2,615 research outputs found
Un ADL pour les Architectures Distribuées à Composants HétérogÚnes
National audienceDans cet article, nous présentons un ADL pour les architectures à composants hétérogÚnes et distribuées, et son utilisation au moment du déploiement. Actuellement, il n'existe pas de solution générique pour déployer une architecture distribuée basée sur différents intergiciels. Pour répondre à cette problématique, nous proposons dans cet article une approche pour décrire une telle architecture et un support pour le déploiement. Notre solution s'appuie sur un langage de description d'architecture possédant des notions de dépendances verticales et horizontales. Un exemple simple est présenté pour illustrer notre langage et pour valider nos contributions
Quelle histoire de la sculpture au XXe siÚcle ?
Les livraisons de lâannĂ©e 2002 confirment lâintĂ©rĂȘt soutenu pour les Ă©tudes sur la sculpture. Du point de vue de la consolidation de la connaissance, on dispose dĂ©sormais dâun beau catalogue raisonnĂ© de lâĆuvre sculptĂ© de Fenosa (1899-1988), protĂ©gĂ© de Picasso et Cocteau, auteur de la TempĂȘte pourchassĂ©e par le beau temps (1957) placĂ©e boulevard Saint-Jacques Ă Paris en 1978-1979 et du Monument Ă Pau Casals (1976-1977) Ă©rigĂ© Ă Barcelone en 1982. Ses fantasmagories, son style qui Ă©voque les st..
« A la rencontre de Ralf Marsault »
Issu dâune thĂšse dâethnologie (sous la direction de Jean Arlaud, Paris 7), RĂ©sistance Ă lâeffacement est un remarquable exemple de visual studies, croisant les champs de lâhistoire de lâart et de lâanthropologie. AncrĂ© sur un « terrain », lâĂ©tude des Wagenburgen (regroupements de vĂ©hicules habitĂ©s) de Berlin (Waldemar et East Side Gallery essentiellement), focalisĂ© sur une population (les Wagenburger : des punks et des travellers), Ă un moment historique (de la chute du Mur Ă 1996), lâouvrage..
High-force catch bonds between the <i>Staphylococcus aureus</i> surface protein SdrE and complement regulator factor H drive immune evasion
The invasive bacterial pathogen Staphylococcus aureus recruits the complement regulatory protein factor H (fH) to its surface to evade the human immune system. Here, we report the identification of an extremely high-force catch bond used by the S. aureus surface protein SdrE to efficiently capture fH under mechanical stress. We find that increasing the external force applied to the SdrE-fH complex prolongs the lifetime of the bond at an extraordinary high force, 1,400 pN, above which the bond lifetime decreases as an ordinary slip bond. This catch-bond behavior originates from a variation of the dock, lock and latch interaction, where the SdrE ligand binding domains undergo conformational changes under stress, enabling the formation of long-lived hydrogen bonds with fH. The binding mechanism dissected here represents a potential target for new therapeutics against multidrug-resistant S. aureus strains. © 2023, The Author(s)
Scratching the surface : bacterial cell envelopes at the nanoscale
The bacterial cell envelope is essential for viability, the environmental gatekeeper and first line of defense against external stresses. For most bacteria, the envelope biosynthesis is also the site of action of some of the most important groups of antibiotics. It is a complex, often multicomponent structure, able to withstand the internally generated turgor pressure. Thus, elucidating the architecture and dynamics of the cell envelope is important, to unravel not only the complexities of cell morphology and maintenance of integrity but also how interventions such as antibiotics lead to death. To address these questions requires the capacity to visualize the cell envelope in situ via high-spatial resolution approaches. In recent years, atomic force microscopy (AFM) has brought novel molecular insights into the assembly, dynamics, and functions of bacterial cell envelopes. The ultrafine resolution and physical sensitivity of the technique have revealed a wealth of ultrastructural features that are invisible to traditional optical microscopy techniques or imperceptible in their true physiological state by electron microscopy. Here, we discuss recent progress in our use of AFM imaging for understanding the architecture and dynamics of the bacterial envelope. We survey recent studies that demonstrate the power of the technique to observe isolated membranes and live cells at (sub)nanometer resolution and under physiological conditions and to track in vitro structural dynamics in response to growth or to drugs
Towards an indigenization of modernity
Duas iniciativas recentes nos museus da França podem ser vistas como modos de revisitar a ânova museologiaâ dos anos 1970. Em 2013, Catherine Grenier curou a nova mostra permanente das coleçÔes do MusĂ©e national dâart moderne (Centre Pompidou), intitulada ModernitĂ©s plurielles, na qual ela buscou articular as chamadas artes com A maiĂșsculo como as artes e a cultura populares. A segunda iniciativa Ă© a do MusĂ©e des Civilisations de l'Europe et de la MediterranĂ©e (MuCEM), em Marselha, que acaba de lançar um programa de exposiçÔes confrontando a arte contemporĂąnea com as artes ditas populares : a primeira, no ano passado, foi dedicada a Picasso ; a segunda, serĂĄ dedicada a Jean Dubuffet. Meu artigo discute a histĂłria do que podemos chamar de âindigenização da modernidadeâ nos museus franceses
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