Overcoming the Divide between Freedom and Nature: Clarisse Coignet on the Metaphysics of Independent Morality

Clarisse Coignet (1823-1918) played an important role in a number of the most important intellectual movements in nineteenth-century France. She grew up around and documented the leaders of the Fourierist movement, provided the philosophical support for the La Morale indépendante (an influential movement that promoted the rebuilding of French society on the basis of free morality, rather than religion), and spent twenty years defending the secularization of education and improving French primary schools. She developed her own theoretical and practical philosophy and applied it in the social world to play her part in the transformation of her country “from more or less an absolute monarchy, into a free republic” (Coignet, 1903: 7). Despite all of this, her work has received very little philosophical attention. This article focuses on the theoretical underpinnings of her practical philosophy, and the importance of her engagement with the French spiritualist tradition for its development

Flights in the resting places: James and Bergson on mental synthesis and the experience of time

The similarities between William James’ Stream of Consciousness and Henri Bergson’s La durée réelle have often been noted. Both emphasize the fundamentally temporal nature of our conscious experience and its constant flow. However, in this article, I argue that despite surface similarities between the OP theories, they are fundamentally different. The ultimate reason for the differences between the theories is that James believed that we should reject psychological explanations that depend on synthesis within the mental sphere. This is because such explanations are incompatible with empiricism. Instead, we should look to the physiological mechanisms underpinning mental states. In contrast, Bergson was an adamant defender of a form of mental processing which he called qualitative synthesis. Duration itself, for Bergson, is a form of qualitative synthesis. However, in 1906, less than five years before James died, Bergson convinced him to change his mind. This results in a huge shift in James’ thought. Unless we understand how far apart James and Bergson were prior to this shift, we will not have a proper picture of the full influence of Bergson on James’ thought, nor of the major changes to James’ philosophy that occurred near the end of his life

Understanding Early Diagenetic Silicification: Petrographic Fabrics within Proterozoic Microfossiliferous Chert

Early diagenetic chert is abundant in Proterozoic carbonate successions and provides a critical window into organic preservation; the depositional origin of this chert, however, remains uncertain. There have been relatively few detailed petrographic analyses of Proterozoic microfossiliferous chert, which limits our understanding of both primary depositional fabrics, and of petrographic change during post-depositional recrystallization. The ~1.1 Ga Angmaat Formation, northern Baffin Island, Canada, contains abundant early diagenetic chert that contains exquisitely preserved microbial assemblages. Petrographic analysis indicates that chert is composed of four primary phases: chalcedony spherules that replace the majority of primary microbial and sedimentary elements, equigranular microcrystalline quartz which occurs as a minor component in the groundmass, chalcedony that lines primary voids within the depositional fabric, and megaquartz that occurs within chalcedony-lined voids. Here we present a detailed petrographic characterization of chert within the Angmaat Formation to better understand the mechanism of formation and potential pathway of diagenesis. Observations suggest that the silicification process began with formation of a silica gel within benthic microbial mats and associated carbonate sediment. We suggest that gel formation was intimately associated with the presence of organic matter (e.g., microbes and associated EPS), and that constructional voids (e.g., gas bubbles) within the mat remained free of silica gel. Polymeric linkages within the gel phase appear to have provided sufficient structure for precipitation of spherules as opal-CT, rather than as opal-A, thus resulting in minimal water loss associated with post-depositional recrystallization to chalcedony which favored exquisite microfossil preservation

Long-period ocean sound waves constrain shallow slip and tsunamis in megathrust ruptures

Great earthquakes along subduction-zone plate boundaries, like the magnitude 9.0 Tohoku-Oki, Japan, event, deform the seafloor to generate massive tsunamis. Tsunami wave heights near shore are greatest when excitation occurs far offshore near the trench, where water depths are greatest and fault slip is shallow. Unfortunately the rupture process there is poorly constrained with land-based geodetic and even seafloor deformation measurements. Here we demonstrate, through dynamic rupture simulations of the Tohoku event, that long-period sound waves in the ocean, observable with ocean-bottom pressure sensors and/or seismometers, can resolve the shallow rupture process and tsunami excitation near the trench. These waves could potentially be used to improve local tsunami early warning systems

"Внутренняя картина болезни" и ее динамика у больных желчнокаменной болезнью

ЖЕЛЧНОКАМЕННАЯ БОЛЕЗНЬВНУТРЕННИЕ БОЛЕЗНИАСТЕНИЯКАЧЕСТВО ЖИЗНИПСИХОТЕРАПИ

Sustainability at Banorte: A Comprehensive CSR Strategy

As financial institutions approach sustainability in new ways, this report, prepared as a master's project for the School of Natural Resources and Environment, represents an innovative comprehensive corporate social responsibility strategy for the 3rd largest bank in Mexico, Grupo Financiero Banorte (Banorte). Through an extensive review of CSR literature, a compilation of best practices, and incorporation of organizational and decision-making frameworks most relevant to CSR, the report provides an overview of the year-long collaboration between Banorte and University of Michigan students from the Erb Institute for Global Sustainable Enterprise. This collaboration yielded key current and future short and long-term steps that will allow the bank to better integrate CSR (environmental, social and financial performance) into its core business strategy. In addition, the report includes two representative case studies of CSR initiatives: Small and Medium Enterprise education and Paper Reduction. Each of these studies provides key learnings and insights applicable for continued progress in creating an innovative corporate social responsibility strategy over the next three years and beyond.Master of ScienceNatural Resources and EnvironmentUniversity of Michiganhttp://deepblue.lib.umich.edu/bitstream/2027.42/83665/1/Banorte Revised SNRE V5 MM.pd

Galactic H2CO Densitometry I: Pilot survey of Ultracompact HII regions and methodology

We present a pilot survey of 21 lines of sight towards UCHII regions in the H2CO 1-1 (6cm) and 2-2 (2cm) transitions, using the H2CO centimeter lines as a molecular gas densitometer. Using Arecibo and Green Bank beam-matched observations, we measure the density of 51 detected H2CO line pairs and present upper limits on density for an additional 24 detected 1-1 lines. We analyze the systematic uncertainties in the H2CO densitometer, achieving H2 density measurements with accuracies ~ 0.1-0.3 dex. The densities measured are not correlated with distance, implying that it is possible to make accurate density measurements throughout the galaxy without a distance bias. We confirm that ultracompact HII regions are associated with gas at densities n(H2)~10^5cm^-3. The densities measured in line-of-sight molecular clouds suggest that they consist of low volume filling factor (f~10^-2) gas at high (n(H2)>10^4cm^-3) density, which is inconsistent with purely supersonic turbulence and requires high-density clumping greater than typically observed in gravoturbulent simulations. We observe complex line morphologies that indicate density variations with velocity around UCHII regions, and we classify a subset of the UCHII molecular envelopes as collapsing or expanding. We compare these measurements to Bolocam Galactic Plane Survey 1.1mm observations, and note that most UCHII regions have 1.1mm emission consisting of significant (5-70%) free-free emission and are therefore not necessarily dominated by optically thin dust emission. A comparison of our data with the Mangum et al. starburst sample shows that the area filling factor of dense (n(H2)~10^5cm^-3) molecular gas in typical starburst galaxies is <~0.01, but in extreme starburst galaxies like Arp 220, is ~0.1, suggesting that Arp 220 is physically similar to an oversized UCHII region.Comment: 39 pages, 46 figures, 8 tables, EmulateApJ 2-column format. Accepted for publication in ApJ. Full resolution version: http://casa.colorado.edu/~ginsbura/papers/h2co_pilot_draft0607.pdf, published at http://stacks.iop.org/0004-637X/736/14

The effect of natural organic matter on the adsorption of mercury to bacterial cells

We investigated the ability of non-metabolizing Bacillus subtilis, Shewanella oneidensis MR-1, and Geobacter sulfurreducens bacterial species to adsorb mercury in the absence and presence of Suwanee River fulvic acid (FA). Bulk adsorption and X-ray absorption spectroscopy (XAS) experiments were conducted at three pH conditions, and the results indicate that the presence of FA decreases the extent of Hg adsorption to biomass under all of the pH conditions studied. Hg XAS results show that the presence of FA does not alter the binding environment of Hg adsorbed onto the biomass regardless of pH or FA concentration, indicating that ternary bacteria–Hg–FA complexes do not form to an appreciable extent under the experimental conditions, and that Hg binding on the bacteria is dominated by sulfhydryl binding. We used the experimental results to calculate apparent partition coefficients, Kd, for Hg under each experimental condition. The calculations yield similar coefficients for Hg onto each of the bacterial species studies, suggesting there is no significant difference in Hg partitioning between the three bacterial species. The calculations also indicate similar coefficients for Hg–bacteria and Hg–FA complexes. S XAS measurements confirm the presence of sulfhydryl sites on both the FA and bacterial cells, and demonstrate the presence of a wide range of S moieties on the FA in contrast to the bacterial biomass, whose S sites are dominated by thiols. Our results suggest that although FA can compete with bacterial binding sites for aqueous Hg, because of the relatively similar partition coefficients for the types of sorbents, the competition is not dominated by either bacteria or FA unless the concentration of one type of site greatly exceeds that of the other

Integrative GWAS and co-localisation analysis suggests novel genes associated with age-related multimorbidity

Abstract Advancing age is the greatest risk factor for developing multiple age-related diseases. Therapeutic approaches targeting the underlying pathways of ageing, rather than individual diseases, may be an effective way to treat and prevent age-related morbidity while reducing the burden of polypharmacy. We harness the Open Targets Genetics Portal to perform a systematic analysis of nearly 1,400 genome-wide association studies (GWAS) mapped to 34 age-related diseases and traits, identifying genetic signals that are shared between two or more of these traits. Using locus-to-gene (L2G) mapping, we identify 995 targets with shared genetic links to age-related diseases and traits, which are enriched in mechanisms of ageing and include known ageing and longevity-related genes. Of these 995 genes, 128 are the target of an approved or investigational drug, 526 have experimental evidence of binding pockets or are predicted to be tractable, and 341 have no existing tractability evidence, representing underexplored genes which may reveal novel biological insights and therapeutic opportunities. We present these candidate targets for exploration and prioritisation in a web application

Multi-ancestry Mendelian randomization of omics traits revealing drug targets of COVID-19 severity

BACKGROUND: Recent omic studies prioritised several drug targets associated with coronavirus disease 2019 (COVID-19) severity. However, little evidence was provided to systematically estimate the effect of drug targets on COVID-19 severity in multiple ancestries. METHODS: In this study, we applied Mendelian randomization (MR) and colocalization approaches to understand the putative causal effects of 16,059 transcripts and 1608 proteins on COVID-19 severity in European and effects of 610 proteins on COVID-19 severity in African ancestry. We further integrated genetics, clinical and literature evidence to prioritise drug targets. Additional sensitivity analyses including multi-trait colocalization and phenome-wide MR were conducted to test for MR assumptions. FINDINGS: MR and colocalization prioritized four protein targets, FCRL3, ICAM5, ENTPD5 and OAS1 that showed effect on COVID-19 severity in European ancestry. One protein target, SERPINA1 showed a stronger effect in African ancestry but much weaker effect in European ancestry (odds ratio [OR] in Africans=0.369, 95%CI=0.203 to 0.668, P = 9.96 × 10(−4); OR in Europeans=1.021, 95%CI=0.901 to 1.157, P = 0.745), which suggested that increased level of SERPINA1 will reduce COVID-19 risk in African ancestry. One protein, ICAM1 showed suggestive effect on COVID-19 severity in both ancestries (OR in Europeans=1.152, 95%CI=1.063 to 1.249, P = 5.94 × 10(−4); OR in Africans=1.481, 95%CI=1.008 to 2.176; P = 0.045). The OAS1, SERPINA1 and ICAM1 effects were replicated using updated COVID-19 severity data in the two ancestries respectively, where alternative splicing events in OAS1 and ICAM1 also showed marginal effects on COVID-19 severity in Europeans. The phenome-wide MR of the prioritised targets on 622 complex traits provided information on potential beneficial effects on other diseases and suggested little evidence of adverse effects on major complications. INTERPRETATION: Our study identified six proteins as showing putative causal effects on COVID-19 severity. OAS1 and SERPINA1 were targets of existing drugs in trials as potential COVID-19 treatments. ICAM1, ICAM5 and FCRL3 are related to the immune system. Across the six targets, OAS1 has no reliable instrument in African ancestry; SERPINA1, FCRL3, ICAM5 and ENTPD5 showed a different level of putative causal evidence in European and African ancestries, which highlights the importance of more powerful ancestry-specific GWAS and value of multi-ancestry MR in informing the effects of drug targets on COVID-19 across different populations. This study provides a first step towards clinical investigation of beneficial and adverse effects of COVID-19 drug targets. FUNDING: No