Master collaboration: technology and assessment: research gaps, best practices, and future agenda

This session will review current research on the assessment center method. Topics will include AC validity and usefulness, proper design and application of the AC method through alignment with broader talent management strategies, differences in perspectives on focal constructs, and creating ACs to meet client needs while respecting current research

Short Gamma Ray Bursts as possible electromagnetic counterpart of coalescing binary systems

Coalescing binary systems, consisting of two collapsed objects, are among the most promising sources of high frequency gravitational waves signals detectable, in principle, by ground-based interferometers. Binary systems of Neutron Star or Black Hole/Neutron Star mergers should also give rise to short Gamma Ray Bursts, a subclass of Gamma Ray Bursts. Short-hard-Gamma Ray Bursts might thus provide a powerful way to infer the merger rate of two-collapsed object binaries. Under the hypothesis that most short Gamma Ray Bursts originate from binaries of Neutron Star or Black Hole/Neutron Star mergers, we outline here the possibility to associate short Gamma Ray Bursts as electromagnetic counterpart of coalescing binary systems.Comment: 4 pages, 1 figur

Visual and cognitive deficits predict stopping or restricting driving: The salisbury eye evaluation driving study (SEEDS)

PURPOSE. To determine the visual and other factors that predict stopping or restricting driving in older drivers. METHODS. A group of 1425 licensed drivers aged 67 to 87 years, who were residents of greater Salisbury, participated. At 1 year after enrollment, this group was categorized into those who had stopped driving, drove only within their neighborhood, or continued to drive beyond their neighborhood. At baseline, a battery of structured questionnaires, vision, and cognitive tests were administered. Multivariate analysis determined the factors predictive of stopping or restricting driving 12 months later. RESULTS. Of the 1425 enrolled, 1237 (87%) were followed up at 1 year. Excluding those who were already limiting their driving at baseline (n = 35), 1.5% (18/1202) had stopped and 3.4% (41/1202) had restricted their driving. The women (odds ratio [OR], 4.01; 95% confidence interval [CI], 2.05- 8.20) and those who prefer to be driven (OR, 3.91; 95% CI, 1.91- 8.00) were more likely to stop or restrict driving. Depressive symptoms increased likelihood of restricting or stopping driving (OR, 1.08; 95% CI, 1.009 -1.16 per point Geriatric Depression Scale). Slow visual scanning and psychomotor speed (Trail Making Test, Part A: OR, 1.02; 95% CI, 1.01-1.03), poor visuoconstructional skills (Beery-Buktenica Test of Visual Motor Integration: OR, 1.14; 95% CI, 1.05-1.25), and reduced contrast sensitivity (OR, 1.15; 95% CI, 1.03-1.28) predicted stopping or reducing driving. Visual field loss and visual attention were not associated. The effect of vision on changing driving behavior was partially mediated by cognition, depression, and baseline driving preferences. CONCLUSIONS. In this cohort, contrast sensitivity and cognitive function were independently associated with incident cessation or restriction of driving space. These data suggest drivers with functional deficits make difficult decisions to restrict or stop driving

An Adeno-Associated Viral Vector Capable of Penetrating the Mucus Barrier to Inhaled Gene Therapy

Diffusion of the viral vectors evaluated in inhaled gene therapy clinical trials to date are largely hindered within airway mucus, which limits their access to, and transduction of, the underlying airway epithelium prior to clearance from the lung. Here, we discovered that adeno-associated virus (AAV) serotype 6 was able to rapidly diffuse through mucus collected from cystic fibrosis (CF) patients, unlike previously tested AAV serotypes. A point mutation of the AAV6 capsid suggests a potential mechanism by which AAV6 avoids adhesion to the mucus mesh. Significantly greater transgene expression was achieved with AAV6 compared to a mucoadhesive serotype, AAV1, in air-liquid interface cultures of human CF bronchial epithelium with naturally secreted mucus or induced mucus hypersecretion. In addition, AAV6 achieved superior distribution and overall level of transgene expression compared to AAV1 in the airways and whole lungs, respectively, of transgenic mice with airway mucus obstruction. Our findings motivate further evaluation and clinical development of AAV6 for inhaled gene therapy

Coherent π0 photoproduction on the deuteron up to 4 GeV

The differential cross section for 2H(γ,d)π0 has been measured at deuteron center-of-mass angles of 90° and 136°. This work reports the first data for this reaction above a photon energy of 1 GeV, and permits a test of the apparent constituent counting rule and reduced nuclear amplitude behavior as observed in elastic ed scattering. Measurements were performed up to a photon energy of 4.0 GeV, and are in good agreement with previous lower energy measurements. Overall, the data are inconsistent with both constituent-counting rule and reduced nuclear amplitude predictions

Nitric oxide releasing-dendrimers: an overview

Platforms able to storage, release or scavenge NO in a controlled and specific manner is interesting for biological applications. Among the possible matrices for these purposes, dendrimers are excellent candidates for that. These molecules have been used as drug delivery systems and exhibit interesting properties, like the possibility to perform chemical modifications on dendrimers surface, the capacity of storage high concentrations of compounds of interest in the same molecule and the ability to improve the solubility and the biocompatibility of the compounds bonded to it. This review emphasizes the recent progress in the development and in the biological applications of different NO-releasing dendrimers and the nitric oxide release pathways in these compounds

Avaliação de genótipos de arroz sob efeito do ácido butírico

Solos do tipo hidromórfico apresentam uma reduzida capacidade de drenagem, sendo utilizados principalmente para cultivo de arroz irrigado. Esta condição favorece o desenvolvimento de microrganismos anaeróbios que produzem substâncias fitotóxicas. O objetivo do trabalho foi avaliar a resposta de 25 genótipos de arroz ao ácido butírico, um composto produzido em solos de deficiente drenagem e alto teor de matéria orgânica. O trabalho foi executado em sistema de hidroponia com 4 doses do ácido e o delineamento utilizado foi blocos casualizados com 3 repetições em um esquema fatorial. As variáveis mensuradas foram comprimento de raízes (CR) e de parte aérea (CPA), número de raízes (NR) e matéria seca de raízes (MSR) e parte aérea (MSPA). Foram procedidas análise de variância, desempenho relativo e ajuste de regressões. Os efeitos para genótipos e doses de ácido butírico foram todos significativos. Apenas os efeitos de interação entre doses x genótipos para as variáveis CR e MSR revelaram significância. A variável CR foi a mais afetada pelo ácido e as regressões estabelecidas para essa variável revelaram 9 genótipos tolerantes e 16 sensíveis ao efeito fitototoxico do ácido butírico. Genótipos desenvolvidos para sistema de irrigação por inundação se mostraram mais tolerantes ao ácido

Searches for lepton-flavour-violating decays of the Higgs boson in s=13\sqrt{s}=13 TeV pp\mathit{pp} collisions with the ATLAS detector

This Letter presents direct searches for lepton flavour violation in Higgs boson decays, H → eτ and H → μτ , performed with the ATLAS detector at the LHC. The searches are based on a data sample of proton–proton collisions at a centre-of-mass energy √s = 13 TeV, corresponding to an integrated luminosity of 36.1 fb−1. No significant excess is observed above the expected background from Standard Model processes. The observed (median expected) 95% confidence-level upper limits on the leptonflavour-violating branching ratios are 0.47% (0.34+0.13−0.10%) and 0.28% (0.37+0.14−0.10%) for H → eτ and H → μτ , respectively.publishedVersio