On the Prediction of In Vitro Arginine Glycation of Short Peptides Using Artificial Neural Networks

One of the hallmarks of diabetes is an increased modification of cellular proteins. The most prominent type of modification stems from the reaction of methylglyoxal with arginine and lysine residues, leading to structural and functional impairments of target proteins. For lysine glycation, several algorithms allow a prediction of occurrence; thus, making it possible to pinpoint likely targets. However, according to our knowledge, no approaches have been published for predicting the likelihood of arginine glycation. There are indications that arginine and not lysine is the most prominent target for the toxic dialdehyde. One of the reasons why there is no arginine glycation predictor is the limited availability of quantitative data. Here, we used a recently published high–quality dataset of arginine modification probabilities to employ an artificial neural network strategy. Despite the limited data availability, our results achieve an accuracy of about 75% of correctly predicting the exact value of the glycation probability of an arginine–containing peptide without setting thresholds upon whether it is decided if a given arginine is modified or not. This contribution suggests a solution for predicting arginine glycation of short peptides

A Climate-Mathematical Clustering of Rainfall Stations in the Río Bravo-San Juan Basin (Mexico) by Using the Higuchi Fractal Dimension and the Hurst Exponent

When conducting an analysis of nature’s time series, such as meteorological ones, an important matter is a long-range dependence to quantify the global behavior of the series and connect it with other physical characteristics of the region of study. In this paper, we applied the Higuchi fractal dimension and the Hurst exponent (rescaled range) to quantify the relative trend underlying the time series of historical data from 17 of the 34 weather stations located in the Río Bravo-San Juan Basin, Mexico; these data were provided by the National Water Commission CONAGUA) in Mexico. In this way, this work aims to perform a comparative study about the level of persistency obtained by using the Higuchi fractal dimension and Hurst exponent for each station of the basin. The comparison is supported by a climate clustering of the stations, according to the Köppen classification. Results showed a better fitting between the climate of each station and its Higuchi fractal dimension obtained than when using the Hurst exponent. In fact, we found that the more the aridity of the zone the more the persistency of rainfall, according to Higuchi’s values. In turn, we found more relation between the Hurst exponent and the accumulated amount of rainfall. These are relations between the climate and the long-term persistency of rainfall in the basin that could help to better understand and complete the climatological models of the study region. Trends between the fractal exponents used and the accumulated annual rainfall were also analyzed