Immunohistochemical pattern– a prognostic factor for synchronous gastrointestinal cancer

Recent advancements in medical genetics and molecular biology are reflected in the modern understanding and approach to colorectal carcinoma (CRC). Understanding the cellular mechanisms and mutational patterns that promote carcinogenesis could enhance the predictive accuracy of the TNM classification. Furthermore, this will allow for a much more documented stratification and tailored oncological treatment. This paper presents an illustrative case of a relatively young patient (50 years old) with no family history of cancer who was diagnosed with four synchronous gastrointestinal (GI) adenocarcinomas displaying a wild type P53, negative BRAF testing, and mutated MLH1 and PMS2 proteins. This case report contributes to the relevant literature with a concise review of the role of micro-satellite instability (MSI), chromosomal instability (CIN), and CpG island methylator phenotype (CIMP) in carcinogenesis, hereditary and sporadic gastrointestinal cancers, a discussion over the importance of molecular sub-typing in predicting long term outcomes and choosing the most suitable adjuvant treatment regimen

Pain in photodynamic therapy

Photodynamic therapy is a modern treatment with applications in several medical specialties, which has been intensely studied in the last years. The main indications in dermatology are actinic keratosis, superficial basal cell carcinoma and Bowen\u27s disease- common skin disorders in which photodynamic therapy proved its efficacy. At present, the use of photodynamic therapy for the treatment of other skin disorders is profoundly researched. Pain is the most common and redoubtable adverse effect of photodynamic therapy and it is the most important factor affecting the patient\u27s adherence to treatment. The aim of this article is to look over the most recent medical studies regarding pain in PDT, with emphasis on the factors affecting the occurrence of pain and the most recent strategies for controlling photodynamic therapy- related pain

Isolated Hybrid Solar-Wind-Hydro Renewable Energy Systems

Non

Farmed cyprinids diseases from the Prut River Basin

The current paper aims to outline the most common fish diseases that affect farmed cyprinids in ponds from the Prut river basin, in order to better understand and reduce fish health risks. After 2 field work expeditions to Rompescaris farm -Podu-Iloaiei from Iasi county and to Dracșani fish farm from Piscicola-Botoșani county, biological samples were collected, in May 2021. Using net fishing the following fish species were harvested: carp (Cyprinus carpio), silver carp (Hypophthalmichthys molitrix) and mirror carp (Cyprinus carpio var. specularis). the biological material, the moribund specimens with visible lesions were isolated and the apparently healthy specimens were released. The collected specimens were subjected to a clinical, a parasitological and a bacteriological investigation

Analysis of a hybrid renewable energy system on the Mures valley using Homer

Renewable energy technologies offer the promise of clean, abundant energy gathered from self-renewing resources such as the sun, wind, earth, and plants. Virtually all regions of the world have renewable resources of one type or another. This paper deals with the modeling and analysis of a hybrid system based on renewable energy resources, located on the Mureş valley, using a dedicated software named HOMER. Different types and topologies of renewable resources for the energy supply are analyzed; a small consumer situated on the Mureş Valley is modeled based on a load curve. Finally, the energy flows between the renewable energy system and the local supplying network are analyzed

Research on Inner Surface of Tubes Hydroformed

In this paper is presented a reserch regarding the surfece of hydroforming tubs, made by aluminium and cooper. Hydroforming tubes is very important production method considering that metal tubes are widely used in a great variety of engineering products, such as automobile, aircraft, air conditioner, air compressor, exhaust systems, fluid lines. The results show that the surface of tubes it is influence of the hydroforming process. Also it is very important the material of the tube in research of surface

3D Modeling of Mechanical Transmissions for Base Translation of an Industrial Robot

This paper presents 2 chained mechanical transmissions used to obtainthe base translation of an industrial robot: worm - worm gear transmission and motion screw - nut transmission. The kinematicalscheme, the 3D models of the main parts of the mechanicaltransmissions and the 3D assembly model are shown. For modeling,CATIA V5 software was used

Unraveling the Intricate Link: Deciphering the Role of the Golgi Apparatus in Breast Cancer Progression

Breast cancer represents a paramount global health challenge, warranting intensified exploration of the molecular underpinnings influencing its progression to facilitate the development of precise diagnostic instruments and customized therapeutic regimens. Historically, the Golgi apparatus has been acknowledged for its primary role in protein sorting and trafficking within cellular contexts. However, recent findings suggest a potential link between modifications in Golgi apparatus function and organization and the pathogenesis of breast cancer. This review delivers an exhaustive analysis of this correlation. Specifically, we examine the consequences of disrupted protein glycosylation, compromised protein transport, and inappropriate oncoprotein processing on breast cancer cell dynamics. Furthermore, we delve into the impacts of Golgi-mediated secretory routes on the release of pro-tumorigenic factors during the course of breast cancer evolution. Elucidating the nuanced interplay between the Golgi apparatus and breast cancer can pave the way for innovative therapeutic interventions and the discovery of biomarkers, potentially enhancing the diagnostic, prognostic, and therapeutic paradigms for afflicted patients. The advancement of such research could substantially expedite the realization of these objectives

Lanthanum Ferrite Ceramic Powders: Synthesis, Characterization and Electrochemical Detection Application

The perovskite-type lanthanum ferrite, LaFeO3, has been prepared by thermal decomposition of in situ obtained lanthanum ferrioxalate compound precursor, LaFe(C2O4)3·3H2O. The oxalate precursor was synthesized through the redox reaction between 1,2-ethanediol and nitrate ion and characterized by chemical analysis, infrared spectroscopy, and thermal analysis. LaFeO3 obtained after the calcination of the precursor for at least 550–800 °C/1 h have been investigated by X-ray diffraction (XRD), field emission scanning electron microscopy (FE-SEM), transmission electron microscopy (TEM), and high-resolution transmission electron microscopy (HRTEM). A boron-doped diamond electrode (BDD) modified with LaFeO3 ceramic powders at 550 °C (LaFeO3/BDD) by simple immersion was characterized by cyclic voltammetry and tested for the voltammetric and amperometric detection of capecitabine (CCB), which is a cytostatic drug considered as an emerging pollutant in water. The modified electrode exhibited a complex electrochemical behaviour by several redox systems in direct relation to the electrode potential range. The results obtained by cyclic voltammetry (CV), differential-pulsed voltammetry (DPV), and multiple-pulsed amperometry proved the electrocatalytic effect to capecitabine oxidation and reduction and allowed its electrochemical detection in alkaline aqueous solution