Patterns of Influenza Vaccination Coverage in the United States from 2009 to 2015

Background: Globally, influenza is a major cause of morbidity, hospitalization and mortality. Influenza vaccination has shown substantial protective effectiveness in the United States. We investigated state-level patterns of coverage rates of seasonal and pandemic influenza vaccination, among the overall population in the U.S. and specifically among children and the elderly, from 2009/10 to 2014/15, and associations with ecological factors. Methods and Findings: We obtained state-level influenza vaccination coverage rates from national surveys, and state-level socio-demographic and health data from a variety of sources. We employed a retrospective ecological study design, and used mixed-model regression to determine the levels of ecological association of the state-level vaccinations rates with these factors, both with and without region as a factor for the three populations. We found that health-care access is positively and significantly associated with mean influenza vaccination coverage rates across all populations and models. We also found that prevalence of asthma in adults are negatively and significantly associated with mean influenza vaccination coverage rates in the elderly populations. Conclusions: Health-care access has a robust, positive association with state-level vaccination rates across different populations. This highlights a potential population-level advantage of expanding health-care access.Comment: 10 pages, 2 figure

Neural Generalized Ordinary Differential Equations with Layer-varying Parameters

Deep residual networks (ResNets) have shown state-of-the-art performance in various real-world applications. Recently, the ResNets model was reparameterized and interpreted as solutions to a continuous ordinary differential equation or Neural-ODE model. In this study, we propose a neural generalized ordinary differential equation (Neural-GODE) model with layer-varying parameters to further extend the Neural-ODE to approximate the discrete ResNets. Specifically, we use nonparametric B-spline functions to parameterize the Neural-GODE so that the trade-off between the model complexity and computational efficiency can be easily balanced. It is demonstrated that ResNets and Neural-ODE models are special cases of the proposed Neural-GODE model. Based on two benchmark datasets, MNIST and CIFAR-10, we show that the layer-varying Neural-GODE is more flexible and general than the standard Neural-ODE. Furthermore, the Neural-GODE enjoys the computational and memory benefits while performing comparably to ResNets in prediction accuracy

Contagion Source Detection in Epidemic and Infodemic Outbreaks: Mathematical Analysis and Network Algorithms

This monograph provides an overview of the mathematical theories and computational algorithm design for contagion source detection in large networks. By leveraging network centrality as a tool for statistical inference, we can accurately identify the source of contagions, trace their spread, and predict future trajectories. This approach provides fundamental insights into surveillance capability and asymptotic behavior of contagion spreading in networks. Mathematical theory and computational algorithms are vital to understanding contagion dynamics, improving surveillance capabilities, and developing effective strategies to prevent the spread of infectious diseases and misinformation.Comment: Suggested Citation: Chee Wei Tan and Pei-Duo Yu (2023), "Contagion Source Detection in Epidemic and Infodemic Outbreaks: Mathematical Analysis and Network Algorithms", Foundations and Trends in Networking: Vol. 13: No. 2-3, pp 107-251. http://dx.doi.org/10.1561/130000006

A High-Performance Triple Patterning Layout Decomposer with Balanced Density

Triple patterning lithography (TPL) has received more and more attentions from industry as one of the leading candidate for 14nm/11nm nodes. In this paper, we propose a high performance layout decomposer for TPL. Density balancing is seamlessly integrated into all key steps in our TPL layout decomposition, including density-balanced semi-definite programming (SDP), density-based mapping, and density-balanced graph simplification. Our new TPL decomposer can obtain high performance even compared to previous state-of-the-art layout decomposers which are not balanced-density aware, e.g., by Yu et al. (ICCAD'11), Fang et al. (DAC'12), and Kuang et al. (DAC'13). Furthermore, the balanced-density version of our decomposer can provide more balanced density which leads to less edge placement error (EPE), while the conflict and stitch numbers are still very comparable to our non-balanced-density baseline