, leaf methanol, and the seed hexane extracts have pronounced inhibitory effects against T84 human colon cancer cells. Using normal-phase column chromatography and subsequent mass spectrometry analysis of the outer root and leaf methanol fractions, we have begun to chemically characterize several candidate antibacterial compounds. These preliminary results warrant further research into defining the bioactive chemicals produced in the roots, leaves and seeds of A. mexicana and are especially significant given the growing global concern of antibiotic-resistant ‘superbugs’ and lack of new antimicrobial and anticancer drug discovery

Characterizing the Antimicrobial and Anticancer Activities and Several Associated Bioactive Compounds of Argemone mexicana

Commonly called the Mexican prickly poppy, Argemone mexicana is a stress-resistant member of the Papaveraceae family of plants that has been used in traditional medicine for centuries by indigenous communities in Mexico and Western parts of the USA. This plant has been used to treat a wide variety of ailments, including skin diseases and intestinal infections, with reported antimicrobial and anticancer properties. However, these properties are poorly understood, with few associated bioactive compounds yet identified. Herein, we describe the germination conditions of A. mexicana and preliminarily characterize the antimicrobial and anticancer activities of different parts (seeds, leaves, inner vs. outer roots) of the plant. We show that when comparing 1 mg of each sample normalized to background solvent alone, the A. mexicana methanol outer root and leaf extracts possess the strongest antimicrobial activity, with greatest effects against the gram-positive bacteria tested, and less activity against the gram-negative bacteria and fungi tested. Additionally, we report that when using the MTT colorimetric assay, the outer root, leaf methanol, and the seed hexane extracts have pronounced inhibitory effects against T84 human colon cancer cells. Using normal-phase column chromatography and subsequent mass spectrometry analysis of the outer root and leaf methanol fractions, we have begun to chemically characterize several candidate antibacterial compounds. These preliminary results warrant further research into defining the bioactive chemicals produced in the roots, leaves and seeds of A. mexicana and are especially significant given the growing global concern of antibiotic-resistant ‘superbugs’ and lack of new antimicrobial and anticancer drug discovery

Ernia diaframmatica nell'ELBW: quando operare?

no abstrac

Studio di coorte sull’incidenza dei decubiti al calcagno in pazienti immobilizzati da gesso agli arti inferiori presso l’Istituto Ortopedico Rizzoli e dei possibili fattori di rischio

Introduzione. La lesione da decubito, in particolare al calcagno, può rappresentare una complicanza da immobilizzazione per apparecchio gessato. Obiettivo. Indagare l’incidenza delle complicanze cutanee tardive (in particolare la lesione da decubito al calcagno) da apparecchio gessato e valutare eventuali fattori di rischio. Materiali e metodi. Sono stati monitorati per 16 mesi tutti i pazienti consecutivi, provenienti da tre reparti, a cui veniva applicato un apparecchio gessato agli arti inferiori. I fattori di rischio sono stati identificati dall’infermiere addetto al confezionamento del gesso e la gravità della lesione stadiata con la scala NPUAP, al momento dell’asportazione del gesso, dall’infermiere del reparto o dell’ambulatorio. Risultati. Sono stati arruolati 216 pazienti. Il 17.6% (38/216) ha avuto una lesione da decubito: 16/124 (13%) nei reparti ortopedici e 22/92 (24%) nei reparti oncologici. Sono risultati fattori di rischio all’analisi multivariata, l’essere sottoposti a trattamenti con farmaci antiblastici (p=0.033; OR=2.61) (la sola patologia oncologica non aumentava il rischio rispetto alla popolazione ortopedica generale); l’avere la cute arrossata prima dell’applicazione dell’apparecchio gessato (p=0.001; OR=4.44) e l’avere accusato disturbi dopo l’applicazione (p=0.000; OR=7.86). Le lesioni erano prevalentemente di 1° grado e solo il 2.4% (6/216) erano di II grado o superiore. L’estensione e la durata del gesso, il materiale con cui viene confezionato, e l’aver subito un intervento chirurgico non sono risultati fattori di rischio statisticamente significativi. Conclusioni. Le lesioni da decubito da gesso sono una complicanza relativamente frequente in particolare in alcune popolazioni a rischio che devono tenere immobilizzati gli arti inferiori. La conoscenza del rischio di base e l’identificazione di specifici fattori di rischio possono permettere l’identificazione e lo studio di misure preventive per migliorare l’assistenza a questa specifica popolazione

The Lesson of the First Italian Lockdown: which Impacts on Anxiety and Depressive Symptoms and Sleep Quality in Patients with Remission Inflammatory Bowel Disease

Background: During the COVID-19 pandemic in Italy, decisions were taken adopting restrictive legislative measures, such as the first half of 2020 lockdown. In those months, patients with inflammatory bowel disease have experienced social isolation and reduced access to health care. Objective: Our aim was to evaluate, in this condition, the presence of remission subgroups that were most impacted by the lockdown. Methods: In the midst of the first Italian lockdown, we recruited patients with remission inflammatory bowel disease administering an online questionnaire including patient demographics, the Beck Anxiety questionnaire Inventory, the Beck Depression Inventory questionnaire and the Pittsburg Sleep Quality Index, all validated standardized questionnaires for anxiety symptom levels, depression and sleep quality. Results: Our results showed how female patients (p<0.0001) with Crohn's disease (p<0.001) experienced worse levels of anxiety symptoms. Female patients (p<0.0001), between 50 and 60 years of age (p=0.013) and with Crohn's disease (p=0.047) experienced worse levels of depressive symptoms. Females experienced significantly worse sleep levels (p<0.001). We found a correlation between the number of sleeping hours (p<0.001) and the time taken to fall asleep (p<0.001) and the Beck Anxiety questionnaire Inventory with a linear worsening of the number of minutes taken to sleep as well as with the Beck Depression Inventory questionnaire. Conclusion: Among patients with inflammatory bowel disease in remission, female patients, patients with Crohn's disease, and aged between 50 and 70 years should be considered for screening for anxiety and depression disorders and for an assessment of sleep quality