Can pain be self-managed?:Pain change in vulnerable participants to a health education programme

Chronic pain exerts a significant impact on the quality of life, giving rise to both physical and psycho-social vulnerabilities. It not only leads to direct costs associated with treatments, but also results in indirect costs due to the reduced productivity of affected individuals. Chronic conditions can be improved by reducing modifiable risk factors. Various educational programs, including the Chronic Disease Self-Management Programme (CDSMP), have demonstrated the advantages of enhancing patient empowerment and health literacy. Nevertheless, their efficacy in addressing pain symptoms has received limited attention, especially concerning vulnerable populations. This research aims to assess the effectiveness of the CDSMP in alleviating pain among socio-economically vulnerable participants with chronic conditions. By accounting for a wide range of variables, and using data from the EFFICHRONIC project (EU health programme), we investigated the changes in pain levels after the intervention, among 1070 participants from five European countries. Our analyses revealed a significant reduction in pain following the intervention. This finding supports the notion that training programs can effectively ameliorate pain and alleviate its impact on the quality of life, particularly in vulnerable populations. Younger participants, as well as those with higher education levels and individuals experiencing higher levels of pain at baseline, were more likely to experience a reduction in their pain levels. These findings underscore the importance of recognising the social determinants of health. The study was registered at ClinicalTrials.gov (ISRCTN70517103).</p

Characterization of cell death induced by vinflunine, the most recent Vinca alkaloid in clinical development

Vinflunine, the most recent Vinca alkaloid in clinical development, demonstrated superior antitumour activity to other Vincas in preclinical tumour models. This study aimed to define its molecular mechanisms of cell killing in both parental sensitive and vinflunine-resistant P388 leukaemia cells. Vinflunine treatment of these cells resulted in apoptosis characterized by DNA fragmentation and proteolytic cleavage of poly-(ADP-ribose) polymerase. Apoptosis-inducing concentrations of vinflunine caused c-Jun N-terminal kinase 1 stimulation, as well as caspases-3/7 activation. This activation of caspases and the induction of apoptosis could be inhibited by the caspase inhibitor acetyl-Asp-Glu-Val-Asp-aldehyde. Interestingly, the apoptosis signal triggered by vinflunine in these P388 cells was not mediated through Bcl-2 phosphorylation. In addition, when vinflunine resistance was developed in P388 cells, it was associated with resistance to vinflunine-induced apoptosis, as reflected by a loss of capacity to induce DNA fragmentation and PARP degradation, and characterized by increased levels of Bcl-2 and Bfl-1/A1. Therefore, these data indirectly implicate Bcl-2 and Bfl-1/A1 in vinflunine-induced cell death mechanisms

Long-term outcomes of CLIPPERS (chronic lymphocytic inflammation with pontine perivascular enhancement responsive to steroids) in a consecutive series of 12 patients.

BACKGROUND: Chronic lymphocytic inflammation with pontine perivascular enhancement responsive to steroids (CLIPPERS) is a central nervous system inflammatory disease. OBJECTIVE: To describe the disease course of CLIPPERS. DESIGN: A nationwide study was implemented to collect clinical, magnetic resonance imaging, cerebrospinal fluid, and brain biopsy specimen characteristics of patients with CLIPPERS. SETTING: Academic research. PATIENTS: Twelve patients with CLIPPERS. MAIN OUTCOME MEASURES: The therapeutic management of CLIPPERS was evaluated. RESULTS: Among 12 patients, 42 relapses were analyzed. Relapses lasted a mean duration of 2.5 months, manifested frequent cerebellar ataxia and diplopia, and were associated with a mean Expanded Disability Status Scale (EDSS) score of 4. Besides typical findings of CLIPPERS, magnetic resonance imaging showed brainstem mass effect in 5 patients, extensive myelitis in 3 patients, and closed ring enhancement in 1 patient. Inconstant oligoclonal bands were found on cerebrospinal fluid investigation in 4 patients, with an increased T-cell ratio of CD4 to CD8. Among 7 available brain biopsy specimens, staining was positive for perivascular CD4 T lymphocytes in 5 samples. Thirty-eight of 42 relapses were treated with pulse corticosteroid therapy, which led to improvement, with a mean residual EDSS score of 1.9 (range, 0-7). In 1 patient with untreated relapses, scores on the EDSS progressively increased to a score of 10 at death. Among 5 patients without long-term corticosteroid therapy, the mean annualized relapse rate was 0.5 (range, 0.25-2.8). Among 7 patients taking oral corticosteroids, no relapses occurred in those whose daily dose was 20 mg or higher. No progressive course of CLIPPERS was observed. Four patients with a final EDSS score of 4 or higher had experienced previous severe relapses (EDSS score, ≥5) and brainstem and spinal cord atrophy. CONCLUSIONS: CLIPPERS is a relapsing-remitting disorder without progressive forms. Long-term disability is correlated with the severity of previous relapses. Further studies are needed to confirm that prolonged corticosteroid therapy prevents further relapses.journal article2012 Julimporte

Using the intergenerational solidarity framework to understand the grandparent–grandchild relationship: A scoping review

Intergenerational interactions and exchange are major components of grandparenting, and the present study sought to examine how the intergenerational solidarity framework has been used to investigate grandparenting practices across the lifespan and in different cultures. This framework is widely used across cultures and provides a basis to discuss the future of grandparenting research, considering cultural intermingling and changes in society. Following PRISMA-ScR guidelines, we searched three databases (PsycInfo, PubMed, Web of Science). Finally, 42 empirical studies that met the inclusion criteria were included in this scoping review. They were published between 1991 and 2020 and assessed intergenerational solidarity between grandparents and their grandchildren. Our findings show that research on grandparenting based on the intergenerational solidarity framework has increased in the last 30 years, and that this model provides a comprehensive approach to studying grandparenting across the lifespan in different cultures. The present study identified cross-cultural differences in the prevalence of the types of intergenerational solidarity. Affectual solidarity was shown to be the most studied dimension of intergenerational solidarity in North America, Europe and Israel while normative solidarity was the most represented in Asian studies. The only Australian study investigated affectual and functional solidarity. This model is thus suitable for studying grandparenting, but further studies are needed to investigate changes in intergenerational solidarity between grandparents and their grandchildren at different stages of development and account for cultural specificities

Intergenerational affectionate communication: conceptions of young adults toward their grandparent

International audienceTheoretical background Methods Results Discussion References Grandparent (GP)-Grandchild (GC) relationship is usually meaningful for both generations and of strong influence on each other lives. GP positively influence their GC's development and well-being (Mansson, 2015). Previous research underlined the influence of the frequency of contact, geographic distance, grandparent's age, grandparent's health as well as many other variables on GP-GC closeness. Notwithstanding, few studies have been conducted on the influence of communication, and specifically affectionate communication on GP-GC closeness. While creating the Grandchildren Received Affection Scale, Mansson (2013) found that GC received four types of affectionate communication from their GP: love and esteem, caring, memories and humor, and celebratory affection. Those four types of affectionate communication constitute the four dimensions of this scale. Mansson, Floyd, & Soliz (2017) found that received affection from GP is associated positively with GCs' perceptions of their GP and their GP-GC relationship as well as with GC's perceived shared family identity with their grandparent but not with celebratory affection and shared family identity A sample of young adults students between 18 and 25 years old (N= 285) completed the French Translation of the Grandchildren Received Affection Scale (GRAS) (Mansson, 2013) as well as demographics and four complementary scales: Ideal Grandparent Scale (Mansson, 2015), Parental Encouragement Scale (Soliz & Harwood, 2006), Shared Family Identity Scale (Soliz & Harwood, 2006), and the CES-D (Radloff, 1977) while thinking about the grandparent with the closest day of birth. The GRAS is composed of 17 items split in 4 dimensions (Love and esteem, caring, memories and humor, celebratory affection)

Considering Security and Quality of Service in SLS to improve Policy-based Mabagement of Multimedia services,” ICN-07

Abstract-This paper proposes to improve policy-based management by integrating security parameters into the Service Level Specification (SLS). Integrating those parameters in the QoS part of the Service Level Agreement (SLA) specification is of particular importance for multimedia services requiring security since QoS is negotiated when the multimedia service is deployed. Security mechanisms need to be negotiated at that time when sensible multimedia information is exchanged. In this paper we show that including security parameters in SLA specification improves the negotiation and deployment of security and QoS policies for multimedia services. The parameters this paper proposes to integrate have the advantage to be understandable by end-users and service providers

Psychologie sociale

Askevis-Leherpeux Françoise, Lemoine C., Lassarre D., Duflos A. Psychologie sociale. In: L'année psychologique. 1985 vol. 85, n°4. pp. 622-627

Psychologie sociale

Askevis-Leherpeux Françoise, Lemoine C., Lassarre D., Duflos A. Psychologie sociale. In: L'année psychologique. 1985 vol. 85, n°4. pp. 622-627