3 research outputs found
CATALYSE INTRAMOLECULAIRE DE L'AMINOLYSE DES HETEROCYCLES PHOSPHORES DERIVES DES α AMINOAMIDES. II: ETUDE DE LA CYCLISATION DES PHOSPHORDIAMIDES INCORPORANT UN RESIDU DE β AMINOACIDE, REACTIVITE VIS A VIS DE NUCLEOPHILES DES HETEROCYCLES FORMES
No full textSynthesis and in vitro antitumor activity of ring C and D-substituted phenanthrolin-7-one derivatives, analogues of the marine pyridoacridine alkaloids ascididemin and meridine.
No full textA series of cycle C and D-substituted phenanthrolin-7-ones, analogues of the marine pyridoacridines meridine and ascididemin have been synthesized on the basis of Diels-Alder reactions involving quinoline-5,8-dione and 2- (or un)-substituted-N,N-dimethylhydrazones. All the compounds were evaluated for in vitro cytotoxic activity against 12 distinct human cancer cell lines. They all exhibit cytotoxic activity with IC(50) values at least of micromolar order.Journal Articleinfo:eu-repo/semantics/publishe
