63 research outputs found
Astrocytic Mechanisms Explaining Neural-Activity-Induced Shrinkage of Extraneuronal Space
Neuronal stimulation causes ∼30% shrinkage of the extracellular space (ECS) between neurons and surrounding astrocytes in grey and white matter under experimental conditions. Despite its possible implications for a proper understanding of basic aspects of potassium clearance and astrocyte function, the phenomenon remains unexplained. Here we present a dynamic model that accounts for current experimental data related to the shrinkage phenomenon in wild-type as well as in gene knockout individuals. We find that neuronal release of potassium and uptake of sodium during stimulation, astrocyte uptake of potassium, sodium, and chloride in passive channels, action of the Na/K/ATPase pump, and osmotically driven transport of water through the astrocyte membrane together seem sufficient for generating ECS shrinkage as such. However, when taking into account ECS and astrocyte ion concentrations observed in connection with neuronal stimulation, the actions of the Na+/K+/Cl− (NKCC1) and the Na+/HCO3− (NBC) cotransporters appear to be critical determinants for achieving observed quantitative levels of ECS shrinkage. Considering the current state of knowledge, the model framework appears sufficiently detailed and constrained to guide future key experiments and pave the way for more comprehensive astroglia–neuron interaction models for normal as well as pathophysiological situations
Effects of reduced pH on shell integrity of a common whelk from a natural undersea CO2 vent community off Vulcano Island, Italy.
Hexaplex trunculus is a widespread Mediterranean gastropod mollusc that plays a crucial role in benthic ecosystem dynamics. Individuals occur in shallow, sublittoral habitats near Vulcano Island, Italy, where an undersea CO2 vent provides a gradient of seawater acidification mimicing future predicted levels of ocean acidification. Individuals were collected from three sites with declining pH [ambient ( pH 8.18), medium (pH 8.05) and low (pH 7.49)]. Dissolution of shells was clearly evident at the medium (smoothing of outer shell ) and low (pitting and holes) pH sites. Scanning electron microcroscopy will provide a qualitative comparative assessment of micro-scale impacts of shell dissolution of individuals from the three sites. X-ray diffraction will provide a quantitative comparative assessment of carbonate composition in shells of individuals from the three pH sites. This study indicates that end of century anticipated levels of ocean acidification are capable of causing severe shell damage that may render individuals more susceptible to infection and predation
Effects of reduced pH on shell mineral composition and integrity of three common gastropods from a natural undersea CO2 vent community off Vulcano Island, Italy
Evidence summary: does dentists' fear have an adverse effect on clinical decision-making?
Scale Dependence of Female Ungulate Reproductive Success in Relation to Nutritional Condition, Resource Selection and Multi-Predator Avoidance
Anti-inflammatory effects of retinoids and carotenoid derivatives on caspase-3–dependent apoptosis and efferocytosis of bovine neutrophils
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